Enhertu and Nausea: What Users Say

• bem...
• Taken for 1 to 6 months
• June 13, 2023

For Breast Cancer, Metastatic "Had 2 treatments with Enhertu. The side effects were bad and did not go away for a long time: dizziness, jitteriness in the entire body, fatigue, weakness, diarrhea, sick stomach, felt unwell all over and inside the body. Never, never would have another treatment with Enhertu!!"

• Bet...
• Taken for 6 months to 1 year
• July 26, 2024

For Breast Cancer, Metastatic "I have received treatments for 6 months. My liver lesions have all but disappeared. All of my lymph nodes shrank or healed completely. Side effects have been minimal, especially compared to the weekly chemo I was receiving. I have pretty severe fatigue and mild to moderate nausea for 5-7 days, my blood counts have stayed stable. I'm honestly not sure of the dose, but I am going every 21 days and will continue it until it no longer works or side effects are unbearable."

• Mal...
• Taken for less than 1 month
• March 19, 2024

For Breast Cancer, Metastatic "I had a response/reaction during the first dose that required stopping infusion halfway through. Emergency team came. Received rescue medication and evaluation in the ER. Ruled out cardiac event. Went home okay. Side effects included: profound fatigue, nausea, dizziness, malaise, mouth and nose sores, persistent bad taste, indigestion. By day 12, felt better and was able to do short walks, light social activities, sewing, light gardening, etc. Side effects above persisted but less. Second infusion 21 days later. Received full dose but given at slower rate (over three hours). Tolerated well. Side effects so far (day 0-7) post-infusion are heavier. Extreme exhaustion. Difficult to be out of bed. Nausea, bad taste, indigestion. Vertigo, dizziness, malaise."

• Anonymous
• Taken for less than 1 month
• April 27, 2023

For Stomach Cancer "As a patient, I can't rate the efficacy of this medication because I have had only one round. After many rounds of chemotherapy using other medications, I can say that the side effects of this medication were much worse and enduring after one round. Severe diarrhea, debilitating fatigue, debilitating nausea, and stomach pain. Side effects began on day four and lasted until day 7. Will take half dose next round but will continue on the regimen as prescribed for now. One lousy week out of three is not acceptable to me. If the next round is as bad, I will cease using this medication. The oncologist stated that while I tolerated other regimens better than most, I tolerated Enhertu worse than most."

• Ano...
• Taken for 1 to 6 months
• April 3, 2025

For Breast Cancer, Metastatic "Had done #6 cycle and dosage had reduced to 80% after the 2nd infusion due to liver dysfunction. The side effects are bowel system haywire, nausea, constipation, diarrhea, skin rashes, body heat, hair loss, and so on. The side effects are not getting better after each cycle. So helpless!!!!"

• Ano...
• Taken for 1 to 6 months
• April 3, 2025

For Breast Cancer, Metastatic "Had done #6 cycle and dosage had reduced to 80% after the 2nd infusion due to liver dysfunction. The side effects are bowel system haywire, nausea, constipation, diarrhea, skin rashes, body heat, hair loss, and so on. The side effects are not getting better after each cycle. So helpless!!!!"

• Ano...
• Taken for 1 to 2 years
• April 19, 2025

For Breast Cancer, Metastatic "Have been on this for 16 months, and it is working on the cancer that traveled to the liver. At first, nausea regularly, but that has been virtually gone for 8 months. Fatigue is the big issue faced daily. Sometimes takes me down. Cancer markers have dropped from 250 to 45."

• gjr...
• Taken for 1 to 2 years
• February 6, 2025

For Non Small Cell Lung Cancer "I have stage 4a NSCLC, DX July 2023. Spread was in both lungs, mediastinal lymph nodes, and pleural fluid. Primary tumor was 9 cm. 1st line treatment failed, and I started Enhertu September 25, 2023. By December 2023, my masses and nodules were either no longer seen or reduced by approx 50%. By March 2024, all masses and nodules were no longer seen on scans. Side effects are minimal, with mild nausea on occasion. Biggest issue is fatigue on days 3-5 and loss of taste. Labs are stable, and echos are normal. Still receive infusions every 3 weeks."