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Levamlodipine (Oral)

Commonly used brand name(s)

In the U.S.

  • Conjupri

Pharmacologic Class: Calcium Channel Blocker

Uses for levamlodipine

Levamlodipine is used alone or together with other medicines to lower hypertension (high blood pressure) in adults and children. High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure can reduce the risk of strokes and heart attacks.

Levamlodipine is a calcium channel blocker. It affects the movement of calcium into the cells of the heart and blood vessels. This relaxes the blood vessels and lowers blood pressure. A lower blood pressure will increase the supply of blood and oxygen to the heart.

Levamlodipine is available only with your doctor's prescription.

Before using levamlodipine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For levamlodipine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to levamlodipine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of levamlodipine to lower blood pressure in children younger than 6 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of levamlodipine in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving levamlodipine.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking levamlodipine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using levamlodipine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abametapir
  • Cyclosporine
  • Simvastatin
  • Tacrolimus

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of levamlodipine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Angina (chest pain) or
  • Heart attack, acute or
  • Heart or blood vessel disease (eg, coronary artery disease) or
  • Hypotension (low blood pressure)—Use with caution. May make these conditions worse.
  • Aortic stenosis (heart valve problem), severe or
  • Heart or blood vessel disease—Use with caution. May cause side effects to become worse.
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper use of levamlodipine

Take levamlodipine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

In addition to the use of levamlodipine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that levamlodipine will not cure your high blood pressure, but it does help control it. Therefore, you must continue to take it as directed if you expect to lower your blood pressure and keep it down. You might have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, strokes, or kidney disease.

You may take levamlodipine with or without food. Take it at the same time each day.

Dosing

The dose of levamlodipine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of levamlodipine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For high blood pressure:
      • Adults—At first, 2.5 milligrams (mg) once a day. Some patients may be started on 1.25 mg once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 5 mg per day.
      • Children 6 to 17 years of age—1.25 to 2.5 mg once a day.
      • Children younger than 6 years of age—Use and dose must be determined by your doctor.

Missed dose

If you miss a dose of levamlodipine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions while using levamlodipine

It is very important that your doctor check your or your child's progress at regular visits to make sure levamlodipine is working properly. Blood tests may be needed to check for unwanted effects.

Levamlodipine may cause angina (chest pain) or a heart attack in certain patients with severe heart or blood vessel disease. Check with your doctor right away if you are having chest pain or discomfort, fast or irregular heartbeat, nausea or vomiting, pain or discomfort in the arms, jaw, back, or neck, trouble breathing, or sweating.

Dizziness, lightheadedness, or fainting may also occur, especially when you get up suddenly from a lying or sitting position. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning. If you faint, call your doctor right away.

Dizziness, lightheadedness, or fainting may also occur if you exercise or if the weather is hot. Heavy sweating can cause loss of too much water and result in low blood pressure. Use extra care during exercise or hot weather.

Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

If you have been using levamlodipine regularly for several weeks, do not suddenly stop using it. Stopping suddenly may cause your chest pain or high blood pressure to come back or get worse. Check with your doctor for the best way to reduce gradually the amount you are taking before stopping completely.

Do not take other medicines unless they have been discussed with your doctor. This especially includes prescription or nonprescription (over-the-counter [OTC]) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and herbal or vitamin supplements.

Levamlodipine side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

  • Dizziness
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of warmth
  • redness of the face, neck, arms, and occasionally, upper chest

Rare

  • Chest pain
  • cough
  • difficulty with swallowing
  • dizziness
  • fainting
  • hives, itching, rash
  • increased sweating
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • slow heartbeat
  • tightness in the chest
  • trouble breathing
  • unusual tiredness or weakness

Incidence not known

  • Abdominal or stomach pain
  • clay-colored stools
  • dark urine
  • fever or chills
  • headache
  • loss of appetite
  • nausea
  • unpleasant breath odor
  • vomiting of blood yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Sleepiness or unusual drowsiness

Rare

  • Back pain
  • bleeding gums
  • bloated
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • burning, dry, or itching eyes
  • continuing ringing or buzzing or other unexplained noise in the ears
  • decreased sexual performance or desire
  • difficulty having a bowel movement (stool)
  • difficulty in moving
  • discharge, excessive tearing
  • double vision
  • dry mouth
  • excess air or gas in the stomach or intestines
  • eye pain
  • feeling of constant movement of self or surroundings
  • full feeling
  • hearing loss
  • irritation in the mouth
  • lack or loss of strength
  • muscle pain or stiffness
  • pain in the joints
  • passing gas
  • redness and swelling of the gums
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • redness, soreness, or itching skin
  • seeing double
  • sensation of spinning
  • shakiness in the legs, arms, hands, or feet
  • sores, welting, or blisters
  • trouble sleeping
  • vomiting
  • weight changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.