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Lithostat Disease Interactions

There are 3 disease interactions with Lithostat (acetohydroxamic acid).

Major

Acetohydroxamic acid (applies to Lithostat) renal dysfunction

Major Potential Hazard, High plausibility.

Acetohydroxamic acid is primarily eliminated by the kidney and it is contraindicated in patients whose renal function is poor (serum creatinine more than 2.5 mg/dl and/or creatinine clearance less than 20 mL/min). Patients with less marked renal impairment may be at increased risk of toxicity associated with administration of acetohydroxamic acid and therapy should be administered cautiously and reduced dosage may be necessary.

References

  1. "Product Information. Lithostat (acetohydroxamic acid)." Mission Pharmacal Company PROD (2001):
Moderate

Acetohydroxamic acid (applies to Lithostat) bone marrow depression

Moderate Potential Hazard, High plausibility. Applicable conditions: Bone Marrow Depression/Low Blood Counts, Bleeding, Fever

The use of acetohydroxamic acid is a known inhibitor of DNA synthesis and also chelates metals - notably iron. Its bone marrow suppressant effect is probably related to its ability to inhibit DNA synthesis, but anemia could also be related to depletion of iron stores. Clinical monitoring of the platelet and white cell count is recommended in patients with bone marrow depression.

References

  1. "Product Information. Lithostat (acetohydroxamic acid)." Mission Pharmacal Company PROD (2001):
Moderate

Acetohydroxamic acid (applies to Lithostat) hepatic function

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Abnormalities of liver function have not been reported to date. However, a chloro-benzene derivative of acetohydroxamic acid caused significant liver dysfunction in an unrelated study. Therefore, close monitoring of liver function is highly recommended in patients receiving AHA, especially in those with liver impairment.

References

  1. "Product Information. Lithostat (acetohydroxamic acid)." Mission Pharmacal Company PROD (2001):

Lithostat drug interactions

There are 8 drug interactions with Lithostat (acetohydroxamic acid).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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