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Atropine Side Effects

Medically reviewed by Drugs.com. Last updated on Oct 20, 2024.

Applies to atropine: intramuscular solution.

Precautions

Your doctor will check your progress closely while you or your child are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects.

This medicine may cause heart problems. Check with your doctor right away if you or your child have chest pain or discomfort, dizziness, fainting, fast, slow, or irregular heartbeat, lightheadedness, or pounding or rapid pulse.

This medicine may make you sweat less, which can cause your body temperature to rise. Be careful when you exercise and during hot weather. You could overheat or get heat stroke. Check with your doctor right away if you or your child have dizziness, fast, shallow breathing, fast, weak heartbeat, headache, muscle cramps, pale, clammy skin, thirst, or extremely high fever or body temperature.

This medicine may cause eye problems, including acute glaucoma. Check with your doctor right away if you or your child have blindness, blurred vision, decreased vision, eye pain, headache, nausea or vomiting, or tearing. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

This medicine may cause urinary retention (trouble passing urine or not fully emptying the bladder). Check with your doctor right away if you or your child have decreased in urine volume, decreased in frequency of urination, difficulty in passing urine, or painful urination.

Check with your doctor right away if you or your child have constipation, nausea, vomiting, or stomach pain. These may be symptoms of a serious stomach or bowel problem (eg, blockage).

This medicine may cause lung or breathing problems. Tell your doctor right away if you have an increase or thickening of mucous from the lungs.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Check with your doctor right away if you or your child have cough, difficulty swallowing, dizziness, fast heartbeat, hives, itching, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, skin rash, tightness in the chest, trouble breathing, or unusual tiredness or weakness.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of atropine

Along with its needed effects, atropine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking atropine:

More common side effects

  • bigger, dilated, or enlarged pupils
  • blindness
  • blurred vision
  • chest pain, discomfort, or tightness
  • cough
  • decreased vision
  • decrease in urine volume
  • decrease in frequency of urination
  • difficulty in passing urine
  • difficulty swallowing
  • dizziness
  • eye pain
  • extremely high fever or body temperature
  • fainting
  • fast, shallow breathing
  • fast, slow, or irregular heartbeat
  • fast, weak heartbeat
  • headache
  • hives, itching, skin rash
  • increase in mucous from lungs
  • lightheadedness
  • muscle cramps
  • nausea or vomiting
  • pain at the injection site
  • painful urination
  • pale, clammy skin
  • pounding or rapid pulse
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • stomach pain
  • tearing
  • thirst
  • trouble breathing
  • unusual tiredness or weakness

Less common side effects

  • decreased awareness or responsiveness
  • dryness or soreness of the throat
  • excessive muscle tone
  • hoarseness
  • loss of memory
  • muscle stiffness, tension, or tightness
  • overactive reflexes
  • problems with memory
  • seizures
  • severe sleepiness
  • shakiness and unsteady walk
  • unsteadiness, trembling or other problems with muscle control or coordination
  • voice changes

Incidence not known

  • change in color vision
  • confusion
  • difficulty seeing at night
  • discouragement
  • dry eyes
  • dry mouth
  • feeling sad or empty
  • hallucinations
  • holding false beliefs that cannot be changed by fact
  • increased sensitivity of the eyes to sunlight
  • lack of appetite
  • loss of interest or pleasure
  • shakiness in the legs, arms, hands, or feet
  • trembling or shaking of the hands or feet
  • trouble concentrating
  • trouble sleeping
  • unusual excitement, nervousness, or restlessness

Other side effects of atropine

Some side effects of atropine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • bloating
  • constipation
  • diarrhea
  • impotence
  • loss of libido
  • small or red spots on the skin

For healthcare professionals

Applies to atropine: compounding powder, injectable solution, intramuscular solution, intravenous solution, oral tablet.

General adverse events

Although individual reactions vary greatly, systemic doses are likely to produce the following effects:

0.5 mg: Slight dryness of the nose and mouth, bradycardia

1 mg: Greater dryness of nose and mouth with thirst; slowing, then acceleration of the heart; slight mydriasis

2 mg: Very dry mouth, tachycardia with palpitations, mydriasis, slight blurring of near vision

5 mg: Increase in the above symptoms plus disturbance of speech, difficulty swallowing, headache, hot, dry skin, restlessness with asthenia

10 mg and over: Above symptoms to extreme degrees, plus ataxia, excitement, disorientation, hallucinations, delirium, and coma

65 mg: May be fatal[Ref]

Cardiovascular

Nervous system

Ocular

Gastrointestinal

Dermatologic

Psychiatric

Other

Genitourinary

Hypersensitivity

Respiratory

Metabolic

Musculoskeletal

Local

Hematologic

Renal

See also:

References

1. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics

2. (2016) "Product Information. Atropine Sulfate (atropine)." American Regent Laboratories Inc

3. (2003) "Product Information. AtroPen (atropine)." Meridian Medical Technologies Inc

4. Cerner Multum, Inc. "UK Summary of Product Characteristics."

5. Cerner Multum, Inc. "Australian Product Information."

Further information

Atropine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.