Comparing Adapalene Topical vs Isotretinoin
| Adapalene topical | Isotretinoin |
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| Adapalene topical | Isotretinoin |
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Prescription and OTC
Prescribed for Acne. Adapalene topical may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Rosacea, Acne, Granuloma Annulare, Acute Nonlymphocytic Leukemia, Pityriasis rubra pilaris, Melanoma - Metastatic. Isotretinoin may also be used for purposes not listed in this medication guide. View more |
Related suggestions |
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| More about Adapalene topical | More about Isotretinoin | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Adapalene topical has an average rating of 6.3 out of 10 from a total of 516 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 32% reported a negative effect. |
Isotretinoin has an average rating of 7.9 out of 10 from a total of 1060 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 13% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Adapalene topical side effects |
View all Isotretinoin side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Adapalene topical prices |
View all Isotretinoin prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Differin, Plixda | Absorica, Absorica LD, Accutane, Amnesteem, Claravis, Myorisan, Sotret, Zenatane | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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51 hours |
32 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 12 drugs are known to interact with Adapalene topical:
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A total of 141 drugs are known to interact with Isotretinoin:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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May 31, 1996 |
May 07, 1982 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.