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Sprix and Burning: What Users Say

Burning: mentioned by 24 users (42.1%)

Based on user experiences from 57 Sprix reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

burning 42.1%
bad taste 7.0%
headaches 7.0%
pain 7.0%
nausea 5.3%

Reviews for Sprix

Commonly mentioned side effects
  • Jes...
  • Taken for 2 to 5 years
  • April 16, 2019

For Pain "I hate taking this. I mean hate taking it. It burns your nose, it usually makes me feel sick for a couple of days. But it helps so much with pain, even instantly. I would rather deal with a burning nose and sore throat than my fibromyalgia pain, so I am grateful for this medication."

10 / 10
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19 Report
  • Anonymous
  • April 26, 2012

For Pain "Was getting severe migraines. Tried aspirin and Motrin. Both didn't work at all. I needed something stronger. My doctor then prescribed Sprix nasal spray. She told me to spray to the outer part of my nostrils and to only breathe through my mouth (do not breathe through my nose or sniff, otherwise you will feel a burning sensation like others I've read on here). I did exactly as she instructed and AMAZINGLY the migraine was gone in 5 minutes. And there was no burning sensation at all. I love Sprix. It's now my go-to medicine to relieve my migraine."

10 / 10
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33 Report
  • Red...
  • Taken for less than 1 month
  • May 2, 2019

For Pain "So my first dose was a quite uncomfortable burning sensation. Second dose was less burning. 3rd and 4th doses for the day barely any burning at all. This has taken my pain from an 8-10 down to a 1-2 on the pain scale. I've used this medicine to treat my chronic low back pain, myofascial pain syndrome, and chronic sciatica. The doctor has given me this to get me through until I can get to pain management. I'm already seeing fantastic results, I might just continue with this medication."

10 / 10
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18 Report

Frequently asked questions

  • Sjs...
  • Taken for 1 to 6 months
  • March 15, 2018

For Pain "Please read if you are taking Sprix for the first time: It is VERY important that you do NOT inhale like you would with a typical nasal spray. It will burn like CRAZY and is completely unnecessary. Also, point the tip in the direction of your outer nostril. If you do this, you should get crazy pain relief. This is from someone who's been on 180 max strength percs per month for quite a while after my anterior cervical discectomy and fusion (ACDF) of C-5 C6."

10 / 10
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17 Report
  • Pai...
  • Taken for 1 to 6 months
  • September 25, 2020

For Pain "I find Sprix to be helpful for migraine and neck pain. Make sure to read the instructions carefully. Should be sprayed to the side of inside the nostril and not inhaled; breathe through mouth a few minutes, and this reduces the burning. Can use the same bottle up to 24 hours; don't put in the fridge after using. Can apply every 6 to 8 hours. My doc didn't say whether to do one or both nostrils, so I tried one the first time, and it helped. The second migraine episode, the headache was worse, so I tried both nostrils, and it helped. I'm a woman, age 58, height 5'5" and weigh 145 lbs."

9 / 10
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11 Report

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  • Taw...
  • Taken for less than 1 month
  • May 10, 2019

For Pain "I was given this by my neurologist for migraines. I’m also an epileptic, so taking any new meds can cause my seizures to be worse. So it’s been sitting in my fridge for 3 weeks. 4 days ago, I had a really bad seizure, and with it came the horrible migraine. I took my first dose of Sprix, and I felt like I had just sprayed pepper spray up my nose! Omg!! It was like an instant panic attack from pain! Once the pain in my nose was gone (about 15 min), I noticed my migraine was almost completely gone. I had to talk myself into taking my second dose. But once I made it past the burn, my migraine was completely gone, so yes, the Sprix works great on migraines, it was amazing!! My issue is how healthy is this if it comes with that much pain.....?"

7 / 10
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  • Anonymous
  • October 13, 2011

For Pain "Worked very quickly on relieving menstrual migraine pain. Following the instructions on how to properly use the spray is a must. I didn't the first time and felt a burning sensation that lasted about 3 minutes. The second time, I cleared my nose, looked down, inserted the tip, and angled it away from the center of my nose. That time I didn't feel anything at all."

9 / 10
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17 Report
  • Ava...
  • Taken for less than 1 month
  • August 19, 2018

For Pain "I absolutely wish there was a formulation I could take for more than 5 days. If I could take this every day, I could probably go off of my narcotic pain meds. I will agree with many, the taste and burning can be hard, but it’s definitely worth it. At least for me."

10 / 10
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  • Dia...
  • Taken for less than 1 month
  • December 18, 2018

For Pain "I have not found that Sprix is very helpful for me. I felt no change in my pain relief. The burning that some have mentioned was not that bad to me. Don't sniff it in. That's not how you are supposed to take it. Make sure to watch the video, and it shows exactly how to do it!"

3 / 10
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8 Report
  • gor...
  • Taken for 5 to 10 years
  • November 4, 2020

For Pain "When I used Sprix to treat my migraines, I was quite shocked over the severe burning pain it caused in my nose. The burning was far worse than the migraine, and I could not keep using this without lidocaine nasal gel or spray. At the time I bought Sprix, I did not have any drug coverage from my health insurance. Shockingly, a 1-month prescription cost me over $500.00 U.S. dollars!! When I asked to be switched to generic oral Toral (Ketorolac) tablets, the same month's supply and dosage cost me about $20.00 U.S. dollars. Oral ketorolac worked equally effectively to the Sprix nasal spray in terms of analgesia, drug onset time, and duration. I have gastroparesis (stomach paralysis), which can delay oral meds from reaching my intestine, but found that the 20-40 minute onset helped. My bottom line is to avoid Sprix nasal spray as it is grossly overpriced, and it causes such severe burning pain in the nose that Sprix scares away the migraine."

7 / 10
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6 Report
  • Kit...
  • Taken for less than 1 month
  • November 9, 2019

For Pain "I was prescribed this medication by my pain management doctor. Unfortunately, the doctor didn't tell me how much to use, so I called my pharmacist and asked him. He said 1 spray per nostril, which is what I did. No pain relief. I did more research this morning and found that the dosage is weight-based. Over 50 kg means that I need 2 sprays per nostril. Yes, it does burn, but not for very long. I'd read all of the prescribing information that came with the medication, so I knew about the nose burn, which will go away after time. I've been dealing with migraine pain, especially after having lidocaine shots over my eyebrows. This knocked down the migraine pain to tolerable. Unfortunately, I can't find out how long this drug will stop my pain after I stop using it. I'm guessing that it must last for a while, or the dosage would be higher. Unfortunately, I started on a Friday night, so I'll have to wait until Monday to call the company to get answers for my questions."

3 / 10
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4 Report
  • Anonymous
  • February 22, 2020

For Pain "Awful nasal pain and caused a horrible headache. Nose burned so bad that my eyes watered, and my nose wouldn’t stop running. Will never use again. Prefer the Toradol injection much more over this! Didn’t even touch my joint pain."

1 / 10
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5 Report
  • Anonymous
  • October 20, 2011

For Pain "The inhaler process is very rough on the nose; burning sensation, bad taste, sore throat. But eventually, that goes away, and you are left with an analgesic good for very mild pain. My doctor prescribed it for occasional severe back pain, and it is not working for that."

4 / 10
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9 Report
  • Lis...
  • December 25, 2017

For Pain "This medication worked so well that I can tolerate the horrid burning of my nose that seemed to penetrate all through my head and into my ears. It is awful but does not compare to the pain of a migraine headache. I was completely shocked by the results, I can actually go about my life as opposed to being confined to my bed and dark room, dry heaving from the pain and light and smell sensitivity. Trust me, 5 minutes of burning brain is welcomed compared to the results of this medication."

9 / 10
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3 Report
  • Fri...
  • Taken for less than 1 month
  • September 1, 2018

For Pain "I had a superior hypogastric plexus block, aka a giant needle guided by x-ray through muscles and spine to numb some nerves for my chronic endometriosis pain. I was given SPRIX to help in my recovery from the injection, and it did nothing but make me nauseous. If it helped with the pain, I couldn't tell. I think Percocet would do better than this NSAID, SPRIX. Note: I've got a tolerance for strong meds, so it takes a lot of anything to help me when I have severe pain. I think it might help others, but isn't strong enough for me. My dosage was 15.75 mg spray in each nostril every 6-8 hours. The burn hurts bad, makes me cry, and sometimes makes me sneeze. After 1 day of usage with no relief, I'm calling my doctor for something else. FYI: On the other hand, this block I get does help my endometriosis pain after the recovery from the injection itself. If you happen to have chronic endo pain, I can recommend this shot."

1 / 10
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  • Sur...
  • Taken for less than 1 month
  • December 1, 2017

For Pain "I had major ankle surgery. This was one of the medications I was given. You have to keep it refrigerated, but when opened, it can be at room temperature. I want you to know my throat hurt so bad after surgery, too. I had a nerve block done also, so I waited till the next day to use this medication. I read about the burning, but didn't realize it was like someone placing burning coals in your nose. I was like, omg, omg, for about 5 minutes. Then all of a sudden, no pain, not even my throat was hurting anymore. After about 6 hours, I did it again, it did hurt, but not as bad as the first time. The only thing was when it was wearing off, I got a bad headache. Other than that, no problems. For someone in moderate to severe pain, I would recommend."

10 / 10
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  • lan...
  • Taken for less than 1 month
  • April 18, 2018

For Pain "I used Sprix today for a migraine that’s been going on for about 4 months. I hated it, I tilted my head down and did as it said, but still, my nose burned so bad. And after that, it dripped into my throat, which hurt even worse, I wanted to cry. This lasted for about 20 minutes, and it didn’t even bring me any migraine relief."

1 / 10
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  • spd...
  • Taken for 1 to 2 years
  • January 13, 2023

For Pain "I suffer from refractory migraines. Sprix is faster to use than my intramuscular injections of Ketorolac. I have hemiplegic migraines, so if I miss my window, the injection becomes impossible. Unfortunately, Sprix doesn't work as well or as quickly as the IM Ketorolac. It's about 70% as effective, and it takes about 30 minutes to kick in and 45-60 for the full effect of Sprix to work, versus 10 minutes for IM Ketorolac to work and 30-40 minutes for the full effect of the injection. For that reason, I still use my IM Ketorolac more than Sprix, but I do admit Sprix has saved me plenty of times, so it is a good medication. When using it, it is important to look down, hold your breath, and spray it toward the outer, lower nostril. Then pinch - don't inhale. Breathe through your mouth and keep pinching your nose for a while. You won't get burning or any other issues."

8 / 10
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  • Kan...
  • Taken for less than 1 month
  • July 8, 2018

For Pain "Sprix burns my nose horribly! Even if I don’t inhale it later after I sniff just a little, it burns every sinus cavity and makes my eyes water and burn. Then when I finally lay back down, it burns my throat for about 30 minutes. It feels like I’m shoving jalapeños up my nose and in my sinus cavities. As for the pain, it doesn’t help there either. Maybe this medicine is just not for me."

1 / 10
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3 Report
  • Old...
  • Taken for 1 to 6 months
  • August 12, 2019

For Pain "I started using it for my sciatica pain, and it helps tremendously! If it’s burning your nose off, reread the directions and try again. I’m grateful to have it."

8 / 10
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  • Anonymous
  • October 10, 2011

For Pain "I experienced burning in my nose. Lasted about 5 minutes or so. Not sure if I can stand that again."

3 / 10
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7 Report
  • Twi...
  • Taken for less than 1 month
  • January 19, 2020

For Pain "Burns my sinuses and gives me a wicked headache. Didn't even dull my pain."

1 / 10
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2 Report
  • Tom...
  • Taken for less than 1 month
  • July 24, 2020

For Pain "When you use the nasal spray, you have to point the tip to the side of your nose, not up. Still burns for a few seconds, but really helped my pain. Reduced it by 50 percent."

9 / 10
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0 Report
  • Saj...
  • August 28, 2019

For Pain "It burns so bad your nose. I can’t not take."

2 / 10
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1 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.