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Anastrozole Disease Interactions

There are 4 disease interactions with anastrozole:

Moderate

Anastrozole (Includes Anastrozole) ↔ Cardiovascular

Moderate Potential Hazard, Moderate plausibility

Applies to: Ischemic Heart Disease

In studies of women with preexisting ischemic heart disease, an increased incidence of ischemic cardiovascular events was observed with the use of anastrozole. Caution should be exercised when prescribing anastrozole to these patients.

Moderate

Anastrozole (Includes Anastrozole) ↔ Cholesterol

Moderate Potential Hazard, Moderate plausibility

Applies to: Hyperlipidemia

During a clinical trial, more patients receiving anastrozole were reported to have elevated serum cholesterol compared to patients receiving tamoxifen (9% versus 3.5%, respectively). Caution should be taken when this agent is prescribed to these patients.

Moderate

Anastrozole (Includes Anastrozole) ↔ Hepatic Dysfunction

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

Anastrozole is extensively metabolized by the liver. Analysis of the pharmacokinetic disposition of anastrozole in patients with hepatic cirrhosis indicates that dosage adjustments of anastrozole are not necessary in patients with mild to moderate hepatic impairment. Clinical monitoring for toxicity associated with anastrozole therapy is recommended. Therapy with anastrozole should be administered cautiously in patients with severe hepatic impairment.

References

  1. "Product Information. Arimidex (anastrozole)." Zeneca Pharmaceuticals, Wilmington, DE.
  2. Lonning PE, Geisler J, Dowsett M "Pharmacological and clinical profile of anastrozole." Breast Cancer Res Treat 49 (1998): s53-7
Moderate

Anastrozole (Includes Anastrozole) ↔ Osteoporosis

Moderate Potential Hazard, Moderate plausibility

Applies to: Osteoporosis

Results from the a clinical trial bone substudy at 12 and 24 months demonstrated that patients receiving anastrozole had a mean decrease in both lumbar spine and total hip bone mineral density (BMD) compared to baseline. Caution should exercised when prescribing this agent to patients with a risk of fractures, such as the elderly and patients with osteoporosis. Consider bone mineral density monitoring in patients treated with anastrozole.

anastrozole drug Interactions

There are 41 drug interactions with anastrozole

anastrozole alcohol/food Interactions

There is 1 alcohol/food interaction with anastrozole

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2016 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

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