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Atropine use while Breastfeeding

Drugs containing Atropine: Lomotil, Donnatal, Antispasmodic, Lonox, AtroPen, Phenohytro, Atropine-Care, Elixiral, Isopto Atropine, Lomocot, Show all 59 »Spasmolin, DuoDote, Antispas, Motofen, Donnatal Extentabs, Atropisol, Hyosophen, Donnapine, Servira, Logen, Donnaphen, Stahist, Bellatal ER, Me-PB-Hyos, Quadrapax, Alkabel-SR, Spasquid, Bellalphen, D-Tal, Se-Donna PB HYOS, RE-PB Hyos Elixir, Antrocol, Sal-Tropine, ATNAA, Sta-D, PB-Hyos, Kinesed, B-Donna Tablets, Vitetal, Barbidonna, Bellatal, Bellahist-D LA, Ex-Tuss, Protuss Tablet, Enlon-Plus, Vi-Atro, AccuHist LA, Atrosulf-1, Lomanate, Rolatuss-SR, Deconhist LA, Histacol LA, Chardonna-2, Ocu-Tropine, Ru-Tuss, Respa-AR, Atreza, Atrohist Plus, Haponal

Atropine Levels and Effects while Breastfeeding

Summary of Use during Lactation

No information is available on the use of atropine during breastfeeding. Long-term use of atropine might reduce milk production or milk letdown, but a single systemic or ophthalmic dose is not likely to interfere with breastfeeding. During long-term use, observe for signs of decreased lactation (e.g., insatiety, poor weight gain).

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information in nursing mothers was not found as of the revision date. Anticholinergics can inhibit lactation in animals, apparently by inhibiting growth hormone and oxytocin secretion.[1][2][3][4][5] Anticholinergic drugs can also reduce serum prolactin in nonnursing women.[6] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

References

1. Aaron DK, Ely DG, Deweese WP et al. Reducing milk production in ewes at weaning using restricted feeding and methscopolamine bromide. J Anim Sci. 1997;75:1434-42. PMID: 9250502

2. Powell MR, Keisler DH. A potential strategy for decreasing milk production in the ewe at weaning using a growth hormone release blocker. J Anim Sci. 1995;73:1901-5. PMID: 7592071

3. Daniel JA, Thomas MG, Powell MR, Keisler DH. Methscopolamine bromide blocks hypothalmic-stimulated release of growth hormone in ewes. J Anim Sci. 1997;75:1359-62. PMID: 9159285

4. Bizzarro A, Iannucci F, Tolino A et al. Inhibiting effect of atropine on prolactin blood levels after stimulation with TRH. Clin Exp Obstet Gynecol. 1980;7:108-11. PMID: 6788407

5. Svennersten K, Nelson L, Juvnas-Moberg K. Atropinization decreases oxytocin secretion in dairy cows. Acta Physiol Scand. 1992;145:193-4. PMID: 1636447

6. Masala A, Alagna S, Devilla L et al. Muscarinic receptor blockade by pirenzepine: effect on prolactin secretion in man. J Endocrinol Invest. 1982;5:53-5. PMID: 6808052

Atropine Identification

Substance Name

Atropine

CAS Registry Number

51-55-8

Drug Class

Anti-Arrhythmia Agents

Bronchodilator

Mydriatics

Parasympatholytics

Muscarinic Antagonists

Administrative Information

LactMed Record Number

586

Last Revision Date

20150310

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