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Sofosbuvir / velpatasvir for Hepatitis C User Reviews

Brand names: Epclusa

Sofosbuvir / velpatasvir has an average rating of 7.8 out of 10 from a total of 336 reviews for the treatment of Hepatitis C. 66% of reviewers reported a positive experience, while 11% reported a negative experience.

Sofosbuvir/velpatasvir rating summary

7.8 average rating out of 10

336 ratings from 415 user reviews.

Compare all 21 medications used in the treatment of Hepatitis C.

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Reviews for Sofosbuvir / velpatasvir

  • Gra...
  • Taken for 1 to 6 months
  • June 14, 2021

Epclusa (sofosbuvir / velpatasvir) "Wanted to take this time and let everyone know about my experience. I started taking my Epclusa on March 22, 2021. Just finished my last dose tonight, June 13. I did not miss a day of work and worked out five days a week during the entire treatment. I have been virus-free since my first test at week four and have remained virus-free throughout. Will have my SVR test sometime in September. For those of you who are concerned about starting treatment, I found it to be a breeze and I am sure you will too! Thankful for this treatment as I am at stage 2/3 fibrosis and hopefully I will regress to a lower stage if not completely. Good luck to everyone getting ready to start, much God bless!"

10 / 10
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301 Report
  • Hay...
  • Taken for 1 to 6 months
  • July 4, 2021

Epclusa (sofosbuvir / velpatasvir) "I have finished my first bottle of Epclusa, and am now on week 5 of treatment. So far I’ve had no side effects that I have noticed, because I already had headaches and diarrhea before treatment. I had to stop taking my heartburn medication because of the drug interaction. I will get my first round of blood work this coming week and am very hopeful this medication has worked for me. It has honestly made me feel better about myself as a person. I am 3 years sober of IV Meth use and this was the one thing from my past I was still dragging around… hepatitis. I feel once this is over with I will have completely gained my life back."

10 / 10
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192 Report
  • Sto...
  • Taken for 1 to 6 months
  • January 19, 2021

Epclusa (sofosbuvir / velpatasvir) "I have 5 days left of Epclusa. The first two months I experienced some headaches and tiredness. This 3rd month is really taking a toll on me though. The headaches are worse, and I have no energy. I’ve felt too weak to even go to work for the past week. The worst part is I feel like I’m losing my mind. I don’t know if it’s depression or anxiety or what, but it’s definitely very difficult to function in a normal, healthy way."

7 / 10
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Frequently asked questions

  • Rod...
  • Taken for 1 to 6 months
  • October 30, 2019

Epclusa (sofosbuvir / velpatasvir) "I just want people to know that when the Epclusa is killing the Hep C virus in your body, you're probably going to feel a little nausea. The virus is multiplying millions of times in your body - there's a war between the Epclusa and the Hep C. Just hang in there, you'll be glad when the 12 weeks are over. God bless."

10 / 10
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  • AWa...
  • Taken for 1 to 6 months
  • April 11, 2021

Epclusa (sofosbuvir / velpatasvir) "Think about it, people! How many of you received this medicine free, or better yet, my company insurance paid 80 percent of $72,000. Guess where the other came from? A coupon that Epclusa provided. Ever heard of that before? It's been 15 months since I finished my last pill. My stomach looks as if I have cirrhosis, it feels like I have an infection in my stomach, I'm like the other lady states about hormonal issues. I'm 65 and started having acne. I'm extremely depressed. I've developed major arthritic symptoms. This drug has cured the hep C but my day-to-day journey is horrific. I do not recommend this drug. Your doctor will tell you there are no side effects. How do they really know? I'll never listen to any doctor again. When any medication has only been around for a short period, don't label it as no side effects. Hope your doctors and drug manufacturers can sleep good at night because you won't!"

1 / 10
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  • Bla...
  • Taken for 1 to 6 months
  • September 6, 2019

Epclusa (sofosbuvir / velpatasvir) "Well, on my first review on July 28, 2019, I said I'd come back after a bit. Now I am just over halfway through my treatment. I get what you all say about tinnitus. Also, when I wake up in the morning, I'm the same with feeling rough. But once I've had a coffee, it dies down. My feet have been aching a bit, as has my back, but I've had no sickness or headaches. I think that if you have a life-threatening disease like hep C, which is never going away, then it's like carrying bad luggage around every day. If you get a chance to get rid of it and there are a few side effects that are quite manageable, then it's got to be worth it. I felt okay apart from brain fog at first, but it's got a bit worse as I've gone on with meds. But I am more than willing to suffer these for 12 weeks than stay sick forever. I hope you all have the best time on Epclusa that you all can and become hep C free. Take care, people."

8 / 10
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  • She...
  • February 12, 2021

Epclusa (sofosbuvir / velpatasvir) "Started Epclusa in March 2019 for Hep C type 2b. I ate small items/meals throughout the day. Stayed hydrated and avoided any caffeine. Took the pill at 6 am with a piece of bread. I was on an extreme health regime while taking it. Didn't experience anything terrible. However, after the treatment was over, any form of caffeine gives me a 3-day migraine. I am more sensitive to all chemicals in food and drink and get headaches easily, including from fructose and sugar in small amounts. Before Epclusa, I only got headaches when trying to cut back on coffee due to caffeine withdrawal. I noticed that my adrenals and emotions seem to escalate quickly. While I am happy that Epclusa cured my hep C, it also significantly changed my life. It is now January 2021, and I still experience these symptoms. I am very hesitant to get the Covid-19 vaccination due to the headache side effect as I fear my head may explode. Hope this information helps someone."

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More FAQ

  • Gra...
  • Taken for 1 to 6 months
  • November 9, 2020

Epclusa (sofosbuvir / velpatasvir) "I was an intravenous drug user from age 19 to 32 years old. Clean from all drugs from February 1, 1988, to present. I have had hepatitis from age 19 to 65 years old and 6 weeks on Epclusa with nondetectable test. I had hep C genotype 1A. So grateful for Epclusa. It has allowed me to live longer than expected and 6 more weeks until treatment is completed. Very mild side effects (headache, mood swings, and light depression) so far. At the age of 45 to 50, I did interferon/ribavirin 3 separate times and never was able to finish due to terrible side effects. Epclusa will and is going to save my life. Thanks to everyone that made this happen."

9 / 10
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  • Rod...
  • Taken for 1 to 6 months
  • December 20, 2019

Epclusa (sofosbuvir / velpatasvir) "I live in southeast Missouri. I'm beginning my 3rd month on Epclusa. Just went in to get my blood results, my Hep C virus is gone. Still got one more month of treatment. I've had zero side effects. This medicine is a lifesaver."

10 / 10
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  • The...
  • November 10, 2019

Epclusa (sofosbuvir / velpatasvir) "I am Genotype 1a, 59 years old, male, active, and otherwise healthy. I was diagnosed in 1995 but have not really suffered any ill effects of the virus other than mild liver enzyme imbalance. All of my FibroScans over the years have shown only minimal scarring. My doctor says Epclusa is a 'perfect fit' for my situation. I’m just starting my fifth week of treatment, with no missed doses. As for side effects, I’m putting 'extreme fatigue' at the very top of my list. Nausea, headache, and diarrhea come and go a bit, but the fatigue and achy joints are up there. But it is absolutely the right choice, no matter the annoyance of these temporary yet fruitful ill effects. I say hang in there and enjoy the added years to your life. Love to all."

10 / 10
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  • And...
  • Taken for 1 to 6 months
  • August 16, 2020

Epclusa (sofosbuvir / velpatasvir) "I was diagnosed with Hep C. I was prescribed Epclusa. From the very first tablet, I felt something working inside. Within one month, my count was down from millions to low numbers. The course was completed, and I am now Hep C free. No side effects whatsoever. Thank you Gilead and the NHS!"

10 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • June 18, 2019

Epclusa (sofosbuvir / velpatasvir) "The first 3 weeks of using Epclusa was insane... I was incredibly tired & nauseous. Like a mix of morning sickness and the worst hangover of your life. I used the comfort meds for the entire 90-day ordeal. However, now 3 months after my treatment I am still hep-free, and am living a normal healthy life. I have no lingering side effects. Mentally, it was refreshing... like the last trace of damage I had done while being in active addiction had been erased. Like I now have a clean slate. It has been an incredible gift, despite the 90 days of wanting to throw up. I would 100% do it again. It was worth it."

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  • Ash...
  • Taken for 1 to 6 months
  • February 11, 2020

Epclusa (sofosbuvir / velpatasvir) "I gave blood and found out I was Hep C positive! Been on Epclusa for 2 months and didn’t have any side effects until month 2 when I started itching all over and noticed some random big bruises on my legs! Called the doctor and they ran tests and found out my test for Hep C is negative, all thanks to this medicine! Only one more month! Stay strong, y’all!"

10 / 10
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101 Report
  • Jef...
  • Taken for 1 to 6 months
  • April 23, 2021

Epclusa (sofosbuvir / velpatasvir) "I just finished my 12th and final week of taking Epclusa one week ago. I probably got Hep C in the Army during the early 1970s. I am now 68 years old. These are the side effects that I noticed: Brain Fog. Just not able to think clearly and rationally. Insomnia. I had to get medication to sleep. My normal libido was gone soon after starting Epclusa. I have had no sex with my wife or even the slightest desire to have sex. I will not know if the Epclusa got rid of the Hep C for another 3 weeks when I have the first Blood Test. Currently, I am just wondering if I will ever feel normal again. I still feel like I am on the Epclusa. Talking to my doctor is a waste of time. She does not believe that Epclusa caused any of the problems that I am having."

5 / 10
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  • Kel...
  • Taken for 1 to 6 months
  • November 23, 2016

Epclusa (sofosbuvir / velpatasvir) "I am on week 8 of a 12-week regimen of Epclusa. The first couple of days, I did have a slight headache, but since then, I haven't had any side effects. I had blood work done at week 5. I was already undetectable! Thanks to an Epclusa coupon, my copay is $5! Other side effects include: the whites of my eyes are white again! I have energy like I haven't had in 20 years. My skin is younger-looking. I sleep like a baby. The slight depression that I used to feel from being so tired all the time is gone. I can get out of bed so easily now and feel energized throughout the entire day. It is hard to go to sleep sometimes because I still have so much energy. I am so thankful for this medication. This has given me quality of life again. Thank you, Gilead!"

10 / 10
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  • Aan...
  • January 13, 2021

Epclusa (sofosbuvir / velpatasvir) "On my 2nd month with about 7 pills left. 3rd month was denied, but I had to reach out to Gilead, I think it was, and they gave me a coupon. Instead of the $3,700, which I could not pay, it will be 5 bucks for me, thank goodness it worked out. 27 years old, had hep C for about roughly 6 to 7 years. Was just tested 3 days ago, viral load is undetectable. My side effects: Extremely tired, so so so tired. Terrible headaches. Random weird sores. Ringing in ears. Random neck pain. Pain in lower back. Extreme hunger in the morning mixed with extreme sickness. Some diarrhea. Mood swings. Irritability. BRAIN FOG AND CONFUSION IS THE WORST, itchiness. I'm getting it all ways but in the end, it's worth it. Also, I get up at 2 am every day and work about a 10 to 11-hour shift and come home to my baby after and do not get to bed till 8 or 9, so I understand that is a lot on my body while fighting this also. Anyways, hopefully this helps someone stay strong and keep fighting!!"

7 / 10
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75 Report
  • Gra...
  • Taken for 1 to 6 months
  • March 3, 2019

Epclusa (sofosbuvir / velpatasvir) "I just received the results from my final blood test, which is given 3 months after you finish Epclusa. The virus is gone, and I am cured of Hepatitis C! This medicine has given me my retirement back, and I am so grateful and blessed. Stick with it everyone, it's worth it!"

10 / 10
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96 Report
  • Ter...
  • Taken for 1 to 6 months
  • June 6, 2022

Epclusa (sofosbuvir / velpatasvir) "I've not been the same since taking this horrible drug. I asked about the side effects before deciding to take it and was told only temporary headache, nausea, etc. What they did not mention was the permanent irritability and/or depression. No good feeling ever. It's been almost 3 years. I did not take the 3rd month as these effects were too severe. Did it cure my new Hep C? I don't know, and frankly, don't care. Please be wary of new drugs and try to find all the 'post-market side effects.'"

1 / 10
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  • Skp...
  • June 5, 2019

Epclusa (sofosbuvir / velpatasvir) "I pray for all of you that the symptoms you feel go away. All of mine have stayed with me since 2017. I am damaged inside my body, inside my brain, and all of these doctors all say the same thing - there's no way Epclusa could have done this. I hope all of you get through this and your symptoms to go away, but mine stayed with me and I feel like I'm going crazy every day. Every day I feel more alive in my dreams than I do when I'm awake. Now I have constant pain in my knees, constant brain fog, everything hurts, I have no digestion, I have no colon that works anymore, it has messed everything up inside of me. It did get rid of hep C, but in my opinion, it messed me up. I would not tell anybody to take this medication. This medication is the same thing as Harvoni with just an extra medicine in it. I pray for all of you taking this medicine. If my hep C comes back, I will never try treatment again."

1 / 10
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89 Report
  • Jac...
  • Taken for 1 to 6 months
  • March 25, 2021

Epclusa (sofosbuvir / velpatasvir) "I would not recommend this drug at all, I was fine before I took it. It's been 2 years, and I am getting worse. First, I got a rash on my head when I started taking it, yeast infections for months. Five months later, the rash started on my feet, they were on fire. Now the rash is all over my legs, it looks like I was beaten up. The side effects are not worth it at all, I don't trust doctors, and this drug needs to be stopped! I know what big pharma is all about: money. After researching, I am hoping I get to use better medicine to reverse the damage done!"

1 / 10
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64 Report
  • Ang...
  • Taken for 1 to 6 months
  • August 12, 2019

Epclusa (sofosbuvir / velpatasvir) "Took my last dose of Epclusa in the morning. I have to say, the last week, I felt really tired, but if I had to do it all over again, I would. I will be going to my doctor in two weeks, and I will let everyone know the results. Before Epclusa, I was a very sick person, in and out of the hospital every month. Since I started this med, I have felt better and haven't been in the hospital. I feel much better, don't hesitate to take this medicine. Drink plenty of water and take a daily walk. I wish I had done this before my liver had been damaged. Happy with the treatment."

9 / 10
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84 Report
  • Fra...
  • Taken for 1 to 6 months
  • September 11, 2019

Epclusa (sofosbuvir / velpatasvir) "I’m on my 34th day of taking Epclusa, a little over 4 weeks. I thought I was going to be sick in my first two weeks, but I wasn’t. Just some tiredness and headaches on and off. Please, don’t worry about Epclusa. For me, it’s been awesome. I wish I had done this forty years ago."

10 / 10
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79 Report
  • Bri...
  • October 29, 2016

Epclusa (sofosbuvir / velpatasvir) "I was so scared at first to start this med! But I was so tired of feeling tired. The first 2 weeks were rough! Now, almost 8 weeks in, I feel great, so much energy, thank God and Gilead for this med. Oh, I am genotype 2 for over 20 years having this. God bless and good luck to all. :)"

10 / 10
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102 Report
  • Mar...
  • Taken for 1 to 6 months
  • December 15, 2021

Epclusa (sofosbuvir / velpatasvir) "I thought my 12-week treatment on Epclusa was going really hard on me. Apparently, I had had Hep C in my body with no symptoms for 45 years from a blood transfusion. Was tested for it in routine tests and then had a liver biopsy, which showed only level one liver damage. I had, during treatment, and still suffer from extreme fatigue, memory issues, and insomnia. If I had ever dreamed how my life would change for the worse, I would never have taken the first pill! The only positive is that I am now free of Hep C, which I had apparently had for 45 years without symptoms. I am 79 years old and believe I could have lived the remaining years of my life without Epclusa!"

3 / 10
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  • Hep...
  • Taken for 1 to 6 months
  • October 2, 2021

Epclusa (sofosbuvir / velpatasvir) "Finished taking Epclusa 1/3/2019. Almost two years later, I continue to have severe side effects. I had always been an extremely high-energy person, working and on the go for 16 plus hours a day. Since taking Epclusa, I continue to experience severe fatigue, memory loss (brain fog), and tinnitus. I have not been able to return to work since Epclusa. At this point, it appears that I traded a shorter but quality life with Hep C for quantity of life that's only watching it pass by. I'm continuing to search for answers for something to help restore my health. If I had known what the results would be, I would probably not have taken the Epclusa."

1 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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