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Anastrozole Dosage

Applies to the following strength(s): 1 mg

The information at is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Breast Cancer

Initial dose: 1 mg orally taken once a day
Duration of therapy: Until tumor progression (treatment of advanced breast cancer); unknown (adjuvant treatment of early breast cancer)

-Adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer;
-First-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer;
-Second-line treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy.

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Mild to Moderate Hepatic Impairment: No adjustment recommended.
Stable Hepatic Cirrhosis: No adjustment recommended.
Severe Hepatic Impairment: Data not available.


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available.

Other Comments

Administration Advice:
-This drug can be taken with or without food.

-No glucocorticoid or mineralocorticoid replacement therapy is necessary during treatment with this drug.
-There are no data to support the use of this drug with LHRH analogs.
-Overdosage: There is no specific antidote; dialysis may be helpful because this drug is not highly protein bound.

-Bone mineral density; serum cholesterol

Patient Advice:
-If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the next regularly scheduled dose. Do not take 2 doses at the same time.
-This drug may cause side effects such as drowsiness that can affect your ability to perform certain activities; avoid driving and other potentially dangerous activities until you know how this drug affects you.