L-methylfolate for Depression User Reviews (Page 3)

• KQa...
• Taken for 1 to 6 months
• May 5, 2021

L-methylfolate "My child has been on antidepressants for three years. I read about MTHFR gene mutations and felt this might be the case with my daughter. Her psychiatrist recommended a trial of Deplin rather than testing since Deplin would be the treatment. The results are nothing short of amazing. I have my daughter back!"

• Rav...
• Taken for less than 1 month
• January 5, 2020

"After 40 years of SSRIs and counseling failing, I felt hopeless. Many days were torture. I tired too easily, felt sad, hopeless, unmotivated, and anxious more than I should have most of my life. Finally, I took l-methyl folate at 15 mg and got an immediate rash. Then, based on internet info, I took 1 mg. I noticed an immediate reduction in sadness, improved energy, and interest...but by day 4, I had an unbelievable panic attack with dry heaving and misery. Thankfully, I knew to take niacin and, within the hour, I was normal. This happened 4 times, and I had had enough. But I was beyond despair, so I tried it again at between 0.25 and 0.5 mg and added a small amount of niacin (and will add methyl B12 because I think the problem occurred because I’m building up nitrous oxide). This tiny amount, taken carefully, has completely made me normal. NOTHING else did. I have the MTHFR gene mutation, severe form. To me, it’s like a miracle for which I waited too long."

• Anonymous
• April 30, 2011

L-methylfolate "I just took my second dose of Deplin. I love the fact that there are no side effects. I went all through the day without getting so angry at someone I would get an anxiety attack. It's a start and I'm hoping I can return to my normal self. Wish me luck."

• Hay...
• Taken for 1 to 6 months
• August 1, 2015

L-methylfolate "I started taking Deplin 2 months ago in addition to the 300 mg of Wellbutrin I had already been taking for several years. I was experiencing a very low level of chronic depression but generally okay. The doctor recommended I try Deplin to see whether it would increase my level of well-being. I could swear I feel a lot more depressed with the Deplin. Nothing has changed in terms of lifestyle over the past few months, so I can't think of any other explanation. Needless to say, I'm going to stop taking it. I had no idea it might worsen my symptoms."

• lad...
• May 2, 2014

"Wow. Where to even start? I've been on several cocktails of antidepressants from ages 13 to 28. Finally, my doctor prescribed methylfolate in conjunction with Celexa. Within 10 days, I felt more alive, motivated, energetic, and at peace than I had ever felt in my life. Absolutely a miracle. If you have given up on the endless trial and error, please, please give this a chance."

• whi...
• Taken for less than 1 month
• July 8, 2013

L-methylfolate "I have been taking Deplin for 18 days, and I do notice a slight change in my depression, brain fog, and energy levels. I think it is being inhibited by my Adderall withdrawal, but I am hoping it is helpful since I've tried many medications and nothing has really helped."

• Jen...
• Taken for less than 1 month
• August 4, 2014

L-methylfolate "I added Deplin 15 mg to a 150 mg dose of Wellbutrin when the Wellbutrin no longer worked as well. It did help for a few days, but then I developed severe muscle weakness, stiffness, and pain, particularly in my neck and shoulders. It was bad enough that I could not turn my head or look up or down without great discomfort. It kind of felt like I had whiplash. I did some research and found that the muscle pain can be a side effect of both medications. I have not ever had this problem on Wellbutrin alone, so I'm inclined to think the Deplin caused this. I quit taking both medications because I couldn't function with the pain and stiffness any longer, and two days later, the pain is still there but is slowly subsiding."

• chr...
• April 18, 2010

L-methylfolate "I hope this helps to all the depressed people out there. I have been seeing a psychiatrist for drug-induced depression. I abused meth, Vicodin, coke, and any other drug you can think of for years, and that has left me a basket case. I have tried many antidepressants, but I suffer too many adverse reactions to the stronger stuff. I am currently on 300mg Wellbutrin and 15 mg Deplin, and I have to say I feel GREAT! However, I had taken the Wellbutrin/Deplin combo in the past, and it stopped working for me after 6 months. The results with the antidepressants were a little funny because I went back to abusing Vicodin. Now I am clean of any drugs and just taking what is prescribed by my doctor, 300mg Wellbutrin and 15 mg Deplin."

• Hel...
• Taken for 5 to 10 years
• July 10, 2019

"I had been prescribed this by the same psychiatrist who gave me Wellbutrin. It was originally covered by my drug plan, and I wasn't sure it was working. But then my plan stopped covering it (because they said it was a 'vitamin'), and I ran out. That's when I found the fog of depression setting in deeply. Deplin is ridiculously overpriced for what it is, and many other manufacturers make l-methylfolate equivalents. I have switched to one of those. I use 15 mg tablets and cut them in half, so a bottle lasts for 180 days. This is much cheaper than Deplin (the generic costs about 40 cents a day, Deplin without a prescription plan is about 4 dollars a day). Honestly, I think the methylfolate helps me, and the generic is affordable, and it works!"

• jer...
• Taken for 1 to 6 months
• July 12, 2019

L-methylfolate "Have taken Paxil for years, had a poop out with the Paxil, so the doctor added Deplin 15 mg, that did not work, had lots of confusion, out-of-touch feelings. I cut the Deplin back to 7.5 mg, and in three days, it is doing the same thing as the 15 mg. I would assume if you had a folic deficiency, it would work. However, I must have enough, and this just overloads my system. Not for me, cannot get off of it fast enough."

• For...
• Taken for less than 1 month
• July 11, 2016

"Normally I only peruse these listings, but this time I thought I owed it to all my fellow readers to give a detailed review. I began taking 10 mg methylfolate around 10 days ago at the urging of my father, who, for obvious reasons, shares a very similar genetic predisposition toward depression and anxiety. The results? All I can say is wow. Within 1 day, I felt like my internal motor that had been idling along at a 5 out of 10 had been turned up to a 10 for the first time in a long time. I had more energy, clearer thoughts, a happier disposition, appetite, and libido returned full force. My only regret is not trying this stuff sooner. If it feels like nothing has ever really solved the problem before, please try this. It's a miracle."

• See...
• September 4, 2018

L-methylfolate "Update to my previous post: I've now been taking Deplin for close to a year. It serves as an add-on to my antidepressant meds. It hasn't been a magical booster to improve my severe, resistant depression as well as my horrible anxiety. However, over a year's time, Deplin has helped me feel just enough better to justify its cost. A very subtle improvement that is difficult to describe. I'm glad that I stuck with it; not at all noticeable until at least 9 or 10 months. And that time frame (for subtle change) isn't acceptable if you are miserable. But I was improving just enough with my other meds to allow me to continue taking Deplin-just in case it began making a difference ....whenever? Plus, my doctor told me it was good for my overall health, regardless if it touched the depression. This made it easier for me to continue taking it despite feeling no benefit for a long time."

• Mal...
• Taken for 1 to 2 years
• February 15, 2015

"Depression sufferer my whole life. On Deplin for the last year, and my lows vanished within the first week on 15 mg/day. It's all I'm taking, and the benefit is absolutely profound. Zero side effects. Most psychiatrists downplay the lack of studies, but it definitely works for me better than anything else I've tried. Good luck."

• Anx...
• Taken for 1 to 6 months
• October 12, 2018

"L-methylfolate is great. I spent the last 3 years with increasingly crippling anxiety, and it was starting to limit my ability to work and live. At the point of attempting anti-depressants. Luckily, I came across an article for an l-methylfolate product. Given it's just processed folate and B12, I gave it a try because the side effects are so limited. WOW. AMAZING. Within a week (15 mg per day), I had my life back. I still get anxious, but it's like all of a sudden it's not so bad. I can laugh, smile, and be happy. I'm a better husband and father. Anyone who is struggling with thoughts of low self-worth, anxiety, or depression, it is worth considering trialing this drug. I wouldn't say that if the side effects weren't so limited: it's just folate after all!"

• spr...
• December 15, 2010

L-methylfolate "I started taking Deplin yesterday and recently tapered myself off of Cymbalta and Wellbutrin. I still have the Cymbalta withdrawal 'brain zaps,' but have regained my crying reflex that I lose every time I get back on medication. I have been pregnant several times and needed to come off all medications for the duration. Today I had more natural energy than I've had in a long time. I had been taking Hydroxycut just to get myself moving and to the gym as I had reached my maximum weight of 188 last week. Now I don't feel like I need it anymore. My OCD is almost non-existent now. I can complete multiple tasks without spending an eternity detailing every aspect of a small task. This is how I feel after day 2, hopeful this will continue."

• Els...
• February 24, 2012

"I have suffered from depression for about 30 years, crippling depression with anxiety since 1992. I am 62. I have taken nearly every antidepressant, and none really worked. I read this forum about four months ago and decided to order 5-MTHF, 10 mg. After about three weeks, I realized I was coming up from the deep depression. I was taking 20 mg of Lexapro and cut that down to 10 mg a day. I am excited that this might be what I need, but will wait a while before foregoing with the Lexapro because I'm not ready to enter that deep depression if this doesn't work by itself. I am so excited even if I do have to continue the Lexapro. To feel like getting out of bed, doing normal things, and feeling good is great. I will post updates."

• JDm...
• Taken for 1 to 6 months
• January 12, 2015

"After years of depression and anxiety, I'd been on countless combinations of medicines. The past few years, severe health problems (open heart surgery at 37 and a bowel resection at 39, over 200 days in the hospital) have contributed to the lowest lows of my life. I've spent the vast majority of the past two years in pajamas. Everything felt overwhelming. Living a normal life again seemed impossible. I had absolutely no energy and believed I'd feel tired forever, which made me sad all the time. After adding Deplin to the Celexa I've been taking for years, I am amazed by the results. It's been like flipping a switch in my brain. The darkness has been flooded with light. I have the motivation to live life again. Deplin is nothing short of a miracle!"

• jus...
• March 26, 2014

L-methylfolate "I thought I would share my experience, as it may be helpful to others. I have been on this for over 2 years now... and depression-wise (which is what I'm basing my rating off of because that is what this rating is supposed to pertain to), it hasn't done anything for me at all. At least nothing at all that I have ever noticed. I have stayed on the medication because of the fact it does help bring down my homocysteine levels. I have a condition referred to as MTHFR. Basically, it's a liver enzyme condition that makes it so the body doesn't convert proteins/peptides very well. Common condition (1/10 Americans) but rarely tested for. The lab had to look up what to do for drawing blood and testing for it."

• Jin...
• Taken for 1 to 6 months
• August 23, 2023

L-methylfolate "I have a genetic mutation which lowers my body's ability to convert folic acid into its active form, but had never been prescribed Deplin for my bouts with depression and lifelong insomnia. This spring, my mood started to decline and my sleep was worse. At one point, I was taking three medications for sleep. I told my new psychiatrist about my old genetic test results regarding folic acid, and he thought I should try 15 mg of Deplin. Within two weeks, my sleep improved dramatically - I was able to discontinue a sleeping medication, and within 3-4 weeks, my mood also became much more stable and consistent. I've now been taking Deplin for almost six months and have been able to discontinue another sleep medication (I still take one for sleep). Although I still get short bouts of lower moods, they are nothing compared to what they were prior to Deplin. I tried at least five add-on antidepressants prior to Deplin with no results. I had no side effects, and it's very easy to take - a real lifesaver!"

• CK1...
• May 26, 2016

L-methylfolate "I have been on Deplin 15 mg for about 3.5 months. I have the mutation and was hopeful that this would help. I noticed no change whatsoever in my anxiety or depression. I also started having severe joint pain, and nothing had changed but adding Deplin. My doctor recommended that I stop the Deplin. I have been off for 3 days and continue to have joint pain. Would love to hear from others with a similar experience."

• Zar...
• Taken for less than 1 month
• March 1, 2018

L-methylfolate "I had the swab genetic test done. I lack the MTHFR gene that creates the enzyme that breaks down folic acid to folate. Without folate, depression is very likely. My doctor prescribed Deplin, as it would take 60 bottles of over-the-counter folate to equate to the convenient orange capsule. The first three weeks, my depression and anxiety got worse. My doctor wasn't helpful, but I kept taking it. I’m around week 5, and I am able to see my compulsive eating as not good for me, as I am morbidly obese. I don't feel overly happy, but more in control in a chaotic world and able to focus more. I'll chat with my doctor about getting off Lamictal once I've had a couple of months on Deplin. I am far less paranoid and explosive, but I have routine scary dreams being out of control. I can't put my finger on it, but I think I am better off with Deplin and apprehensive to go off it. This is not the placebo effect talking. I think I can lose weight and get off the bipolar meds. I pay $160 for a three-month supply."

• Pay...
• April 21, 2017

"As mentioned in other reviews, Deplin is designed to augment other medications to increase their efficacy. All Deplin is is L-methylfolate packaged as a prescription medication by drug manufacturers to make money on a supplement that is readily available for much less cost. If you are paying more than $30/month, check out other brands. It sells L-Methylfolate 15 mg, 30 capsules for $30. They also have 7.5 mg capsules. Methylpro is not a generic Deplin. Methylpro is L-methylfolate. Deplin is L-Methylfolate. No difference. Naturopaths and savvy doctors (not the medication-only white coats) have been using L-methylfolate years and years before it was packaged as an expensive prescription 'drug.' Do your homework, save money, and stick it to the man."

• Jul...
• October 24, 2019

"So, I've been on a litany of meds for 40 years. I have BPD1, major depressive disorder with psychotic features. I sometimes have delusions and hallucinations. Both suicidal and homicidal ideations. This has been utterly unbearable because no antidepressants or antipsychotics have ever helped me. The antidepressants cause me to feel suicidal. About a year ago, a doctor gave me Deplin. I take it when I need to, and it works. Just 3 days ago, I felt suicidal and was hearing the voices inside my head. Day 3 of Deplin, and I feel better again. I only use Deplin and nothing else. Yes, it's tough managing the other symptoms by myself, but they're nothing next to my depressive episodes. All I can say is that L-methylfolate is helping me. It is the only thing that has ever helped. There are some side effects like palpitations, insomnia, and some restlessness, but I don't care."

• sti...
• September 29, 2009

L-methylfolate "I have had a partial response to my antidepressant. I have had a hard time finding one as my chemistry responds unfavorably to many drugs. Deplin was advised by my doctor, who has actually participated in clinical trials. She had seen no adverse effects and thought it would work great for me. On the 3rd day, I felt like my old self for the first time in 1 year. Unfortunately, that night I had auditory hallucinations... first time in my life... and a very restless night. Went off and slept okay. Tried just doing folic acid and Vitamin B6 and had the same response, only worse. Didn't sleep the whole night. Both my psychiatrist and psychologist say I am the only person who they have ever seen have a negative reaction. Like I said, I felt great. Good luck."

• Cin...
• July 14, 2009

L-methylfolate "I've been on Deplin for 20 days now, along with Zoloft. I had great success with Cymbalta, but it messed badly with my blood pressure (going from 112/65 to 175/100), so I had to go off it. I was put on Zoloft as a stopgap, but have tried it in the past without much success, as with all the others. They say it can take 4-6 weeks before Deplin has its full effect. I'm still hopeful, but I do so wish I'd seen the overnight change like others."