Medically reviewed by Drugs.com. Last updated on Aug 19, 2020.
Applies to the following strengths: 1 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Breast Cancer
Initial dose: 1 mg orally taken once a day
Duration of therapy: Until tumor progression (treatment of advanced breast cancer); unknown (adjuvant treatment of early breast cancer)
-Adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer;
-First-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer;
-Second-line treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy.
Renal Dose Adjustments
No adjustment recommended.
Liver Dose Adjustments
Mild to Moderate Hepatic Impairment: No adjustment recommended.
Stable Hepatic Cirrhosis: No adjustment recommended.
Severe Hepatic Impairment: Data not available.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available.
-This drug can be taken with or without food.
-No glucocorticoid or mineralocorticoid replacement therapy is necessary during treatment with this drug.
-There are no data to support the use of this drug with LHRH analogs.
-Overdosage: There is no specific antidote; dialysis may be helpful because this drug is not highly protein bound.
-Bone mineral density; serum cholesterol
-If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the next regularly scheduled dose. Do not take 2 doses at the same time.
-This drug may cause side effects such as drowsiness that can affect your ability to perform certain activities; avoid driving and other potentially dangerous activities until you know how this drug affects you.
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