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Systane and Headaches: What Users Say

Headaches: mentioned by 6 users (5.4%)

Based on user experiences from 112 Systane reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

blurred vision 26.8%
burning 17.0%
itching 14.3%
vision issues 9.8%
swelling 8.9%
headaches 5.4%
light sensitivity 5.4%
stinging 5.4%
dry eyes 4.5%
eye pain 4.5%

Reviews for Systane

Commonly mentioned side effects
  • Dal...
  • Taken for less than 1 month
  • August 23, 2020

For Dry Eye Disease "I have recently started using this to help with eye lubrication from mild dry eye. I have used Refresh in the past & recommended this too many patients over the years. This product (Systane) has made my eyes burn TERRIBLY! This has led to blurry vision & headache. I will not be using this & cannot in good conscience (based on my own & many others' experiences) recommend this to anyone else either."

1 / 10
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86 Report
  • wob...
  • Taken for 2 to 5 years
  • July 18, 2019

For Dry Eye Disease "I've been on these eye drops since 2014 when Hypo Tears went off the market. My dry eyes were never really helped by Systane, and I found out recently that they're a big cause of my frequent migraines. I didn't connect the Systane to my headaches until my mom mentioned she was getting bad headaches after using Systane. I stopped them for a few days, and the migraines dropped considerably. I've since switched to a no-name generic eye drop I found at Walmart and haven't had any issues at all with it. Wish I'd made the connection between the Systane and my migraines before now because it's been five long years of pain for me."

1 / 10
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69 Report
  • Adi...
  • Taken for less than 1 month
  • October 30, 2019

"I suffer from repetitive corneal erosion, used Systane drops and gel just before bed in my right eye only, as recommended by my optometrist. I started noticing I was getting headaches that required pain relief. What concerned me most was a throbbing down the side of my head. My eye sockets ached, vision became more blurred, and the floaters were far worse. I stopped the product after 3 days and will never use it again after reading the other reviews. I was interested to see that it caused migraines in other people."

1 / 10
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38 Report
  • Adi...
  • Taken for less than 1 month
  • October 30, 2019

"I suffer from repetitive corneal erosion, used Systane drops and gel just before bed in my right eye only, as recommended by my optometrist. I started noticing I was getting headaches that required pain relief. What concerned me most was a throbbing down the side of my head. My eye sockets ached, vision became more blurred, and the floaters were far worse. I stopped the product after 3 days and will never use it again after reading the other reviews. I was interested to see that it caused migraines in other people."

1 / 10
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38 Report
  • Pop...
  • Taken for 1 to 6 months
  • July 22, 2013

For Eye Redness "I have used Systane for about 9 weeks and have been experiencing severe swelling and irritation of my eyelids, including splitting of the skin and drying out of the sore areas. Have narrowed down the cause as Systane, and not blepharitis."

4 / 10
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45 Report
  • Asg...
  • Taken for less than 1 month
  • February 20, 2021

For Dry Eye Disease "I notice this week my eyes were dry, I placed 2 eye drops of Systane Ultra High Performing Dry Eye Relief in each of my eyes. Within minutes, the back right side of my head began to hurt and throb. I knew this eye drop caused the pain. I read about the main ingredient polyethylene glycol 400 0.4 can cause head pain."

1 / 10
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8 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.