Comparing Aleve-D Sinus & Cold vs Sudafed 12-Hour

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Aleve-D Sinus & Cold (naproxen / pseudoephedrine)	Sudafed 12-Hour (pseudoephedrine)	Enter another drug to compare

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Aleve-D Sinus & Cold (naproxen / pseudoephedrine)	Sudafed 12-Hour (pseudoephedrine)	Enter another drug to compare
Over-the-counter Prescribed for Sinus Symptoms, Nasal Congestion, Pain/Fever. Aleve-D Sinus & Cold may also be used for purposes not listed in this medication guide.	Prescription and OTC Prescribed for Nasal Congestion. Sudafed 12-Hour may also be used for purposes not listed in this medication guide.	Related suggestions Nasal Congestion Pseudoephedrine Phenylephrine Sudafed Congestion Afrin Oxymetazoline nasal Claritin-D
More about Aleve-D Sinus & Cold (naproxen / pseudoephedrine)	More about Sudafed 12-Hour (pseudoephedrine)
Ratings & Reviews
Aleve-D Sinus & Cold has an average rating of 9.7 out of 10 from a total of 3 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect.	Sudafed 12-Hour has an average rating of 5.8 out of 10 from a total of 6 ratings on Drugs.com. 50% of reviewers reported a positive effect, while 33% reported a negative effect.
View all 3 reviews	View all 6 reviews
Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.
View all Aleve-D Sinus & Cold side effects	View all Sudafed 12-Hour side effects
Drug Class
Upper respiratory combinations	Decongestants
Generic Availability
N/A	N/A
Pricing and Coupons * Prices are without insurance
We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.
Get free Discount Card	Get free Discount Card

Dosage Forms
Oral tablet, extended release	Oral tablet, extended release
Brand Names
Other naproxen / pseudoephedrine brands include: Aleve-D Sinus & Headache, Sinus & Cold D, Sudafed 12 Hour Pressure+Pain	Other pseudoephedrine brands include: 12 Hour Decongestant, 12 Hour Nasal Decongestant, Afrinol, Allermed, Cenafed, Children's Dimetapp Decongestant Infant, Chlor-Trimeton Nasal Decongestant, Contac Cold, Decofed, Decofed Liquid, Drixoral Decongestant Non-Drowsy, Efidac, Elixsure Decongestant, Entex, Genaphed, nasofed, Nexafed Nasal Decongestant, Novafed, Silfedrine, Sudafed 24-Hour, Sudafed Congestion, SudoGest, SudoGest 12 Hour, Suphedrin, Suphedrine, Zephrex-D View more
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.
18 hours	16 hours
CSA Schedule ¹ View glossary of CSA terms
N Not a controlled drug Is not subject to the Controlled Substances Act.	N Not a controlled drug Is not subject to the Controlled Substances Act.
Pregnancy Category
N Category N Not classified See the full pregnancy warnings document.	N Category N Not classified See the full pregnancy warnings document.
Drug Interactions
A total of 626 drugs are known to interact with Aleve-D Sinus & Cold: 116 major drug interactions (501 brand and generic names) 488 moderate drug interactions (1989 brand and generic names) 22 minor drug interactions (168 brand and generic names)	A total of 220 drugs are known to interact with Sudafed 12-Hour: 21 major drug interactions (91 brand and generic names) 193 moderate drug interactions (781 brand and generic names) 6 minor drug interactions (46 brand and generic names)
Alcohol/Food/Lifestyle Interactions
Ask your doctor before using naproxen together with alcohol. Do not drink alcohol while taking... View more	No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease Interactions
Asthma Fluid retention GI toxicity Rash Renal toxicities Thrombosis Cardiovascular disease Sodium Anemia Hepatotoxicity Hyperkalemia Platelet aggregation inhibition GI narrowing PKU BPH Diabetes Glaucoma	Cardiovascular disease GI narrowing PKU BPH Diabetes Glaucoma
First Approval Date
November 29, 1999	October 31, 1991
WADA Class View classifications
S6 - Stimulants	S6 - Stimulants
More Information
Side effects Drug interactions Dosage Pregnancy warnings Drug images	Side effects Drug interactions Dosage Pregnancy warnings Breastfeeding warnings Drug images
Patient Resources
Aleve-D Sinus & Cold uses	Sudafed 12-Hour uses
Professional Resources
N/A	N/A
Related Treatment Guide
Sinus Symptoms Nasal Congestion Pain/Fever	Nasal Congestion

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Aleve-D Sinus & Cold vs Sudafed 12-Hour

See also:

Advil

Aleve

Tepezza

Afrin

Naprosyn

Excedrin

IBU

Sudafed Congestion

Ecotrin

Excedrin Migraine

Further information

Comparing Aleve-D Sinus & Cold vs Sudafed 12-Hour

See also:

Further information

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