L-methylfolate for Depression User Reviews (Page 4)

• Ros...
• Taken for 1 to 6 months
• August 14, 2018

"I’ve been on so many antidepressants. None made me feel great. Improved the depression for a while, then pooped out. Or the dose was raised, and I had no emotions at all. I started Enlyte. I’m in month 3. It’s subtle and gradual for me. But I’m napping less. Back to reading and doing artwork again. I feel much less of the 'ugh, this is too hard.' I’m putting one foot in front of the other on automatic instead of such a forced effort. Well worth the $30 a month. I don’t miss any work, as work is less of a drag, so it pays for itself. I’m living my life for the first time since I was a teenager. At age 60!"

• Lau...
• Taken for 1 to 6 months
• May 31, 2017

L-methylfolate "I started this supplement with high hopes. I was given it to boost the effectiveness of the Pristiq I'm taking. After using it for over a month, I'm disappointed. Really have experienced no change. I'll keep searching for the right combination of meds."

• See...
• Taken for less than 1 month
• December 16, 2017

L-methylfolate "MUST take Deplin and not a generic and definitely not over-the-counter folic acid or folate! These can make things worse! My C spinal fluid showed that I have a less prominent type of folate abnormality. Wasn't detected in a gene swab test. Anyway, just started taking 15 mg as an antidepressant add-on. Made my depression & anxiety worse!!! I would stop taking it, but my doc has me taking a lower dose as she recognizes that Deplin can cause a worsening of symptoms in certain folks. It just needs to be started low and gradually increased. So, please start with a low dose if it makes you MORE anxious/depressed at 15 mg. Too early to say it helps, but the lower dose is needed to start, for some. And it may take many months to work--for some!"

• Abl...
• Taken for less than 1 month
• April 27, 2018

"I've had depression for most of my life and have been suffering from premenstrual dysphoric disorder (PMDD) the last five. I was prescribed l-methylfolate by my psychiatrist to go along with my anti-depressants a year ago, but for some reason I didn't take them. If only I knew! I took those and noticed a difference right away, but when I ran out, my insurance wouldn't cover it (different insurance company at the time), so I had to go OTC. I have felt so much better since taking the MethylPro at 10mg. I am actually happy, content, and I laugh. My PMDD is calming down. I've only been on it about two weeks consistently. Yesterday, I woke up and exercised! I've been doing some type of exercise the past week almost every day: yoga, dance, kickboxing (not actual kickboxing, but as exercise). It's amazing how much energy I have, but it isn't that caffeine-driven energy feeling, if that makes sense. I haven't been tested for the gene mutation and am going to inquire about it when I speak with my doctor next."

• sky...
• Taken for less than 1 month
• June 5, 2017

L-methylfolate "Like many others, I took the Genomind test, which told me that SSRIs were not optimal and that SNRIs were a better choice. After 16 years and 20 different meds, I have had much better success with SSRIs than SNRIs. The test results also said that I was deficient in what Deplin could provide. I have been taking 15 mg of Deplin for almost 3 weeks now and have been experiencing some of the lowest depression that I have ever felt. Today, I woke up feeling just as miserable as I have been for the past 3 weeks, so I decided not to take Deplin. As I slumped through the morning, I started to feel a wave of happiness and excitement for life come over me around 10:30 am, and I still feel great. I feel like 'my' normal self again. $60 wasted!"

• Jon...
• Taken for 2 to 5 years
• February 26, 2020

L-methylfolate "I took this for a while at the recommendation of my psychiatrist. I have the double MTHFR mutation. It did nothing for me and is prohibitively expensive. I’m not sure if I buy into their MTHFR serotonin theory, but it seems to work for some. For me, I would get these weird sensations in my hands and feet, almost like they were heavier or more sensitive, and I felt like my sleep was less restful (even I got 8 hours consistently) because I was always tired. It made me feel off as well, but I assume that is just depression medication in general."

• Not...
• Taken for 1 to 6 months
• January 24, 2022

"I have a double mutation with the MTHFR situation. It took a long time to get my insurance to cover this. I take 15 mg twice a day, and just like all these other reviews, I am no longer dying. I see that a lot of people are taking 15 mg once a day, so I don't know why I'm on it twice a day, but I went from feeling like somebody who was literally being swallowed up by quicksand to somebody who is alive. I've been on it for 5 months. I have no side effects. It feels crazy to feel normal."

• Jon...
• Taken for less than 1 month
• May 14, 2019

"I have been struggling with depression and anxiety for 4 years. I used Trintellix, which helped me a lot with memory and anxiety, but I was extremely flat in emotions. I then started modafinil and got a huge improvement. Then I was changed to methylphenidate 20 mg ER, and the Trintellix was reduced to 10 mg. I was using a B vitamin combo that includes methyl folate and methylcobalamin. I suspected it made me anxious, but one of my friends told me that it gives extreme energy at high doses, so I started 10 mg methylfolate. On the first day, I was so happy in the morning, in the afternoon, I was extremely angry, yet felt powerful. A friend recommended that I should use niacin with it, so I added 500 mg niacin. Now I cry when I listen to music or read what I like. It gives a huge boost to methylphenidate, also, the anger went away when I added niacin. I feel emotions so deep and cry with happiness. I am not hyperactive anymore, but I have high energy levels. I can go to work, then to the gym after meeting with friends, and sleep like a baby. I hope this will not change in time."

• KTg...
• Taken for 6 months to 1 year
• November 15, 2017

"I started taking MethylPro after I was prescribed Deplin and could not afford the monthly cost once my insurance discontinued it. MethylPro has actually made me feel better than ever, I believe I was having a reaction to one of the additives in Deplin, and it was making my skin itch. I no longer have that issue, and I feel the effects more quickly on the MethylPro. It has allowed me to no longer be on antidepressants, and two months ago I started taking one with cofactors. I'm now training for a half marathon in March. Life is now fulfilling, and I'm full of energy, L-methylfolate has been a game changer for me!"

• max...
• August 20, 2010

"I am a 63-year-old man (a psychologist) who has had treatment-resistant depression for many years. In the past ten years, I also have had frequent (10-15/month) migraines-migraine and mood disorders often appear together. I started on Deplin 7.5 mg/day along with Zoloft 50 mg/day last month. I had been on Zoloft alone previously with no improvement. After 3-4 weeks of no change in mood or functioning, my psychiatrist increased the Deplin to 15 mg/day and the Zoloft to 75 mg/day (not a high dose). Within a few days, I experienced an increase in energy and a sharp decrease in depressed mood-to the point where I'm feeling back to what 'normal' was decades ago. I have been through numerous antidepressants and never experienced this."

• stg...
• Taken for less than 1 month
• February 4, 2015

L-methylfolate "I've been using antidepressants for quite a few years now. I seem to have gone through the entire list of antidepressants. My latest script is Escitalopram Tabs, 10 mg. We recently added Abilify and this Deplin Caps, 15 mg. I've been feeling a bit better. One of these two gives me an awful case of heartburn! Painful it is. I'll mention it during my next appointment. Now, as before, I can't watch anything with intense emotions as I'll break down and start crying. At age 52, I find it a bit annoying. Before I added these last two medicines, I found myself crying more frequently than not. The movie 'UP' really freaked me out. Anyway, I'm disabled with intractable pain. That's what started all the depression stuff."

• Bri...
• September 2, 2021

L-methylfolate "I was having major anxiety and insomnia stemming from shoulder surgery. I wasn’t sure what was wrong with me. I eventually found a psychiatrist, and he prescribed Klonopin. That made me more depressed. I decided I needed a better psychiatrist. After meeting with this doctor, he decided to do the genetic testing. Three days later, I found I have MTHFR. Compound heterozygous. I've been on Deplin 15 mg for over a year. I also take 10 mg Lexapro per day. Anxiety is better, and I’m not nearly as angry. Changed my life for the better. Better late than never. I’m 54."

• Joh...
• October 16, 2014

"I'm 47 and heterozygous for both MTHFR mutations. I just came out of a deep, dark depression with the help of Effexor. I started taking 0.5 milligrams of methyl folate (yes, a very low dose) about a month ago. Even this small amount of methyl folate (in combo with methyl B12) affects me deeply and immediately. I take it before 8 in the morning, and it still influences my sleep that night. I have never been an active dreamer, but on methyl folate, I dream A LOT. I seem to feel more awake and active in the afternoons as well. I agree with the commenter about being on methyl folate for a period of time before deciding if it works for you. You may feel the effects immediately, or later on. There may be ups and downs."

• Sno...
• Taken for less than 1 month
• May 7, 2019

"Tried Neurofolin today. As I was considering giving it to my late teen with low mood and energy, I thought I would be the guinea pig first. Had a positive experience. Felt focused and alert all day, with sustained results and improved mood and outlook. A little jittery, but personally managed okay with that."

• Lyn...
• Taken for 1 to 6 months
• September 18, 2022

L-methylfolate "I took Deplin during a former depressive episode, but in a much smaller dose. I cannot say if it helped with the effects of depression. During this episode, my doctor recommended taking 15 mg. I was taking Deplin for 3 months. I was having unbearable anxiety and began looking carefully at the side effects of my meds. Deplin can cause severe anxiety, along with other negative side effects. There is an article online called ‘Anxiety Nutrition Solutions’ by Trudy Scott with Dr. Benjamin Lynch. He is a major supporter of methyl folate. He talks in the article about the different side effects patients can experience on Deplin, severe anxiety among them. If you’re taking Deplin and are feeling anxiety, please read."

• Fin...
• Taken for 1 to 6 months
• February 1, 2020

"I've suffered from depression since my early thirties. At that, was when it was diagnosed. I've tried most of the antidepressants, and for short periods of time, they certainly have assisted me in coming out of some pretty dark places. Now, into my 50s, I'm tired of taking the medication and do not feel that it has been assisting me. Recently, I have tried Nurofolin, and I can't believe the difference. I weaned myself off the antidepressants and then began taking your folin. Within two weeks, my mood was lighter and my anxiety reduced considerably. I have now been taking it for well over three months. I would definitely recommend this for anyone who has done the work and now just wants something to keep their mood balanced. Of course, this is not for everyone, but in my experience, I am so grateful to finally find something that truly helps without the chemical side effects."

• Fox...
• May 1, 2017

"Wow, this stuff is amazing! It did not work at first, but my sister, who is a nurse, told me that because I had gastric bypass, I probably need to take more than the 15 mg because gastric bypass patients do not absorb nutrients very well at all and need supplements. I am now taking 45 mg per day without any side effects. And the negative thinking has all but disappeared. I had a DNA test done as my new psychiatric nurse practitioner, after having listened to my woes of having no success with meds or ECT, immediately insisted that I take the DNA test. As she suspected, I have not one but two mutations on my MTHFR gene, which decreases my ability to process folic acid in a big way. She suggested that I try Inositol/Choline too."

• Fru...
• December 6, 2019

"tl;dr: 5-MTHF, methyl folate calcium salt, whatever it's called by the manufacturer, some forms work better for some people than others. My depression responded poorly to nearly every antidepressant on the market for 10+ years. Turns out I'm homozygous for the MTHFR mutation. Started taking 1 mg L-methylfolate pills by Superior Source, increasing every few days to hit the recommended 15 mg/day for depression. Had an immediate improvement in energy, and my other meds, like Allegra, started working better. I also tried OptiFolate 7.5 mg, MD Life 5 mg, and NOW 5 mg. My depression symptoms and skin picking came back on each of those. My psychiatrist finally wrote me a prescription, and now I'm on 15 mg pills made by Breckenridge. They work as well for me as OptiFolate: not very well at all. YMMV (your mileage may vary), I've seen reviews on Amazon where people responded much better to OptiFolate than Superior Source. Do your research, and try different makers if one doesn't work for you. I'm waiting for a new prescription."

• Fre...
• Taken for 1 to 6 months
• August 27, 2022

L-methylfolate "I had been struggling with depression for many years. Had many bad experiences with the usual anti-depressants, SSRIs and such. After doing the gene psych test and finding out I was homozygous for the MTHFR gene, I asked my doctor if I could try Deplin, and he said yes. After just three days, it felt like my depression had mostly gone away. After three months, I continue to feel better still. This drug has really been a miracle for me. And I have experienced zero side effects from it. I take the 15 mg. I take it in combination with 7.5 mg of mirtazapine. I hope this helps somebody who is on the fence about taking Deplin. It is a little bit pricey, but for me, it has been worth every penny."

• kte...
• October 27, 2014

L-methylfolate "For the past several years, I have been trying to find the right balance to deal with the anxiety and depression of Post-Traumatic Stress Disorder. I have been on Citalopram for the depression, and that seems to work well. It has been hard to find an antipsychotic that works, and currently, I'm on Latuda. I'm also on a mood stabilizer, Lamictal. My doctor added Deplin. Long story, I wound up without my Latuda and Deplin for about 6 weeks. In 6 weeks, I was off the charts on the ups, and my old patterns were popping up. Not good. I went back on the Latuda and began evening out, but still had too much up. Now I've been back on the Deplin for a week, and I feel completely numb. Trouble sleeping at the right times, trouble being awake or at least alert at the right times."

• jon...
• November 12, 2016

L-methylfolate "I am taking 225 mg of Lamictal for depression. The Dr. wanted me to try this along with the Lamictal. I took it once, at bedtime, and woke up with the worst headache I've had in my entire life, and it lasted all day. Also had very loud ringing in my ears, which lasted all day. Not good. Needless to say, I did not take it again, so I cannot comment on its effectiveness."

• Ble...
• Taken for 1 to 2 years
• February 10, 2021

"Very good supplement for the treatment of depression. It's definitely good as an add-on to prescription antidepressants. Most people with mental health issues are lacking in folic acid, and l-methylfolate is the most potent kind of folate."

• Len...
• April 8, 2011

"I have battled depression and anxiety for 15 years and was prescribed Klonopin. Over the years, I have remained on Klonopin, in addition to Paxil, which was added 6 years ago. I didn't see any significant changes in my depression, but my anxiety was under control. After trying several antidepressants with no significant change in my depressive mood, I was frustrated. My doctor prescribed Methylfolate, and today is my 2nd day taking the medicine. I woke up this morning with hope, energy, and excitement. It has been years since I have felt excited about what a day in my life would unfold, and it happened today. I feel like I am participating in life today as opposed to being a spectator."

• Amy...
• Taken for 1 to 6 months
• October 2, 2022

"I thought Deplin was helping my depression at first, but soon realized that the severe anxiety and insomnia I was experiencing coincided with when I started taking it. Granted, I take other meds, but I had zero anxiety and practically no trouble sleeping before I added Deplin. It’s a shame because at first I thought it was helping me, but the side effects were intolerable."

• Sev...
• Taken for less than 1 month
• December 14, 2021

L-methylfolate "I was so hopeful hearing about the possibilities of Deplin and depression. I've tried twice, once at 15 mg for about a week, and had bad headaches. My doctor suggested taking half (7.5 mg) the dose to see if my body would adjust at a lower dose, and unfortunately, it hasn't. In the early start, though, my mood was better, and I was sleeping restfully while on it for a short time. The headaches are like migraine severity. They start in the neck, up the back of my head, and towards my ears. They last for a few days, during which I have to take Aleve just to be able to manage the pain. It would have been great to see if this would continue to improve my depression, but it's definitely not worth the painful side effects I experience."