Prometrium for Progesterone Insufficiency User Reviews

• Sta...
• Taken for 1 to 6 months
• July 21, 2019

"I was given Prometrium 100mg vaginal inserts for 14 days out of the month, along with Estradiol patch 1mg for post-menopausal symptoms. Prior to taking the Prometrium, I was sleeping poorly and had stubborn weight around the belly I couldn't get rid of. After menopause, my figure changed, and I gained a total of 10 lbs. Well, miraculously, in a month on these, I lost 7 of those pounds! I am sleeping really well, almost too much but maybe I needed it. My post-menopause pants are getting too loose now, and I think I'll have to unpack my high-rise jeans. Yay for Prometrium!"

• Jus...
• Taken for 1 to 6 months
• September 5, 2016

"I've been taking Prometrium for about 4 months now, and for the most part have no side effects. It works like it's supposed to and keeps my progesterone where it needs to be. However, just an FYI, you should always take it before bed with food. I mean lights out in bed to sleep, not watching TV or playing on your phone or tablet. If you take Prometrium and do not go to bed, it will cause a euphoric (high) feeling, which may be unsettling to some people and may cause panic because it does feel really weird."

• Anonymous
• March 20, 2010

"I'm pregnant and my lab work came back indicating I have a low progesterone level. My doctor prescribed Prometrium and initially I took the medication in the daytime, but then found that it makes me extremely tired. I decided to start taking the medicine at bedtime then started having very bizarre dreams only when I take the medication at bedtime. I informed my doctor, but he dismissed the side effect as not being related. I'm positive the side effect is from the medication. I hope this comment lets other women who experience this side effect know that you are not alone. Just because it's not a listed side effect doesn't mean it can't happen."

• skr...
• March 4, 2009

"I'm 48, and found that this nicely balanced the issues I'm having with estrogen dominance. I've had no side effects that I can tell, but a real clearing up of the fuzzy brain, night sweats, and trouble sleeping. I love it!"

• boo...
• November 22, 2016

"I was diagnosed with hyperplasia. I was experiencing very heavy, clotty periods for YEARS. I thought this was normal until I had a month-long period. This pill is heaven-sent. I have not had a period for about 8 months, have lost a ton of weight, have more energy than I have had in years, and I would say the only side effect is tender breasts. I cannot guarantee this result for everyone, but clearly I was not producing my own progesterone."

• Mia...
• Taken for less than 1 month
• June 18, 2021

"I am 46. I am estrogen dominant and have low progesterone. I also have PCOS. I take 100 mg after menstrual bleeding, 200 mg upon ovulation, and none when bleeding starts. My periods were abnormal (cycle 25-36). I take it by mouth at night and go straight to bed as it makes me extremely drowsy. If I try to stay up, I have lucid dreams. Some tiny stomach cramps but not bad. Breast tenderness has drastically decreased. Some left shoulder pain. Not sure if that has anything to do with the medication. Since starting break-through spotting during ovulation and a short window between ovulation and period. Cycle is currently now at 20 days. I have read this can happen but can’t find a lot of reviews on it. Not sure if that is normal and will be following up. Facial hair growth appears to have decreased."

• Jac...
• Taken for 1 to 6 months
• May 8, 2022

"Side effects not worth the gain. Had been using bioidentical progesterone (via a troche) for the last 12 years with no side effects, until my doctor retired, leaving a 5-month wait for a new bio-id doctor willing to take on new patients. In the interim, I moved to an online service that prescribed Prometrium. It's awful. I wake each morning feeling like I've been hit by a bus: deeply tired, no energy, no libido, and a consistently flat mood bordering on mild depression with swings of moodiness. The worst symptom, though, is the extreme increase in asthma and struggle to breathe even after the lightest exertion (something I've not experienced before and is equally frightening for my family). The service advised me to double the estrogel, hoping to balance it, then to cut the Prometrium dosage in half, but that's causing noticeable weight gain and the side effects lessen on the day after I don't take it, but not significantly. It's been 3 months of struggle. This drug clearly doesn't suit me."

• swh...
• Taken for less than 1 month
• October 23, 2012

"I am 49 and have been on this medication for one cycle. The side effects have not been as bad as I had anticipated. I had a few mild headaches, a bit of bloating, tender breasts, and a mild acne breakout, and was a bit tired a few days. I am taking it for a proliferative endometrium, and after 4 days being off the medicine, I am getting a period, so it seems to be working as planned. I am taking 200 mg."

• Anonymous
• October 19, 2011

"I am on a 100 mg dose, days 14-28 of my period or the first 12 weeks of pregnancy. The first month was great, I felt level. The only side effects felt were extreme sugar cravings and vivid, bizarre dreams. However, in month two, no cravings, extreme mood swings, and ranging from a need for a lot of sleep, not wanting to get out of bed, to anxiety and very little sleep. No pregnancy yet."

• Sat...
• Taken for 1 to 6 months
• April 22, 2024

"I am postmenopausal and take this product at night to help my symptoms and for sleep. For the first time in years, I've been getting 6 hours of continuous sleep and now feel nearly normal. Love it!"

• Anonymous
• December 31, 2008

"I experienced a few mild side effects - mainly mild nausea and irritability. Well worth the improvement in my overall health."