S-adenosylmethionine and Irritability: What Users Say

• Blu...
• Taken for less than 1 month
• August 5, 2018

For Depression "At the recommendation of my doctor, I started taking SAM-e for depression. She recommended 400 mg, 2x a day without food. I had to immediately stop the PM or before-bed dose as it was too activating for me. I have sleep issues as well and noticed that after taking it, I was waking up several times a night and staying awake. I stayed on the AM dose for about three weeks and eventually had to stop that dose as well due to increased anxiety, panic, and agitation. It sounds from the other reviews like this is a great supplement for those who do not have co-occurring anxiety."

• mma...
• September 18, 2020

For Depression "I tried SAM-e a few years ago after my dad died. (200-400 mg morning huge glass of water) It was amazing, worked really quick, and I found the years of intermittent depression vanished (took for a few months). I weaned off and was fine until I started perimenopause symptoms, so I thought I would try again and see if it would help the lows and highs. It's only been a week, and it has stabilized them (also taking 300 mg magnesium). It's also helped my joint pain significantly, but it hasn't helped the anxiety, and I have bad bloating. The first few days, I was agitated, dizzy, and felt a bit manic, but I remember that from last time, and it settled now after a week. I am going to keep taking it for the joint pain and the depression, even though it hasn't helped the anxiety. I just hope the bloating calms down, as I feel like it puts pressure on my heart."

• Chr...
• Taken for 2 to 5 years
• August 6, 2024

S-adenosylmethionine for Herbal Supplementation "I had been taking SAMe for years with virtually no side effects. I took 1 400 mg enteric-coated tablet in the morning on an empty stomach. I definitely felt a positive benefit from taking it, even at that low dose. Recently, I decided to stop taking it due to uncertainty about the long-term effects and, honestly, also about the cost. After a month or so after stopping, I noticed depressive symptoms returning, such as agitation, indecision, heaviness, etc. I am going to start taking it again, even though I still don't know about any long-term effects because, as anyone who has suffered from depression knows, relief from it is a real blessing."