S-adenosylmethionine and Gi Issues: What Users Say

• Nop...
• Taken for 1 to 2 years
• November 15, 2018

S-adenosylmethionine for Herbal Supplementation "Have used SAMe off and on to relieve osteoarthritis pain and to boost activity level secondary to depression. Had severe abdominal pain and nausea after taking one brand of SAMe. Had a similar issue with an OTC medicine to treat the GI disturbance. The common element was mannitol — a sugar alcohol that is present in some supplements and OTC medicines. Read online that this sugar alcohol can trigger severe GI disturbance in some people. I searched for and found a brand of SAMe without mannitol or any other sugar alcohols. There has been no recurrence of GI upset."

• Der...
• Taken for 1 to 2 years
• June 23, 2019

For Depression "Careful with this stuff, guys and gals. I believe it helped cure my depression. I took it for almost 2 years and only stopped cold turkey due to sudden severe GI discomfort. After I stopped, depression never returned, thank goodness. However, seemed to have kidney issues since started taking it. Now, about 5 years after stopping, having some significant kidney issues. I know this is common with several meds, but had no warning sign since it’s not FDA approved. Proceed with caution is all I say. God bless."

• Lyd...
• Taken for 1 to 2 years
• October 9, 2020

For Depression "Having suffered from anxiety and depression for almost two decades, I have been through a number of treatments. I had SAMe given to me by my naturopath to treat the severe anxiety. My dose is only 200g, and I always take it first thing in the morning on an empty stomach to avoid GI and sleep issues. I was instructed to take this for a few weeks every day until I felt my anxiety was gone, meaning my levels were up, and then to stop taking it until I thought my symptoms were starting to return. For me, that means one or two days in a row taking it, once or twice a month. It’s an expensive medication, so this works well for me. I have felt something akin to anxiety while taking it, like my mind moving faster than I could keep up with, but this is rare and generally a sign for me I’ve got enough in my system. Additionally, I take zinc and magnesium daily, and this combination has returned my quality of life, and I’m no longer on prescription medications."