Doptelet Disease Interactions
There are 2 disease interactions with Doptelet (avatrombopag).
Avatrombopag (applies to Doptelet) severe renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
The effect of severe renal impairment (CrCl < 30 mL/min) including patients requiring hemodialysis on avatrombopag pharmacokinetics is unknown. Caution and monitoring is advised.
TPO receptor agonists (applies to Doptelet) thrombotic / thromboembolic complications
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: History - Thrombotic/Thromboembolic Disorder, Protein C Deficiency, Thrombotic/Thromboembolic Disorder
Thromboembolic complications may result from increases in platelet counts with TPO receptor agonists such as avatrombopag, lusutrombopag, and eltrombopag. Consider the potential for increased risk of thromboembolism when administering these medications to patients with known risk factors for thromboembolism, including genetic prothrombotic conditions (Factor V Leiden, Prothrombin 20210 A, Antithrombin deficiency or Protein C or S deficiency).
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Doptelet drug interactions
There are 88 drug interactions with Doptelet (avatrombopag).
Doptelet alcohol/food interactions
There is 1 alcohol/food interaction with Doptelet (avatrombopag).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
