Comparing Tacrolimus vs Methotrexate
Tacrolimus | Methotrexate |
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Tacrolimus | Methotrexate |
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Prescription only
Prescribed for Nephrotic Syndrome, Organ Transplant - Rejection Reversal, Organ Transplant - Rejection Prophylaxis, Graft-versus-host disease, Crohn's Disease. tacrolimus may also be used for... View more |
Prescription only
Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
Related suggestions Graft-versus-host disease
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More about Tacrolimus | More about Methotrexate | ||||||||||||||||
Ratings & Reviews | |||||||||||||||||
Tacrolimus has an average rating of 8.1 out of 10 from a total of 48 ratings on Drugs.com. 76% of reviewers reported a positive effect, while 10% reported a negative effect. |
Methotrexate has an average rating of 6.6 out of 10 from a total of 334 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 23% reported a negative effect. |
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Drug Class | |||||||||||||||||
Side Effects | |||||||||||||||||
See also: tacrolimus side effects in more detail. |
See also: methotrexate side effects in more detail. |
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Generic Availability | |||||||||||||||||
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all tacrolimus prices |
View all methotrexate prices |
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Dosage Forms Available | |||||||||||||||||
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Brand Names | |||||||||||||||||
Astagraf XL, Envarsus XR, Prograf | Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep | ||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
21.2 hours |
15 hours |
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CSA Schedule ** View glossary of terms | |||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||||||||||
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||||||||||
A total of 832 drugs are known to interact with tacrolimus:
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A total of 694 drugs are known to interact with methotrexate:
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Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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Disease Interactions | |||||||||||||||||
First Approval Date | |||||||||||||||||
April 08, 1994 |
December 07, 1953 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
N/A |
N/A |
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More Information | |||||||||||||||||
Patient resources | |||||||||||||||||
Professional Resources | |||||||||||||||||
Related Treatment Guide | |||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.