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Atropine-Care Disease Interactions

There are 2 disease interactions with Atropine-Care (atropine ophthalmic).

Major

Anticholinergics (applies to Atropine-Care) glaucoma

Major Potential Hazard, Moderate plausibility. Applicable conditions: Glaucoma/Intraocular Hypertension

Anticholinergic agents are contraindicated in patients with primary glaucoma, a tendency toward glaucoma (narrow anterior chamber angle), or adhesions (synechiae) between the iris and lens, as well as for the elderly and others in whom undiagnosed glaucoma or excessive pressure in the eye may be present. Because anticholinergics cause mydriasis, they may exacerbate these conditions.

References

  1. Schuller DE, Turkewitz D (1986) "Adverse effects of antihistamines." Postgrad Med, 79, p. 75-86
  2. (2002) "Product Information. Dimetane (brompheniramine)." Wyeth-Ayerst Laboratories
  3. "Product Information. Chlor-Trimeton (chlorpheniramine)." Schering-Plough
  4. (2002) "Product Information. Thorazine (chlorpromazine)." SmithKline Beecham
  5. (2002) "Product Information. Periactin (cyproheptadine)." Merck & Co., Inc
  6. (2002) "Product Information. Benadryl (diphenhydramine)." Parke-Davis
  7. (2001) "Product Information. Phenergan (promethazine)." Wyeth-Ayerst Laboratories
  8. (2001) "Product Information. Tavist (clemastine)." Sandoz Pharmaceuticals Corporation
  9. (2001) "Product Information. Optimine (azatadine)." Schering Corporation
  10. O'Connor PS, Mumma JV (1985) "Atropine toxicity." Am J Ophthalmol, 99, p. 613-4
  11. Clearkin LG (1992) "Angle closure glaucoma precipitated by atropine." Arch Intern Med, 152, p. 880
  12. Berdy GJ, Berdy SS, Odin LS, Hirst LW (1991) "Angle closure glaucoma precipitated by aerosolized atropine." Arch Intern Med, 151, p. 1658-60
  13. Pecora JL (1979) "Malignant glaucoma worsened by miotics in a postoperative angle- closure glaucoma patient." Ann Ophthalmol, 11, p. 1412-4
  14. Holland MG (1974) "Autonomic drugs in ophthalmology: some problems and promises. Section II: Anticholinergic drugs." Ann Ophthalmol, 6, p. 661-4
  15. Kanto J (1983) "New aspects in the use of atropine." Int J Clin Pharmacol Ther Toxicol, 21, p. 92-4
  16. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
  17. (2001) "Product Information. Compazine (prochlorperazine)." SmithKline Beecham
  18. Goldstein JH (1971) "Effects of drugs on cornea, conjunctiva, and lids." Int Ophthalmol Clin, 11, p. 13-34
  19. (2001) "Product Information. Cogentin (benztropine)." Merck & Co., Inc
  20. (2001) "Product Information. Artane (trihexyphenidyl)." Lederle Laboratories
  21. (2001) "Product Information. Moban (molindone)." Gate Pharmaceuticals
  22. "Product Information. Orap (pimozide)." Gate Pharmaceuticals
  23. (2001) "Product Information. Poly-Histine-D (pyrilamine)." Bock Pharmacal Company
View all 23 references
Minor

Anticholinergics (applies to Atropine-Care) hypertension

Minor Potential Hazard, Moderate plausibility.

Cardiovascular effects of anticholinergics may exacerbate hypertension. Therapy with anticholinergic agents should be administered cautiously in patients with hypertension.

References

  1. (2002) "Product Information. Benadryl (diphenhydramine)." Parke-Davis
  2. (2001) "Product Information. Antivert (meclizine)." Roerig Division
  3. (2001) "Product Information. Marezine (cyclizine)." Glaxo Wellcome
  4. Valentin N, Staffeldt H, Kyst A (1984) "Effect of i.v. atropine on cardiac rhythm, heart rate, blood pressure and airway secretion during isoflurane anaesthesia." Acta Anaesthesiol Scand, 28, p. 621-4
  5. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
  6. (2001) "Product Information. Artane (trihexyphenidyl)." Lederle Laboratories
  7. (2002) "Product Information. Atropisol (atropine ophthalmic)." Ciba Vision Ophthalmics
View all 7 references

Atropine-Care drug interactions

There are 16 drug interactions with Atropine-Care (atropine ophthalmic).

Atropine-Care alcohol/food interactions

There is 1 alcohol/food interaction with Atropine-Care (atropine ophthalmic).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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