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Secnidazole and Nausea: What Users Say

Brand names: Solosec

Nausea: mentioned by 54 users (36.2%)

Based on user experiences from 149 Secnidazole reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 36.2%
vomiting 19.5%
bad taste 14.1%
headaches 10.7%
metallic taste 5.4%
yeast infection 5.4%
diarrhea 4.7%
upset stomach 4.0%
fatigue 3.4%
dizziness 2.7%

Reviews for Secnidazole

Commonly mentioned side effects
  • tre...
  • Taken for less than 1 month
  • September 2, 2020

For Bacterial Vaginosis "I have chronic BV/yeast infections, and this is the only drug that works. Within the first 6 hours, I already can tell a difference in discharge/itchiness/smell, and within 24 hours, I have total relief. HOWEVER, I MUST warn anyone who is going to take this drug: DO NOT DRINK ALCOHOL. The packaging says it's OK, but it is a horrible experience. I drank a glass of wine 6 hours after taking the medication, and I was violently ill - vomiting and nauseous for 10 hours. I was vomiting up chemicals and bile - it is NOT worth it."

8 / 10
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  • Sof...
  • Taken for 6 months to 1 year
  • June 3, 2020

For Bacterial Vaginosis "I decided to write a positive review because I always get scared away by negatives, and then I remember, most people don’t write reviews when they’re satisfied! So this is the second time I’ve taken Solosec for BV. I get BV every few months. Yes, the taste is bad, but I just added some cinnamon to my applesauce and swallowed big spoonfuls, and within a minute, I was done. I have a lot of health issues, although I’m young, and most of them are digestive/gastrointestinal, so certain side effects are a concern for me (diarrhea, nausea, etc.). Last time I took it, I had horrible cramping pretty soon after taking it and had a couple of episodes with diarrhea before it settled down. I was fine. This time, no side effects so far (took it 5 hours ago). It cost me $25 last time with a coupon and $10 this time with my insurance, which seems odd to me, but doesn’t matter. It cured every symptom in 24 hours last time, so I’m hopeful for this time too!!"

8 / 10
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  • Alm...
  • Taken for less than 1 month
  • March 14, 2020

For Bacterial Vaginosis "I took this medication, Solosec, on a Monday, it is now Friday. Yes, the taste was horrible, but I managed by eating it fast and drinking water. Within 24 hours, the smell and discharge were gone. I read the reviews about staying away from alcohol and do so for 5 days. I drank 2 good glasses of wine tonight. I don’t feel like throwing up, but I definitely feel like something is rumbling. I thought 5 days would be okay, but maybe I should have tried 7. All in all, this is a great product that I would recommend."

9 / 10
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  • Man...
  • Taken for less than 1 month
  • May 19, 2020

For Bacterial Vaginosis "I took this on Thursday morning, definitely gross tasting and had a minor headache and a little bit of nausea, but nothing crazy. I avoided alcohol because of the reviews. It is now Monday evening and I had my first beer, and I don't feel sick or anything. It says on the website that it stays in your body for four days, so I think don't drink for four days just to be safe! All in all, it worked for me and smell, etc., was gone after 24 hours. Pretty pleased with the meds."

8 / 10
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  • Tin...
  • Taken for less than 1 month
  • September 28, 2019

For Bacterial Vaginosis "I took the medicine 9/27/19. Whoever said that this medication doesn't change the taste of food needs to be fired. Well, I guess in a sense it doesn't. But the granules themselves taste horrific. Once I got past the initial urge to chew, swallowing about 6 tablespoons of yogurt, I made it through. I waited patiently for the nausea, vomiting, upset stomach, etc. Fortunately, I haven't experienced any of that as of yet. It's been 24 hours, and I already feel better. I will say that I didn't do what everyone else did and drink alcohol. Regardless of what the packet says, you should know better than to drink alcohol with an antibiotic. That being said, I'd much rather stomach this one-time nasty stuff than to take a pill twice a day for seven days."

7 / 10
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  • Man...
  • October 30, 2019

For Bacterial Vaginosis "I have heavily researched BV, which I have been plagued with for about 7 years now. No explanation from docs. Prescribed this, and the co-pay for Solosec was $100. But I was desperate. Mixed with a cup of applesauce, texture/taste was tolerable, took at 3 pm, by 6:30 pm the same night had a headache, also had 1.5 glasses of wine since trial studies showed no contraindication. By 9:30 pm I was nauseous. Then, 10:30 pm, puked. I felt fine afterward, was able to sleep all night and woke up fine. My symptoms have gone. I will update this review in a few months. I am hoping Solosec will cure my recurrent BV infections for good. Sick of living like this. Apparently, it is supposed to cure most drug-resistant BV cases. We’ll see. I can deal with a headache and puking for one night vs. having to take a 7-10 day antibiotic, get a yeast infection, can’t have a drink, all for BV to come back. Benefits outweigh risks in my opinion."

8 / 10
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  • Why...
  • July 31, 2019

For Bacterial Vaginosis "As a diabetic, I get yeast infections often, however, this one was different. I didn't itch or get the whole cottage cheese combo, but it was more like a bladder leak. I had been off my diabetic meds during a time when I was laid off without insurance. So, when I started the medication again, it hit my privates: UTI, yeast infections, and finally the BV. You have not been embarrassed until your 3-year-old nephew asks, 'What's that smell?' So I made the appointment with my doctor, and she tells me about this wonder drug, Solosec. I dumped it in chocolate pudding, gave it a whirl with my spoon, and 3 bites later it was gone. Now, there was some deep breathing and prayers being sent up during each bite, but I made it. That was yesterday at 8:30 pm. And as of right now, no headache, nausea, or vomiting. My privates are not sweating today, and my inner thighs are not chafed. So, yes, I would take this medication again."

7 / 10
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  • Ano...
  • Taken for less than 1 month
  • June 20, 2019

For Bacterial Vaginosis "First experience with BV at 43 years old, recently had my gallbladder removed, so wasn't sure if the issues came from that. Dr. prescribed Solosec for me, reading these reviews last night made me scared to try ALMOST. I went today and got the medicine and took it at work. I did eat something and took it with a dairy-free yogurt. No upset stomach, no nausea, slight headache but could be from my hair in a bun. Overall, the taste was terrible but manageable to get down and no aftertaste. I took a few bites of yogurt, then drank water, continued until completely gone. Then had my salad and finished the bottle of water. No issues since 10:45 am and it is 6 pm now, so far so good but anything is better than the infection. Suggestions: no alcohol as it seems to make the medicine symptoms worse per the reviews and definitely eat something."

8 / 10
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  • Ell...
  • Taken for 1 to 6 months
  • December 13, 2019

For Bacterial Vaginosis "I have read many of these reviews and wonder if the people without these experiences just don't report it. I thought there was no taste to the medicine, just have to fight the urge to chew. A couple sips of water to rinse the rest out of my teeth was all that was needed. No metallic taste, nausea, fatigue, or any of the other side effects mentioned. I will, however, not chance the alcohol. This is the 2nd time I've used Solosec and have had good results. Also, only a $10 copay at the pharmacy my doctor recommended."

10 / 10
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  • Col...
  • Taken for less than 1 month
  • May 31, 2022

For Bacterial Vaginosis "I didn’t even know I had BV until an annual pap in April. Pill and gel form Flagyl did not work for me. My doctor gave me some Solosec to try. I put it in yogurt (could barely get it down, was so disgusting and NO, I did not chew). I slept for 12 hours after taking it because it made me so tired. The next day, I felt nauseous and lightheaded. I also had blurry vision. The burning and pain after peeing went away for 2 days. I’m now on day 3 after taking this, and the burning and pain is back. I also have green discharge now. I think it might’ve worked for a minute, but didn't get the infection all the way. *sigh* Almost wish I never went to get my annual pap because my vagina didn’t hurt until treatments."

3 / 10
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  • Rin...
  • March 10, 2020

For Bacterial Vaginosis "I took Solosec Sunday with applesauce (it is now Tuesday), and it was GROSS, so much so it left a bitter taste in my mouth for a while. I wouldn't necessarily recommend it, but I also wouldn't not recommend it (to each its own). It does seem to be working as far as treating my BV. No odor, discharge, itching, etc. I tried this method for treating my BV because it's only a one-time dose, but if it was to come back (I really hope it doesn't), I would not want to take this again. The taste, nausea, and cost are a no from me."

5 / 10
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  • Anonymous
  • Taken for less than 1 month
  • July 16, 2019

For Bacterial Vaginosis "I took Solosec around 3 pm yesterday, and 24 hours later I have already seen a major improvement. I feel like people are being a little dramatic about the taste, I mixed it with a yogurt parfait from McDonald's, and I did not taste a thing. However, even though it says it’s okay to drink while on this medicine, I strongly do not recommend it. I drank around noon, it is currently 6 pm, and I have thrown up around 3 times today, plus I still feel incredibly nauseated. I’m able to eat, but it is not helping to reduce the nausea. But overall, had I not had anything to drink, this would have been a very positive experience."

7 / 10
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  • Vno...
  • Taken for less than 1 month
  • November 5, 2020

For Bacterial Vaginosis "I was prescribed this because I developed BV/yeast infection from being on weeks of antibiotics for other issues. I mixed the many granules in my vanilla pudding, but trying to eat this was a regrettable experience. The bitter taste got worse as I swallowed, and trying to finish it made me close to vomiting. After, I began developing tremors and felt queasy for the rest of the night. At this point, I should mention I also have GERD/digestive issues, so while the average person could probably down this better, my mouth was quite bitter to begin with and made it much more difficult to swallow this awful concoction. I also find this hasn’t really done anything to help 18 hours later. In fact, it’s making my stomach feel worse and my infection is still on fire. For those sensitive to medication like me or have other health issues, I do not recommend this at all."

2 / 10
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  • Boc...
  • September 5, 2020

For Bacterial Vaginosis "My lady part issues began when I was prescribed Levaquin (an awful antibiotic drug) before a surgery. That kicked off the nightmare journey I’ve been on for a year with nonstop yeast infections and BV. Solosec was prescribed to me since the cycle between getting rid of the BV would promote yeast and a never-ending cycle, and my body is becoming resistant to the antibiotics. I’m 24 hours into taking the Solosec prescription, and what others are saying is true. It tastes terrible, and you have these medication grains in your mouth that are bitter. It was a Friday, and I decided to have a cocktail, and since the instructions say it doesn’t cause issues with alcohol, I figured I was fine. Wrong. I spent hours throwing up (and it was one cocktail) and the entire next day in bed recovering from dehydration and the aftereffects of being so sick that the deepest bile and chemicals were coming out. I will NOT take this drug again."

5 / 10
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  • Aub...
  • August 29, 2020

For Bacterial Vaginosis "I took this Solosec with chocolate pudding two days ago, and I have been extremely nauseous and dizzy, so horrible that I can barely lift my head off a pillow. I’m shaking and freezing and aching, tingling all over my body. I have the worst headache, and it is even worse the second day than yesterday. I would not recommend this to anyone. I wish I never took it. I don’t know when this is going to stop, but I hope to goodness it’s soon. I’ve had this once before five years ago, was given a single pill, and I never felt a thing from it, and it went away immediately for five full years. I just had a miscarriage, and they did a swab; it came back with BV, so my doctor suggested this is the best thing on the market. My insurance covered it, but it was still $135. Do not take this, people! There are plenty of other options. ;("

1 / 10
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  • Bea...
  • Taken for less than 1 month
  • December 29, 2020

For Bacterial Vaginosis "I never write reviews, but I feel compelled to do so. This is absolutely the worst medication I have ever taken. Immediately after taking the medication, I started feeling nauseous. I’ve been having the most painful headache, nausea, and diarrhea. I feel so dehydrated and have drunk over 64 ounces of water in just a few hours. I am hoping that it will flush this medication out of my system."

1 / 10
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  • Anonymous
  • September 23, 2019

For Bacterial Vaginosis "Very bitter taste to it, took it with yogurt and had to swallow it down. Woke up with a metallic taste in my mouth. Made everything taste off, had a headache each day for 4 days, bloated, and nauseated. On day 3, I had 2 Coronas and we BBQ'd some hamburgers for dinner. 2 hours later, I was projectile vomiting my dinner. I felt better once I had vomited, but I was down the rest of the night. I thought maybe it was bad beef, but no one in my family got sick. I felt pregnant (which I'm not) or flu-like symptoms. I would not take this again as there are other Rx out there that can help with BV. Yes, the BV is gone, but feeling sick for 4-5 days was too much for me."

4 / 10
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  • Tif...
  • Taken for less than 1 month
  • October 25, 2019

For Bacterial Vaginosis "So I don’t think the taste is bad. Didn’t bother me at all. What bothers me is the awful side effects. For the past 3 days, I’ve had a migraine headache that won’t go away, extreme nausea, and fatigue. I've also developed a rash, but I'm unknown if it’s related. It cured my BV, BUT the negatives completely outweigh the positives. I will NEVER take this medication again."

2 / 10
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  • Sam...
  • February 28, 2020

For Bacterial Vaginosis "I was prescribed this medicine for BV but never heard of it before. My doctor gave me a coupon to get this medication for $25 and warned me that sometimes women develop a yeast infection in about 4 or 5 days after taking it. So she prescribed me yeast infection medication with it just in case. I also asked my doctor if I could drink alcohol on the same day or days after taking it. I mixed it with applesauce and really didn’t notice a taste at all. I took it on a Monday, had 2 beers later that evening, and during the 3rd, got extremely nauseous and a horrible headache. I had to lay down, and the symptoms lasted for at least 3 or 4 hours. My BV symptoms started to go away, and I felt so much better, but now it’s 5 days later on Friday, and it feels like it’s back. Definitely not a yeast infection as I have no discharge and no itching. I would have given 10 stars if it had worked. It was so much better than choking down the normal horrible-tasting horse-sized antibiotics."

5 / 10
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  • Pro...
  • July 12, 2019

For Bacterial Vaginosis "I was prescribed Flagyl, but when I asked for something with fewer doses and no contraindication to alcohol, as I had an upcoming event involving cocktails, she prescribed this medicine, Solosec. She warned me about the taste but assured me it was completely safe to consume alcohol with this medication. I mixed it in 3 tablespoons of raspberry yogurt, swallowing each spoonful quickly and chasing it with water. Not terrible at all. This was around 1 pm. I had a few drinks between 6:30 and 9 pm. I was very nauseous by 9:30, and by 10 I was RUNNING to the bathroom. It started with explosive diarrhea, leading to drenching sweats that had me stripping off my clothes in the bathroom just in time to bury my head in the trash can. This went on and on the entire night. I felt like I was going to die! It is now 4 pm the next day, and I have barely managed a few crackers and ginger ale, I haven't left the couch for more than a few minutes. Needless to say, I will never take this medication again."

1 / 10
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  • Mic...
  • Taken for less than 1 month
  • November 6, 2020

For Bacterial Vaginosis "I was very optimistic about this drug even after reading some reviews. I took the packet with yogurt, and I ended up finishing it all somehow. I felt nauseous the whole time trying to eat it. About a minute after finishing, I projectile vomited all of the medication. What a waste of $90 and my hopes of being BV free."

1 / 10
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  • AWa...
  • Taken for less than 1 month
  • November 15, 2019

For Bacterial Vaginosis "I made the mistake of reading reviews AFTER I had already consumed the medication and was super worried about side effects. I, fortunately, had very few. The medicine does not taste nearly as awful as some of these reviews portray. It doesn't taste great (it's bitter like crushed aspirin or Tylenol), and I wouldn't eat it on its own, but it's totally manageable in yogurt. I had a metallic taste in my mouth and experienced a bit of nausea and was aware of my stomach for the first 12 hours or so, but it wasn't horrible and I was fine when I woke up the next morning. I've not tried to drink alcohol and probably will not based on some of the other reviews. But this definitely was easier than messy creams or remembering to take a pill 2x a day for a week."

7 / 10
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  • Sim...
  • March 1, 2020

For Bacterial Vaginosis "It didn’t work for me at all. What a waste of time and money. It left me with a yeast infection, a nasty taste in my mouth, and nausea. Once I was off my period, back to the smell. I’ll just stick to boric acid suppositories in the meantime."

1 / 10
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  • Sal...
  • Taken for less than 1 month
  • October 4, 2019

For Bacterial Vaginosis "I have had a terrible experience with this drug. I thought it would be tasteless and poured it into yogurt. I struggled to swallow yogurt without crunching the granules and resorted to swallowing yogurt with water. The taste was so unbearable that I almost started vomiting right then and there, but the drug cost $45, and I did not want to waste it. I enjoyed the bowel prep before a colonoscopy above this taste! Instantly, I developed a strong migraine as if I took nitro under my tongue, but the headache never left, and I had associated nausea. It stopped my life. My oldest daughter had to call off work to take care of me and find a babysitter for my youngest as I could not care for her. It was as if I had the flu with a migraine. This drug should be researched more. It made me way too sick just to try to cure a BV infection. I would have rather had a 7-day treatment that did not cause so much sickness and disrupt my life."

2 / 10
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  • Pha...
  • April 9, 2019

For Bacterial Vaginosis "CAUTION, BE VERY CAREFUL! I have always had a sensitive stomach, but have never had issues with Flagyl. Being that this is in the same family, I assumed it would be no different. Boy was I wrong! I took Solosec Monday night at approx 6 p.m., in pudding. As the night wore on, I began to feel crummy, nauseous, and off, so I decided to go to bed. About 1 a.m., I woke up, bolted to the bathroom, tripping over pillows, dogs, and whatever else, to barely make it to the toilet before projectile vomiting. The rest of the night was more of the same. By morning, I was still feeling badly, so I decided to call my doctor's office and let them know. It is now 1 p.m. on Tuesday, and I had to leave my desk (I work from home) and go lie down. I’m still nauseous, have no appetite, and just feel off, but I’m hoping this feeling will go away soon. I can tell you this: I will NEVER take this stuff again! One-day cure or not, I’ll stick with my Flagyl!"

1 / 10
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