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Anastrozole Side Effects

Medically reviewed by Philip Thornton, DipPharm. Last updated on Apr 14, 2023.

Applies to anastrozole: oral tablet.

Serious side effects of Anastrozole

Along with its needed effects, anastrozole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking anastrozole:

More common

Less common

Incidence not known

Other side effects of Anastrozole

Some side effects of anastrozole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

Incidence not known

For Healthcare Professionals

Applies to anastrozole: compounding powder, oral tablet.

Cardiovascular

Cardiovascular side effects have included hypertension (up to 13%), edema (up to 11%), including peripheral edema (up to 9%). Ischemic cardiovascular disease (4%) has also been reported.[Ref]

Musculoskeletal

Very common (10% or more): Arthritis/arthralgia/arthrosis/joint disorder/joint pain/joint stiffness (36%), back pain (12%), bone pain (12%), osteoporosis (11%), fracture (10%)

Common (1% to 10%): Myalgia, anorexia

Uncommon (0.1% to 1%): Trigger finger[Ref]

Gastrointestinal

Very common (10% or more): Nausea (20%), vomiting (11%)

Common (1% to 10%): Abdominal pain, diarrhea, constipation, dyspepsia, gastrointestinal disorder, dry mouth[Ref]

Other

Very common (10% or more): Fatigue/asthenia (19%), pain (17%), accidental injury (10%), lymphedema (10%), peripheral edema (10%)

Common (1% to 10%): Infection, flu syndrome, cyst, fever, neck pain, malaise[Ref]

Psychiatric

Very common (10% or more): Mood disturbances (19%), depression, insomnia[Ref]

Nervous system

Very common (10% or more): Headache (18%), depression (13%), insomnia (10%)

Common (1% to 10%): Dizziness, anxiety, paresthesia, hypertonia, cerebrovascular event (cerebrovascular accident, cerebral ischemia, cerebral infarct), somnolence, confusion, nervousness, carpal tunnel syndrome, sensory disturbances (e.g., taste loss and taste perversion)[Ref]

Dermatologic

Very common (10% or more): Rash (11%)

Common (1% to 10%): Sweating, alopecia/hair thinning, pruritus

Rare (less than 0.1%): Skin reactions (lesions, ulcers blisters), erythema multiforme, cutaneous vasculitis (including Henoch-Schonlein purpura)

Very rare (less than 0.01%): Stevens-Johnson syndrome[Ref]

Respiratory

Very common (10% or more): Dyspnea (11%), increased cough (11%), pharyngitis (10%)

Common (1% to 10%): Sinusitis, bronchitis, rhinitis[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection, breast pain, vulvovaginitis, vaginal hemorrhage, vaginitis, vaginal discharge, vaginal bleeding, vaginal dryness, pelvic pain, leukorrhea[Ref]

Hematologic

Common (1% to 10%): Anemia, leukopenia[Ref]

Hepatic

Common (1% to 10%): Increased gamma GT, increased SGOT, increased SGPT, increased alkaline phosphatase

Uncommon (0.1% to 1%): Hepatobiliary events (e.g., increased bilirubin), hepatitis

Rare (less than 0.1%): Changes in liver function (liver inflammation, liver pain, liver swelling)[Ref]

Metabolic

Common (1% to 10%): Weight gain, hypercholesterolemia, weight loss, anorexia

Uncommon (0.1% to 1%): Hypercalcemia (with or without an increase in parathyroid hormone)[Ref]

Hypersensitivity

Common (1% to 10%): Allergic reactions

Uncommon (0.1% to 1%): Urticaria

Rare (less than 0.1%): Anaphylaxis, anaphylactoid reaction

Very rare (less than 0.01%): Angioedema[Ref]

Ocular

Common (1% to 10%): Cataracts[Ref]

Oncologic

Common (1% to 10%): Neoplasm, tumor flare

Uncommon (0.1% to 1%): Endometrial cancer[Ref]

Frequently asked questions

References

1. Product Information. Arimidex (anastrozole). Astra-Zeneca Pharmaceuticals. 2001;PROD.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.