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Atropine / diphenoxylate Disease Interactions

There are 3 disease interactions with atropine / diphenoxylate:


Diphenoxylate (Includes Atropine/diphenoxylate) ↔ Pseudomembranous Enterocolitis

Severe Potential Hazard, High plausibility

Applies to: Infectious Diarrhea/Enterocolitis/Gastroenteritis, Pseudomembranous Colitis

Antiperistaltic agents, such as diphenoxylate may prolong and/or worsen diarrhea associated with organisms that penetrate the intestinal mucosa and pseudomembranous enterocolitis associated with broad-spectrum antibiotics or enterotoxin-producing bacteria. Antiperistaltic agents should not be used in these conditions.


Antimuscarinics (Includes Atropine/diphenoxylate) ↔ Coronary Artery Disease

Moderate Potential Hazard, Moderate plausibility

Applies to: Ischemic Heart Disease, Arrhythmias

Antimuscarinic agents block vagal inhibition of the SA nodal pacemaker. These agents should be administered cautiously in patients with tachycardia, congestive heart failure, or coronary artery disease. Premature ventricular depolarization or ventricular tachycardia or fibrillation associated with antimuscarinic drugs is rare.


  1. Lunde P "Ventricular fibrillation after intravenous atropine for treatment of sinus bradycardia." Acta Med Scand 199 (1976): 369-71
  2. "Product Information. Atropine Sulfate Injection, USP (atropine)." ESI Lederle Generics, Philadelphia, PA.
  3. Richman S "Adverse effect of atropine during myocardial infarction. Enchancement of ischemia following intravenously administered atropine." JAMA 228 (1974): 1414-6
View all 4 references

Diphenoxylate (Includes Atropine/diphenoxylate) ↔ Ulcerative Colitis

Moderate Potential Hazard, Moderate plausibility

Applies to: Ulcerative Colitis

The use of diphenoxylate in patients with ulcerative colitis may induce toxic megacolon. These patients should be carefully observed and diphenoxylate therapy should be discontinued promptly if abdominal distention occurs or if other untoward symptoms develop.

atropine / diphenoxylate drug Interactions

There are 719 drug interactions with atropine / diphenoxylate

atropine / diphenoxylate alcohol/food Interactions

There is 1 alcohol/food interaction with atropine / diphenoxylate

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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