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Tranexamic acid (Intravenous)

Generic name: tranexamic acid (tran-ex-AM-ik AS-id)
Drug class: Miscellaneous coagulation modifiers

Medically reviewed by Drugs.com. Last updated on Jan 23, 2021.

Commonly used brand name(s)

In the U.S.

  • Cyklokapron

Available Dosage Forms:

  • Solution

Therapeutic Class: Hemostatic

Uses for tranexamic acid

Tranexamic acid injection is used to control or prevent excessive or heavy bleeding during dental procedures in patients with hemophilia.

Tranexamic acid injection is an antifibrinolytic agent. It works by blocking the breakdown of blood clots. It may also be used for other conditions as determined by your doctor.

Tranexamic acid is to be given only by or under the direct supervision of your doctor.

Before using tranexamic acid

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For tranexamic acid, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to tranexamic acid or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of tranexamic acid injection in the pediatric population.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of tranexamic acid injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution for patients receiving tranexamic acid.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving tranexamic acid, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using tranexamic acid with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Desogestrel
  • Dienogest
  • Drospirenone
  • Estradiol
  • Ethinyl Estradiol
  • Ethynodiol
  • Etonogestrel
  • Gestodene
  • Levonorgestrel
  • Medroxyprogesterone
  • Mestranol
  • Nomegestrol
  • Norelgestromin
  • Norethindrone
  • Norgestimate
  • Norgestrel
  • Segesterone
  • Ulipristal

Using tranexamic acid with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Anti-Inhibitor Coagulant Complex
  • Chlorpromazine
  • Tretinoin

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of tranexamic acid. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood clots, active or
  • Subarachnoid hemorrhage (bleeding in the brain)—Should not be used in patients with these conditions.
  • Eye or vision problems or
  • Seizures, history of—Use with caution. May make these conditions worse.
  • Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper use of tranexamic acid

A nurse or other trained health professional will give you tranexamic acid in a medical facility. It is given through a needle placed into one of your veins. Tranexamic acid is for short-term use only, usually 2 to 8 days.

Precautions while using tranexamic acid

It is very important that your doctor check your or your child's progress closely while you are receiving tranexamic acid to make sure tranexamic acid is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects.

Tranexamic acid may increase your or your child's risk of developing blood clots. Check with your doctor right away if you or your child have swelling and pain in your arms, legs, or stomach, chest pain, trouble breathing, loss of sensation, confusion, or problems with muscle control or speech.

Receiving tranexamic acid together with birth control pills may also increase your risk of developing blood clots. Use another form of birth control (including condoms, spermicide) to keep from getting pregnant.

Tranexamic acid may increase your risk for seizures. This risk may more likely to occur if you are having a surgery for a heart or blood vessel problem. Talk to your doctor if you have any concerns.

Tranexamic acid may cause a serious allergic reaction, called anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing or swallowing, or any swelling of your hands, face, or mouth after receiving tranexamic acid.

If you or your child will be receiving tranexamic acid injection for longer than several days, your doctor may want you to have your eyes checked regularly by an ophthalmologist (eye doctor). Blurred vision, difficulty with reading, or any other change in vision may occur during or after treatment tranexamic acid.

Tranexamic acid may make you dizzy. Do not drive or do anything else that could be dangerous until you know how tranexamic acid affects you.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or non-prescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Tranexamic acid side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

  • Anxiety
  • bloody or cloudy urine
  • blurred or loss of vision
  • changes in vision
  • chest pain or tightness
  • confusion
  • cough
  • difficult or painful urination
  • difficulty swallowing
  • disturbed color perception
  • dizziness, fainting, or lightheadedness when getting up suddenly from a lying or sitting position
  • double vision
  • fast heartbeat
  • halos around lights
  • hives, itching, skin rash
  • migraine headache
  • night blindness
  • numbness of the hands
  • overbright appearance of lights
  • pain, redness, or swelling in the arm or leg
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • seizures
  • sudden decrease in the amount of urine
  • sweating
  • trouble breathing
  • tunnel vision
  • unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at injection site
  • diarrhea
  • giddiness
  • nausea
  • vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.