Pazopanib and Diarrhea: What Users Say (Page 2)

• Anonymous
• July 24, 2016

For Renal Cell Carcinoma "My husband started 800 mg Votrient 12 months ago, 3 months post-right renal nephrectomy with grade 4 renal cell carcinoma nodules in both lungs. CT scans 3 months later showed all nodules had shrunk, the last 3 CT scans have revealed no change, and he is stable. BUT he is suffering from massive bouts of diarrhea, as in some days/nights 10 or more times. He finds drinking the required amount of water makes him nauseous, but he looks dehydrated, pale, and is lethargic. Because of the urgent diarrhea, he is always worried about going places unless he knows where he can rush to the toilet, so he tends not to go far, so this really impacts his life. He also has vomiting at times. His specialist only says to take anti-diarrhea tablets and prescribed Maxalon."

• Kiw...
• Taken for 5 to 10 years
• March 9, 2021

Pazopanib for Renal Cell Carcinoma "Using Votrient from Jan 2013 until July 2020. Had right kidney removed in Nov 2011 on diagnosis of my cancer. Metastasized in my submandibular and parotid glands in Sept 2012, starting Votrient in Jan 2013. Side effects appear to improve over the years, the main issue was blood pressure and diarrhea. I stopped Votrient to try SRT, which appears to be working."

• Bin...
• Taken for 2 to 5 years
• November 30, 2016

For Renal Cell Carcinoma "I have stage 4 RCC. The drug worked for 4 years, the docs were surprised that it worked so long. I had most of the side effects: diarrhea, hair turning white, stomach cramps, but better than the pain. The tumors ate through a rib, 2 neck vertebrae, and my kidney, and some small ones in my lungs. The kidney and vertebrae were removed. The tumors doubled in size. I am now on Afinitor."

• Bob...
• Taken for 5 to 10 years
• July 2, 2024

For Renal Cell Carcinoma "I was diagnosed Christmas Eve 2007 with a stage 4 tumor on the right kidney. Had nephrectomy of the R kidney, adrenal gland, and a portion of the renal vein in Jan 08. A few months later had a tumor on the L adrenal gland removed. In 2014 RCC met on the left shoulder blade; had 1/3rd of the blade removed. In 2015 a scan showed 7 lesions of various sizes on the liver. Started on 800 mg daily of Votrient in March 2015. Overnight my hair went from dark brown to grey. This is the only side effect I have experienced. The tumors on the liver have gone from 7 to 2 in about 9 years. I do have fatigue, but it is due to a lack of adrenal glands and no hormones. I take synthetic meds for fatigue and replace some hormones. After 5 years, I started having severe diarrhea, so I take a combo of Imodium AD and a probiotic. It helps control it. I feel great as of today, but early on with RCC, had problems walking but could still function. Daily exercise is a must even when one does not feel up to it."

• Sou...
• Taken for 1 to 6 months
• January 26, 2022

For Renal Cell Carcinoma "My father-in-law (age 76) suffered from renal cell carcinoma. After nephrectomy of the affected kidney, he was fine with a single kidney for more than 1 year. His creatinine was around 1.1 to 1.2 (with a single kidney). He did not have any high blood pressure or diabetes. However, after a routine CT, a few questionable nodules were detected in the lungs. Without cross-verification (like repeat scan/biopsy/PET scan, etc.), his oncologist prescribed him pazopanib 800 mg per day. Soon after starting the medicine, his blood pressure became extremely high (200/100), and creatinine started jumping from 1.1, 1.8, 2.2, 2.8, 3.2, and 3.5 in 3 months. His platelet dropped from 165,000 to below 50,000 with a lot of side effects (vomiting, diarrhea, etc.). We repeatedly informed the oncologist, but he was in denial mode. When we consulted a nephrologist, he stopped the medicine. The deteriorating renal function stopped at creatinine 3.5. But, unfortunately, his platelet did not recover from below the 50,000 mark, and he died due to a cerebral hemorrhage."

• Sho...
• Taken for 1 to 2 years
• August 6, 2018

Pazopanib for Renal Cell Carcinoma "I've had a very good experience with this drug and have been on it since Nov 2016. Diarrhea has been a side effect, but a small price to pay to feel overall very good!"