Comparing Nextstellis vs Yaz

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Nextstellis (drospirenone / estetrol)	Yaz (drospirenone / ethinyl estradiol)	Enter another drug to compare

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Nextstellis (drospirenone / estetrol)	Yaz (drospirenone / ethinyl estradiol)	Enter another drug to compare
Prescription only Prescribed for Birth Control. Nextstellis may also be used for purposes not listed in this medication guide.	Prescription only Prescribed for Premenstrual Dysphoric Disorder, Acne, Birth Control. Yaz may also be used for purposes not listed in this medication guide.	Related suggestions Birth Control Mirena Nexplanon Lo Loestrin Fe NuvaRing Depo Provera Sprintec
More about Nextstellis (drospirenone / estetrol)	More about Yaz (drospirenone / ethinyl estradiol)
Ratings & Reviews
Nextstellis has an average rating of 6.9 out of 10 from a total of 28 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 14% reported a negative effect.	Yaz has an average rating of 5.9 out of 10 from a total of 999 ratings on Drugs.com. 45% of reviewers reported a positive effect, while 32% reported a negative effect.
View all 28 reviews	View all 999 reviews
Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.
View all Nextstellis side effects	Acne (23.6%) Depression (20.8%) Mood swings (20.4%) Anxiety (15.2%) Weight gain (13.7%) Cramps (10.9%) Headaches (9.1%) View all Yaz side effects
Drug Class
Contraceptives	Contraceptives
Generic Availability
No lower cost generic approved	Lower cost generic approved
Pricing and Coupons * Prices are without insurance
We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.
Get free Discount Card	Get free Discount Card

Dosage Forms
Oral tablet	Oral tablet
Brand Names
N/A	Other drospirenone / ethinyl estradiol brands include: Gianvi, Jasmiel, Lo-Zumandimine, Loryna, Melamisa, Nikki, Ocella, Syeda, Yaela, Yasmin, Zarah, Zumandimine View more
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.
32.5 hours (empirically)	32.5 hours
CSA Schedule ¹ View glossary of CSA terms
N Not a controlled drug Is not subject to the Controlled Substances Act.	N Not a controlled drug Is not subject to the Controlled Substances Act.
Pregnancy Category
Summary unavailable. See the full pregnancy warnings document.	X Category X Not for use in pregnancy See the full pregnancy warnings document.
Drug Interactions
A total of 525 drugs are known to interact with Nextstellis: 90 major drug interactions (228 brand and generic names) 412 moderate drug interactions (1677 brand and generic names) 23 minor drug interactions (144 brand and generic names)	A total of 593 drugs are known to interact with Yaz: 93 major drug interactions (234 brand and generic names) 455 moderate drug interactions (1852 brand and generic names) 45 minor drug interactions (515 brand and generic names)
Alcohol/Food/Lifestyle Interactions
Grapefruit juice may increase the blood levels of certain medications such as drospirenone. You... View more	Grapefruit juice may increase the blood levels of certain medications such as drospirenone. You... View more
Disease Interactions
Smoking Hyperkalemia Abnormal vaginal bleeding Carcinomas (estrogenic) Hypertension Thromboembolism/cardiovascular Hepatic neoplasms Obesity Angioedema Gallbladder disease Hyperlipidemia Liver disease Melasma Depression Glucose intolerance Retinal thrombosis Thyroid function tests	Smoking Hyperkalemia Abnormal vaginal bleeding Carcinomas (estrogenic) Hypercalcemia in breast cancer Hypertension Thromboembolism/cardiovascular Hepatic neoplasms Angioedema Gallbladder disease Hypercalcemia Hyperlipidemia Liver disease Melasma Depression Fluid retention Glucose intolerance Retinal thrombosis Thyroid function tests
First Approval Date
April 15, 2021	March 16, 2006
WADA Class View classifications
N/A	N/A
More Information
Side effects Drug interactions Dosage Pregnancy warnings Drug images	Side effects Drug interactions Dosage Pregnancy warnings Drug images Support group
Patient Resources
Nextstellis uses	Yaz uses
Professional Resources
Prescribing information	Prescribing information
Related Treatment Guide
Birth Control	Premenstrual Dysphoric Disorder Acne Birth Control

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

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Medical Disclaimer

Comparing Nextstellis vs Yaz

See also:

Provera

Depo Provera

Botox

Nexplanon

Slynd

Yaz

Mirena

Sprintec

Lo Loestrin Fe

Levonorgestrel

Further information

Comparing Nextstellis vs Yaz

See also:

Further information

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