Selexipag and Muscle Pain: What Users Say

• JuC...
• Taken for 1 to 6 months
• March 6, 2019

For Pulmonary Arterial Hypertension "I started at 200 mcg on 2/7. Side effects escalated, so by the next titration of 400 mcg, I was in so much pain, it hurt to move, and my jaw pain was ridiculously annoying. I never experienced muscle pain like this before. I told my nurse when he came. I was supposed to go to 600 mcg, but they set me back at 200, which is where I still am. If I didn’t have severe side effects, I’d already be at 1200 mcg. The good part is that I found that I breathe a lot better and had more energy. Even my cough wasn’t as bad. The downside is that I began to have diarrhea, and that sucks. The pain of diarrhea, not being able to eat, absolutely no appetite. What do I do? Imodium isn’t working. I’m stuck in the house. Sorry to say the good doesn’t outweigh the bad, and I’d rather not be on this medicine."

• Neg...
• Taken for 6 months to 1 year
• January 16, 2020

For Pulmonary Arterial Hypertension "Been on Adcirca and Letairis since April 2018. Started Uptravi in May 2019. 200 mg was okay, felt somewhat of an improvement in my ability to walk longer distances. Moved to 400 mg, was very hard and painful, muscle pain in the legs, heels, jaws, headaches. Went back to the 200 mg dose and stayed with it for a month. Then started going up again in smaller steps, first increased the evening dose, then a week (sometimes two weeks) later, the morning dose. Got to 1,400 mg but had to step back to 1,400 mg at PM and 1,200 mg at AM. Plan to continue increasing after some more time. Taking also Tylenol almost every day and sometimes Advil for the constant headaches. Pressures for me, so far stayed the same, more or less. Didn't feel I was getting stronger, in fact, the last 6-minute walk I had a drop. Is it worth it? I don't know. The other alternatives are pumps, so better to try pills before using pumps..."

• Mem...
• Taken for 1 to 2 years
• June 27, 2020

For Pulmonary Arterial Hypertension "I started taking Uptravi in 2019. I made it up to 800 mcg before the muscle pain became intolerable. My breathing has improved, but I’m on other medications as well. I have tapered down to 400 mcg because of the pain. It still hurts, and overall, it makes my body feel extremely uncomfortable. It’s not good to take Tylenol or ibuprofen every day either. Honestly, I don’t remember the ibuprofen relieving the pain. I know one thing: I don’t believe God would use something that causes us pain to make us better."