Skip to Content

User Reviews for Sofosbuvir/velpatasvir

Also known as: Epclusa

Condition Avg. Rating Reviews Compare
Hepatitis C  
8.0
288 reviews 25 medications

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Sofosbuvir/velpatasvir

Grant Casteel · Taken for 1 to 6 months June 14, 2021

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “Wanted to take this time and let everyone know about my experience. I started taking my Epclusa March 22, 2021. Just finished my last dose tonight June 13. I did not miss a day of work and worked out five days a week during the entire treatment. I have been virus free since my first test at week four and have continued virus free throughout. Will have my SVR test sometime in September. For those of you that are concerned about starting treatment,I found it to be a breeze and I am sure you will too! Thankful for this treatment as I am at stage 2/3 fibrosis and hopefully I will regress to a lower stage if not completely.Good luck to everyone getting ready to start you much God bless!”

10 / 10
Was this helpful?YesNo
Jasonfarley091086 · Taken for 1 to 6 months June 8, 2021

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “I've been using Epclusa and I take one every night after dinner. I haven't experienced any side effects. I was scared at first because of the reviews I had read before starting ,but I'm glad I did. I haven't felt any changes . Might as well be a one a day vitamin because I fell great no side effects and viral load steady decreased. Once I'm completely done and cure I will write another review. Thanks Epclusa and doctors who made it possible for me to get this under control.”

10 / 10
Was this helpful?YesNo
Ejrichar369 · Taken for 1 to 6 months June 6, 2021

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “I am 9 months post treatment. The treatment itself was pretty easy. I discovered early on you have to drink a lot of water to prevent headaches. My main complaint is no one warned me about weight gain. I'm up over 20 lbs. Please be advised substantial weight post cure is not only possible its very common. When the virus gets cleared from your body your appetite comes back and you are able to eat full meals again. I wish someone would have warned me about that so I could have been more prepared. Still would have obviously done the treatment but it would have been nice to have been warned by my doctor.”

10 / 10
Was this helpful?YesNo

Frequently asked questions

Stormy · Taken for 1 to 6 months January 19, 2021

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “I have 5 days left of Epclusa. The first two months I experienced some headaches and tiredness. This 3rd month is really taking a toll on me though. The headaches are worse and I have no energy. I’ve felt too weak to even go to work for the past week. The worst part is I feel like I’m losing my mind. I don’t know if it’s depression or anxiety or what, but it’s definitely it very difficult to function in a normal, healthy way.”

7 / 10
Was this helpful?YesNo
AW · Taken for 1 to 6 months April 11, 2021

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “Think about it people! How many of you received this medicine free or better yet my company insurance paid 80 percent of $72,000.00. Guess where the other came from, a coupon that Epclusa provided. Ever heard of that before? It's been 15 months since I finished my last pill. My stomach looks as if I have cirrhosis, it feels like I have an infection in my stomach, I'm like the other lady states about hormonal issues I'm 65 and started having acne, I'm extremely depressed, I've developed major arthritic symptoms, this drug has cured the hep C but my day to day journey is horrific. I do not recommend this drug. Your doctor will tell you there are no side effects. How do they really know. I'll never listen to any doctor again. When any medication has only been around for a short period, don't label it as no side effects. Hope you doctor's and drug manufacturers can sleep good at night because you won't!”

1 / 10
Was this helpful?YesNo
Sheldoor February 12, 2021

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “Started Epclusa 2019 March for Hep C type 2b. I ate small items/meals throughout the day. Stayed hydrated + no caffeine of any sort. Took pill at 6 am with a piece of bread... was on extreme health regime while taking it. Nothing terrible. But after treatment was over, caffeine of any sort gives me a 3 day migraine. I am more sensitive to all chemicals in food and drink + get headaches easily, including fructose and sugar (small amounts)... by the way, I only got headaches before Epclusa when trying to get off coffee due to caffeine withdrawal. My adrenals and emotions seem to go from 1 to 10 very quickly. Although I am happy that Epclusa cured my hep C, it also has changed my life a lot. It is now Jan 2021, and I still experience these symptoms. I am very afraid to get the Covid-19 vaccination due to the headache side effect. Afraid my head may EXPLODE. hope this helps somebody...”

Was this helpful?YesNo
Jackie456 · Taken for 1 to 6 months March 25, 2021

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “I would not recommend this drug at all, I was fine before I took it, its been 2 years and I am getting worse. First got a rash on my head, when I started taking it, yeast infections for months, 5 months later the rash started on my feet, they were on fire, now the rash is all over my legs, looks like I was beat up, the side effects are not worth it at all, I don't trust doctors and this drug needs to be stopped! I know what big pharma are all about, money, After researching I am hoping I get to use better medicine to reverse the damage done!”

1 / 10
Was this helpful?YesNo

More FAQ

Rodney · Taken for 1 to 6 months October 30, 2019

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “I just want people to know that when the Epclusa is killing the hep c virus in your body your probably going to feel a little nausea. The virus is multiplying millions of times in your body - there's war between the epclusa and the hep c just hang in there you'll be glad when the 12 weeks are over god bless”

10 / 10
Was this helpful?YesNo
Andy · Taken for 1 to 6 months August 16, 2020

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “I was diagnosed Hep C 1 , and prescribed Epculsa, from the very first tablet I felt something working inside , within one month my count was down from millions to low numbers, the course was completed , I am now Hep C free. No side effects what so ever , thank you Gilliad & The NHS....!!!!!”

10 / 10
Was this helpful?YesNo
Grandpa DD · Taken for 1 to 6 months November 9, 2020

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “I was a Intravenous drug user from age 19 to 32 years old. Clean from all drugs from February 1 1988 to present. I have had hepatitis from age 19 to 65 years old and 6 weeks on epclusa with non detectable test I had hep C geno type 1A. So grateful for Epclusa. It has allowed me to live longer than expected and 6 more weeks until treatment is completed. Very mild side affects ( headache, mood swings and lite depression) so far. At the age of 45 to 50 I did interferon/ribavarin 3 separate times and never was able to finish due to terrible side affects. EPCLUSA will and is going to save my life. Thanks to everyone that made this happen.”

9 / 10
Was this helpful?YesNo
JeffM · Taken for 1 to 6 months April 23, 2021

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “I just finished my 12th and final week of taking Epclusa one week ago. I probably got Hep C in the Army during the early 1970's. I am now 68 years old. These are the side effects that I noticed - Brain Fog. Just not able to think clearly and rationally. Insomnia. I had to get medication to sleep. My normal libido was gone soon after starting Epclusa. I have had no sex with my wife or even the slightest desire to have sex. I will not know if the Epclusa got rid of the Hep C for another 3 weeks when I have the first Blood Test. Currently I am just wondering if I will ever feel normal again. I still feel like I am on the Epclusa. Talking to my doctor is a waste of time. She does not believe that Epclusa caused any of the problems that I am having.”

5 / 10
Was this helpful?YesNo
Blange 20 · Taken for 1 to 6 months September 6, 2019

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “Well on my first review 2019-07-28 I said I'd come back after a bit. Now I am just over half way through my treatment. I get what you all say about tinnitus. Also when I wake up in morning I'm the same with feeling rough. But once I've had a coffee it dies down. My feet have been aching a bit as has my back, but I've had no sickness or headaches. I think that if you have a life threatening disease like hep c which is never going away then it's like carrying bad luggage around everyday. If you get a chance to get rid of it and there is a few side effects that are quite manageable then it's got to be worth it. I felt ok apart from brain fog at first, but it's got a bit worse as I've gone on with meds. But I am more than willing to suffer these for 12wks than stay sick forever. I hope you all have as best time on epclusa that you all can and become hep c free. Take care people”

8 / 10
Was this helpful?YesNo
Ash · Taken for 1 to 6 months February 11, 2020

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “I gave blood and found out I was Hep C positive! Been on Epclusa for 2 months and didn’t have any side effects until month 2 when I started itching all over and noticed some random big bruises on my legs! Call doc and they ran test and found my test for hep c is negative all thanks to this medicine! Only one more month! Stay strong y’all!!!!”

10 / 10
Was this helpful?YesNo
Rodney · Taken for 1 to 6 months December 20, 2019

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “My name is Rodney I live in southeast Missouri I'm beginning my 3rd month on Epclusa just went in to get my blood results my Hep c. Virus is gone still got one more month of treatment I've had zero side effects this medicine is a life saver”

10 / 10
Was this helpful?YesNo
Moni · Taken for 1 to 6 months April 11, 2021

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “Just started my third month of Epclusa. So far not much of side effects. A little anxiety or irritation at times. No nausea, diarrhea, or anything like that so far. My doctor won’t test until a few weeks after final dose is taken. I did notice after the first four weeks I have much more energy and not feeling so depressed anymore. I will update again once I’ve finished taking the medication and after I’ve been tested again for viral detection.”

9 / 10
Was this helpful?YesNo
Anonymous · Taken for 1 to 6 months June 18, 2019

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “The first 3 weeks of using Epclusa was insane...I was incredibly tired & nauseous. Like a mix of morning sickness and the worst hangover of your life. I used the comfort meds for the entire 90 day ordeal. However, now 3 months after my treatment I am still hep free, and am living a normal healthy life. I have no lingering side effects. Mentally, it was refreshing...like the last trace of damage I had done while being in active addiction had been erased.. Like I now have a clean slate. It has been an incredible gift, despite the 90 days of wanting to throw up. I would 100% do it again. It was worth it.”

Was this helpful?YesNo
GratefulSeniorCitize · Taken for 1 to 6 months March 3, 2019

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “I just received the results from my final blood test, which is given 3 months after you finish EPCLUSA. The virus is gone, and I am cured of Hepatitis C! This medicine has given me my retirement back, and I am so grateful and blessed. Stick with it everyone, it's worth it!”

10 / 10
Was this helpful?YesNo
The cat November 10, 2019

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “I am Genotype 1a, 59 years old, male, active and otherwise healthy. I was diagnosed in 1995 but have not really suffered any ill affects of the virus other than mild liver enzyme imbalance. All of my fibroscans over the years have shown only minimal scarring. My doctor says Epcluza is a “perfect fit” for my situation so....I’m just starting my fifth week of treatment....no missed doses. As for side-affects I’m putting “extreme fatigue “ at the very top of my list. Nausea, headache and diarrhea come and go a bit but the fatigue and achy joints is up there. But...it is absolutely the right choice no matter the annoyance of these temporary yet fruitful ill effects. I say hang in there and enjoy the added years to your life. Love to all”

10 / 10
Was this helpful?YesNo
Fran · Taken for 1 to 6 months September 11, 2019

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “I’m on my 34th day of taking Epclusa, a little over 4 weeks, I thought I was going to be sick on my first two weeks, but I wasn’t just some tiredness and headaches off and on. Please,don’t worry about Epclusa, for me it’s been awesome, I wish I had done this forty years ago.”

10 / 10
Was this helpful?YesNo
A January 13, 2021

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “On my 2nd month with about 7 pills left. 3rd month was denied but I had to reach out to Gilead I think it was and they gave me a coupon. Instead of the $3,700 which I could not pay it will be 5 bucks for me thank goodness it worked out. 27 years old had hep c for about roughly 6 to 7 years. Was just test 3 days ago viral load is undetectable. My side effects Extremely tired so so so so tired Terrible headaches Random weird sores Ringing in ears Random neck pain Pain in lower back Extreme hunger in the am mixed with extreme sickness Some diarrhea Mood swings Irritability BRAIN FOG AND CONFUSION IS THE WORST itchiness I'm getting it all ways but in the end it's worth it. Also I get up at 2am everyday and work about a 10hr to 11hr shift of work and come home to my baby after and do not get to bed till 8 or 9 so I understand that is a lot on my body while fighting this also. Anyways hopefully this helps someone stay strong and keep fighting!!”

7 / 10
Was this helpful?YesNo
Angeltn · Taken for 1 to 6 months August 12, 2019

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “Take my last dose of Epclusa in the morning. I have to say the last week, I felt really tired but if I had to do it all over again, I would. I will be going to my doctor in two weeks and I will let everyone know the results. Before Epclusa I was a very sick person, in and out of the hospital every month. Since I started this med I have feel better, and not been in the hospital . I feel much better, dont hesitate in taking this medicine. Drink plenty of water and take a daily walk. I wish I had done this before my liver had been damaged. Happy with treatment.”

9 / 10
Was this helpful?YesNo
Havoc · Taken for less than 1 month July 19, 2019

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “This is my 2nd week on Epclusa. I caught the disease early with no liver scarring. I was terrified to begin treatment regardless of the positive reviews. The 1st week was rough but nothing compared to the free life I am headed towards. Day 1, nothing. Days 2 + 3 I had such unbearable fatigue and weakness I could hardly walk and required help from my family to get through the day. I was concerned that would be my life for the rest of the treatment and was afraid. Day 4 I spontaneously recovered but I was still weak, not alert. Day 4+ I RAPIDLY improved. Yesterday I felt better than even before I had started the medication, 0 side effects OR symptoms. I have night sweats but those are disappearing. I haven’t had nausea or headache, have had slight diarrhea. Those two days of despair were a small price to pay for the freedom I will get. Don’t fret about starting this medication. The first pill is your ticket to your new beginning.”

8 / 10
Was this helpful?YesNo
T · Taken for less than 1 month April 15, 2021

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “I found out in December 2020 that I have hep C - I know I had to have gotten it within the past 3 to 4 years! I just started taking Epclusa yesterday on 4/13/21. I decided to start taking it in the middle of the afternoon in case the side effects were bad. Last night about 8 or 9 hours after taking it I started feeling pain on the inside of my ankle joints and felt my feet start feeling tingly - it would be ok while walking around but the moment I sat or laid down I started feeling it . It helped to elevate my feet. I didn't have that feeling this morning but a few hours after taking it the feeling started happening again and this time I am also getting the pain in my left elbow joint. I hope and pray that it doesn't get worse but I am expecting to feel worse before I feel better ! I hope and pray everyone with hep C can get through treatment , be cured and never get it again! I will update again if side effects worsen.”

10 / 10
Was this helpful?YesNo
alex karis · Taken for 1 to 6 months June 1, 2021

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “I do not usually google side effects etc for fear of psychosomatic symptoms, but after 6 weeks on the drug I am losing my mind. It is a relief to read these reviews. Headaches (when I rarely had them prior) absolutely no energy. Weight loss - The nightmare begins when I try to sleep - sleep? LOL - massive insomnia. My feet and hands tingle resulting in my having to walk around. The tingling disappears when I move. Anxiety, Depression, unable to focus - I am on my way to secure a valium script :(”

1 / 10
Was this helpful?YesNo
Mandy · Taken for 1 to 6 months February 9, 2020

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “I’m almost 12 weeks on Epclusa and to say it’s been hard would be an understatement. I’ve been beyond tired- I’ve tried taking the medication both in the morning and at night. I’ve found that at night works best for me. I’ve become extremely irritable and depressed. I’ve also recently had this weird hormonal issue where my boobs hurt and I have acne (not even close to having my period nor pregnant). I never got any headaches or ear ringing so that’s a plus. I know it’s all going to be worth it in the end and I would not have done things any differently. For those of you reading through hundreds of reviews like myself- know that it will get better. I also have to take it for 3 months due to having type 3. Cheers to being hep c free. I received the medication for free through Support Path also Gilead. Look into it if you don’t have insurance!”

6 / 10
Was this helpful?YesNo
Britney6 October 29, 2016

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “I was so scared at first to start this med!!!! But I was so tired of feeling tired the first 2 weeks were rough!!!! Now almost 8 week in I feel great so much energy thank god and gilead for this med. oh iam gentype 2 for over 20 years having this crap. God bless and good luck to all.(:”

10 / 10
Was this helpful?YesNo
KellyAnne1 · Taken for 1 to 6 months November 23, 2016

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “I am on week 8 of a 12 week regime of Epclusa. The first couple of days I did have a slight headache, but since then I haven't had any side effects. I had blood work done at week 5. I was already undetectable! Thanks to a Epclusa coupon my copay is $5! Other side effects include: the whites of my eyes are white again! I have energy like I haven't had in 20 years. My skin is younger looking. I sleep like a baby. The slight depression that I used to feel from being so tired all the time is gone. I can get out of bed so easily now and feel energized throughout the entire day. It is hard to go to sleep sometimes because I still have so much energy. I am so thankful for this medication. This has given me quality of life again.Thank you Gilead!”

10 / 10
Was this helpful?YesNo
Blessed!! · Taken for 1 to 6 months December 27, 2020

Epclusa (sofosbuvir / velpatasvir) for Hepatitis C: “I’m on week 6 of Epclusa and other than the hairloss (I had ever since getting hep c almost a year ago) and ears ringing it’s not been bad for me at all. My first checkup my liver enzymes are back to normal and HCV is undetected. (Genotype 3 which is the hardest to treat) so I was so nervous about this not working. Hope it stays negative! I haven’t experienced no nausea and I take in morning without food. Will update later once I’m further into treatment”

10 / 10
Was this helpful?YesNo

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.