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Akynzeo (Intravenous)

Generic Name: fosnetupitant/palonosetron (fos-net-UE-pi-tant, pal-oh-NOE-se-tron)

Medically reviewed by Drugs.com. Last updated on May 30, 2020.

Commonly used brand name(s)

In the U.S.

  • Akynzeo

Available Dosage Forms:

  • Solution
  • Powder for Solution

Therapeutic Class: Antiemetic

Pharmacologic Class: Neurokinin-1 Receptor Antagonist

Uses for Akynzeo

Fosnetupitant and palonosetron combination injection is used together with dexamethasone to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy). Palonosetron and fosnetupitant work by blocking the signals to the brain that cause nausea and vomiting.

This medicine is to be given only by or under the direct supervision of your doctor.

Before using Akynzeo

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of fosnetupitant and palonosetron combination injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of fosnetupitant and palonosetron combination injection in the elderly. However, elderly patients are more likely to have kidney, liver, or heart problems, which may require caution in patients receiving fosnetupitant and palonosetron combination.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Apomorphine
  • Eliglustat

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abametapir
  • Acalabrutinib
  • Alfentanil
  • Alfuzosin
  • Almotriptan
  • Alprazolam
  • Amineptine
  • Amiodarone
  • Amitriptyline
  • Amitriptylinoxide
  • Amlodipine
  • Amoxapine
  • Amphetamine
  • Aprepitant
  • Aripiprazole
  • Atorvastatin
  • Avanafil
  • Avapritinib
  • Axitinib
  • Benzhydrocodone
  • Benzphetamine
  • Bosutinib
  • Brigatinib
  • Bromocriptine
  • Brompheniramine
  • Budesonide
  • Buprenorphine
  • Buspirone
  • Butorphanol
  • Cabozantinib
  • Carbamazepine
  • Chlorpheniramine
  • Cilostazol
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Clozapine
  • Cobicistat
  • Cobimetinib
  • Cocaine
  • Codeine
  • Colchicine
  • Conivaptan
  • Copanlisib
  • Crizotinib
  • Cyclobenzaprine
  • Cyclosporine
  • Dabrafenib
  • Daclatasvir
  • Darifenacin
  • Darunavir
  • Dasatinib
  • Desipramine
  • Desvenlafaxine
  • Dextroamphetamine
  • Dextromethorphan
  • Diazepam
  • Dibenzepin
  • Dihydrocodeine
  • Dihydroergotamine
  • Diltiazem
  • Docetaxel
  • Dofetilide
  • Domperidone
  • Doxepin
  • Dronedarone
  • Duloxetine
  • Efavirenz
  • Elbasvir
  • Eletriptan
  • Elexacaftor
  • Encorafenib
  • Entrectinib
  • Enzalutamide
  • Eplerenone
  • Ergotamine
  • Erythromycin
  • Escitalopram
  • Estradiol
  • Eszopiclone
  • Everolimus
  • Felodipine
  • Fenfluramine
  • Fentanyl
  • Flibanserin
  • Fluoxetine
  • Fluticasone
  • Fluvoxamine
  • Fosaprepitant
  • Fosphenytoin
  • Frovatriptan
  • Furazolidone
  • Grazoprevir
  • Guanfacine
  • Haloperidol
  • Hydrocodone
  • Hydrocortisone
  • Hydromorphone
  • Hydroxytryptophan
  • Ibrutinib
  • Imatinib
  • Imipramine
  • Indinavir
  • Iproniazid
  • Irinotecan
  • Irinotecan Liposome
  • Isocarboxazid
  • Itraconazole
  • Ivabradine
  • Ivacaftor
  • Ivosidenib
  • Lapatinib
  • Lasmiditan
  • Lemborexant
  • Lercanidipine
  • Levomilnacipran
  • Levorphanol
  • Linezolid
  • Lisdexamfetamine
  • Lithium
  • Lofepramine
  • Lomitapide
  • Lorcaserin
  • Lovastatin
  • Lumacaftor
  • Lumateperone
  • Lurasidone
  • Lurbinectedin
  • Maraviroc
  • Melitracen
  • Meperidine
  • Metaxalone
  • Methadone
  • Methamphetamine
  • Methylene Blue
  • Midazolam
  • Milnacipran
  • Mirtazapine
  • Mitotane
  • Moclobemide
  • Morphine
  • Morphine Sulfate Liposome
  • Nalbuphine
  • Naloxegol
  • Naratriptan
  • Nateglinide
  • Nefazodone
  • Nelfinavir
  • Neratinib
  • Nialamide
  • Nifedipine
  • Nilotinib
  • Nisoldipine
  • Nortriptyline
  • Omeprazole
  • Ondansetron
  • Opipramol
  • Oxycodone
  • Oxymorphone
  • Paclitaxel
  • Paritaprevir
  • Paroxetine
  • Pemigatinib
  • Pentazocine
  • Pexidartinib
  • Phenelzine
  • Phenytoin
  • Pimavanserin
  • Pimozide
  • Piperaquine
  • Procarbazine
  • Progesterone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Ranolazine
  • Rasagiline
  • Reboxetine
  • Remifentanil
  • Repaglinide
  • Rifabutin
  • Rifampin
  • Rimegepant
  • Rizatriptan
  • Rolapitant
  • Salmeterol
  • Saquinavir
  • Saxagliptin
  • Selegiline
  • Selpercatinib
  • Selumetinib
  • Sertraline
  • Sibutramine
  • Sildenafil
  • Simeprevir
  • Simvastatin
  • Sirolimus
  • Sonidegib
  • St John's Wort
  • Sufentanil
  • Sumatriptan
  • Sunitinib
  • Suvorexant
  • Tacrolimus
  • Tamoxifen
  • Tapentadol
  • Tazemetostat
  • Telithromycin
  • Temsirolimus
  • Tezacaftor
  • Thiotepa
  • Tianeptine
  • Ticagrelor
  • Tipranavir
  • Tolvaptan
  • Trabectedin
  • Tramadol
  • Tranylcypromine
  • Trazodone
  • Triazolam
  • Trimipramine
  • Tryptophan
  • Ubrogepant
  • Vardenafil
  • Venetoclax
  • Venlafaxine
  • Verapamil
  • Vilazodone
  • Vinblastine
  • Vincristine
  • Vinorelbine
  • Vorapaxar
  • Vortioxetine
  • Warfarin
  • Zaleplon
  • Zanubrutinib
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Dexamethasone

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Kidney disease, severe or
  • Liver disease, severe—Use is not recommended. Safety and efficacy have not been established in patients with these conditions.

Proper use of Akynzeo

A nurse or other trained health professional will give you this medicine in a medical facility. It is given through a needle placed into one of your veins. It must be given slowly, so the needle will have to remain in place for at least 30 minutes, about 30 minutes before starting your cancer treatment.

This medicine should come with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Precautions while using Akynzeo

It is very important that your doctor check your progress closely while you are receiving this medicine to make sure that it is working properly and to check for unwanted effects.

This medicine may cause a serious allergic reaction, called anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.

Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of a serious condition called serotonin syndrome. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Akynzeo side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

  • Agitation
  • confusion
  • cough or hoarseness
  • dizziness
  • fast heartbeat
  • fever
  • hearing or seeing things that are not there
  • hives, itching, skin rash
  • irritation
  • joint pain, stiffness or swelling
  • muscle twitching
  • overactive reflexes
  • poor coordination
  • redness of the skin
  • shivering
  • sweating
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • trembling or shaking
  • trouble breathing or swallowing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Headache
  • unusual tiredness or weakness

Less common

  • Constipation
  • heartburn
  • indigestion
  • stomach discomfort, upset, or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.