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Anastrozole Disease Interactions

There are 4 disease interactions with anastrozole:

Moderate

Anastrozole (applies to anastrozole) cardiovascular

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Ischemic Heart Disease

In studies of women with preexisting ischemic heart disease, an increased incidence of ischemic cardiovascular events was observed with the use of anastrozole. Caution should be exercised when prescribing anastrozole to these patients.

Moderate

Anastrozole (applies to anastrozole) cholesterol

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Hyperlipidemia

During a clinical trial, more patients receiving anastrozole were reported to have elevated serum cholesterol compared to patients receiving tamoxifen (9% versus 3.5%, respectively). Caution should be taken when this agent is prescribed to these patients.

Moderate

Anastrozole (applies to anastrozole) hepatic dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Anastrozole is extensively metabolized by the liver. Analysis of the pharmacokinetic disposition of anastrozole in patients with hepatic cirrhosis indicates that dosage adjustments of anastrozole are not necessary in patients with mild to moderate hepatic impairment. Clinical monitoring for toxicity associated with anastrozole therapy is recommended. Therapy with anastrozole should be administered cautiously in patients with severe hepatic impairment.

References

  1. "Product Information. Arimidex (anastrozole)." Zeneca Pharmaceuticals, Wilmington, DE.
  2. Lonning PE, Geisler J, Dowsett M "Pharmacological and clinical profile of anastrozole." Breast Cancer Res Treat 49 (1998): s53-7
Moderate

Anastrozole (applies to anastrozole) osteoporosis

Moderate Potential Hazard, Moderate plausibility.

Results from the clinical trial bone substudy at 12 and 24 months demonstrated that patients receiving anastrozole had a mean decrease in both lumbar spine and total hip bone mineral density (BMD) compared to baseline. Caution should exercise when prescribing this agent to patients with a risk of fractures, such as the elderly and patients with osteoporosis. Consider bone mineral density monitoring in patients treated with anastrozole.

Anastrozole drug interactions

There are 18 drug interactions with anastrozole

Anastrozole alcohol/food interactions

There is 1 alcohol/food interaction with anastrozole

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.