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S-adenosylmethionine and Panic Attacks: What Users Say

Brand names: SAMe, Natrol SAMe, Adomet

Panic attacks: mentioned by 3 users (6.4%)

Based on user experiences from 47 S-adenosylmethionine reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

anxiety 17.0%
nausea 14.9%
dizziness 10.6%
vomiting 8.5%
gi issues 6.4%
irritability 6.4%
panic attacks 6.4%
vivid dreams 6.4%

Reviews for S-adenosylmethionine

Commonly mentioned side effects
  • Blu...
  • Taken for less than 1 month
  • August 5, 2018

For Depression "At the recommendation of my doctor, I started taking SAM-e for depression. She recommended 400 mg, 2x a day without food. I had to immediately stop the PM or before-bed dose as it was too activating for me. I have sleep issues as well and noticed that after taking it, I was waking up several times a night and staying awake. I stayed on the AM dose for about three weeks and eventually had to stop that dose as well due to increased anxiety, panic, and agitation. It sounds from the other reviews like this is a great supplement for those who do not have co-occurring anxiety."

5 / 10
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84 Report
  • TBo...
  • Taken for 1 to 6 months
  • November 2, 2019

For Depression "After 20 yrs of antidepressants and anti-anxiety meds, I decided to give Sam-E (s-adenosylmethionine) a try. It really helps with moderate depression. Does not help with anxiety. Tried it for several months until I realized it was giving me panic attacks and insomnia."

8 / 10
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59 Report
  • Vio...
  • Taken for less than 1 month
  • October 13, 2020

For Herbal Supplementation "I started on SAM-e 3 weeks ago and started to have severe weakness, joint pain, exhaustion, and panic attacks. This was prescribed by my naturopath for pyroluria, but I am stopping it today. I took my anti-anxiety meds with it and felt like I was going crazy. Not a good combo with antidepressants or anti-anxiety meds. But, we’re all different. Hoping this clears from my system fast."

1 / 10
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44 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.