Skip to main content

User Reviews for Migranal

Migranal has an average rating of 7.7 out of 10 from a total of 23 ratings on Drugs.com. 73% of reviewers reported a positive experience, while 18% reported a negative experience.

Condition Avg. Rating Reviews Compare
Migraine  
7.4
20 reviews 88 medications
Cluster Headaches  
9.3
3 reviews 36 medications
Summary of Migranal reviews 7.7 23 reviews

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Migranal

Anonymous · February 3, 2011

For Migraine: “I give it a 10 because I was about to jump off a bridge in order to break the 18 day migraine I had up until this morning. It took 3 days of Migranal but I am FINALLY through the pain. I tried two rounds of steriods, Maxalt up to 3x's/day for 2 weeks, and FINALLY this worked. Although I am cautiously optimistic, this is the longest I have gone in 18 days without the debilitating pain that became so severe I was willing to go to very extreme measures to get it to stop. Thank goodness my Neurologist thought of it.”

10 / 10
Was this helpful?YesNo
jaxncadensmommy · July 17, 2013

For Migraine: “I have been suffering from migraines for about 2 years now. I've tried a few different prescription pills and I've suffered from horrible side effects from each one. I was to the point where I felt almost hopeless because I couldn't do anything to relieve the pain when I would get migraines. My neurologist prescribed me Migrainal last month and I've had 3 horrible migraines since then. Each time I have used Migrainal within 30 minutes they are gone and I feel great and not defeated by the horrible migraine. I definitely would recommend and consider this a miracle!”

10 / 10
Was this helpful?YesNo
Anonymous · January 18, 2012

For Migraine: “I have been getting severe migraines for more than 25 years. 99% of the time they would result in a trip to the ER for a few injections - since I can't keep anything in my stomach, pills were not a solution. Suppositories to control the vomiting so that I could take pills only made me more miserable - in other ways - and offered little to no benefit. Last year my neurologist prescribed Migranal Nasal Spray. Wow. What a life changer! Within 30 minutes I am good to go with little to no remaining headache. There isn't even enough time for the vomiting to start. I really want to spread the word on this to other migraine sufferers. It has been an amazing solution for me.”

10 / 10
Was this helpful?YesNo
Anonymous · Taken for 1 to 2 years · September 24, 2012

For Migraine: “Taste in mouth, burning in throat, stuffy nose and nausea which all passed after an hour. Medication effective within 60-90 minutes. Very effective and less expensive than a trip to ER to receive DHE intravenously. TAKE A ZOFRAN!”

9 / 10
Was this helpful?YesNo
JLHelm · June 1, 2013

For Migraine: “This medication is a miracle for me! I have had migraines for 26 years and tried just about everything. My neurologist prescribed this in an attempt to get rid of a 3 week migraine. I took the spray as directed and within an hour I was headache free. I have no side effects, no bad taste, nothing. It is truly my miracle!”

10 / 10
Was this helpful?YesNo
owka4u · Taken for 10 years or more · March 26, 2014

For Migraine: “I have Celiac disease and one of the side effects are migraines that use to last 3 or days until I found DHE 45 which was 1st done by IV. After that I was prescribed the shots until the nasal spray came out. After 15 years of research on my own I have come to the conclusion that either Celiac or other allergens are the prime cause of migraines that last more then 24 hours and maybe those as well; for these conditions cause swelling in every cell in the body including the neurons. I hope this helps others who suffer from the debilitating pain caused by these episodes.”

10 / 10
Was this helpful?YesNo
MNWalsh · Taken for 6 months to 1 year · December 27, 2013

For Migraine: “My Doctor prescribed me Migranal earlier this year. I've had migraines since I was 6 and have never found anything that helps this much. I prefer the pill I can take over the spray. I've been to the ER before and they give me DHE (Migranal) in an I.V shot and it's magic. Look into this if you need help.”

8 / 10
Was this helpful?YesNo

Frequently asked questions

RobinR · February 21, 2012

For Migraine: “My neurologist prescribed the Migranal for me last year when I got into a 2 mth long migraine that was seeming to be impossible to break. I'm also on Nortryptiline and Atenolol as preventatives and the Migranal is for PRN usage. (as needed) As someone else said, this drug does seem to work the best if you use it at the first sign of migraine. If you wait until your migraine is fully set in, it doesn't seem to work all that well. The downside to the medicine is that is does leave a terrible taste in your mouth, your throat burns, and your nose gets stuffed up. But compared the to severe pain of a migraine, I guess it's worth it. The worst part about it though is the COST.”

Was this helpful?YesNo
michellerand2001 · April 5, 2008

For Migraine: “Works well to treat migraines but you really need to rest after taking. I get an unpleasant burning sensation in nose, sinuses and throat, but still worth taking. Also, the bottle is a pain in the butt to assemble - especially when you have a migraine. I have frequent severe migraines (about 4 times a week) and this medicine is helpful although my dr. said it should not be used more than twice a week. I am allergic to all the triptans, so this medicine has been a good alternative treatment.”

8 / 10
Was this helpful?YesNo
Don't do it · Taken for 5 to 10 years · November 28, 2016

For Migraine: “This drug DAMN near killed me.. took as prescribed with in minutes I was confused and lost consciousness.. ended up in the ED . Woke up the next day with my face swollen double its size and having no idea what happened to me... DO NOT TAKE THIS MEDICATION!!!”

1 / 10
Was this helpful?YesNo
ashubina · January 16, 2009

For Migraine: “I have migraines usually 3 to 5 times a week and my neurologist gave me this medicine. I am also taking propranolol and have not noted any side effects. I have found that for me it works best when taken at first signs of a migraine. If I take it when I already have a migraine it doesn't work. There is a little nausea afterward but a little food helps. It's a very effective treatment and no rebound headaches.”

9 / 10
Was this helpful?YesNo
MariaMMB · January 23, 2016

For Migraine: “I had chronic severe migraines almost daily for 25 years. Some things have sort of worked; most not. Botox made an enormous difference in my headaches. I have been using Migranal for breakthrough headaches and life is very much better. This year, Migranal, nor its generic (which are made by the same company??), are covered under my insurance. I have Medicare, and I receive Social Security Disability. The generic cost is more than my whole SSD check. MY neurologist and pharmacists are out of suggestions. They say maybe I can ask for Patient Assistance Coverage, which almost always is only given to people who already have some kind of drug coverage. Or maybe the doctor can give me samples. I am horrified.”

7 / 10
Was this helpful?YesNo
Mainah · February 20, 2020

For Migraine: “Triptans unfortunately stopped working for me so, I decided to try this. First time I took it cut down my migraine by about 50%. Second time cut it down about 90%! Even helped my neck pain. Slight break through pain but much better. I just hope it keeps working! Only side effects I’ve noticed are tiredness and bad taste. Much better than a migraine.”

8 / 10
Was this helpful?YesNo
Anna B · February 13, 2018

For Cluster Headaches: “I was told about this medicine from an older friend whom had horrible, debilitating migraines all her life and was light and sound sensitive. I would lock myself in a room and hope for it to pass. I was prescribed migranol. The active ingredient is actually a fungus. It has been around since ancient Roman times. (look it up..pretty interesting ) yes, the mark up is somewhere between 250%, the insurance pays $4,500 for 8 bottles. Yes, there is "No" generic and the company that makes it is from France. Yes, if you take it incorrectly, you will taste it in your mouth and swallow it. Please read the instructions all the way!!! Take in the first 5 minutes of a migraine..it will be less effective if it's a full blown migraine. Takes my migraine away about 75%. No high(unless mixed with other drugs), no drowsy or lingering effects. I will continue to take unless my insurance says no more. Important stick to the dose and don't go over as the toxic effects are dangerous - but its not toxic at correct dose.”

9 / 10
Was this helpful?YesNo
Laurel Kaufman · October 8, 2019

For Migraine: “This is my first dose of Migranal. I just went to a new neurologist this morning and he gave me a sample. I have a slightly funny taste in my mouth but I think it's because my nose is stuffed from the Migranal. No signs of the horrible migraine monster yet, and the first signs of it have stopped. I get debilitatingly severe migraine headaches with panic/anxiety attacks. Triptans have not been reliable and I cannot afford to pay for a trip to the ER that many times a week. So far so good, nausea and stuffy, but that's a vacation to one of my headaches!”

9 / 10
Was this helpful?YesNo
sherrylblake · September 3, 2009

For Migraine: “Migranal Nasal Spray seems to have helped the migraine (within the 24 hours, not quickly). However, the muscle pain was tremendous for 48 hours following taking the 1st & 2nd doses. I changed from Triptans because of the muscle pain, but the pain with the Migranal is worse. I will try it one more time, but if the after effect (excruciating muscle pain, especially in my legs and feet) are as bad as my first experience, I will stop.”

6 / 10
Was this helpful?YesNo
Brandysanders · July 4, 2014

For Cluster Headaches: “I have suffered with clusters for the last 20 years. Every time I've been prescribed something that works, the FDA finds a negative reason to stop production. Migranal seems to work really well, but the price is ridiculous!! My pharmacist requests that I only get it at the end of the month due to his cost. Now my insurance cost on it is being raised. Go figure.....”

9 / 10
Was this helpful?YesNo
Joe with no migraines · December 9, 2017

For Migraine: “Migranal works for me 100% of the time, although somewhat slow acting (1-3 hours). I used to get migraines about once a week, with duration of 1-3 days, sometimes severe. For the past 3 years, I have been taking 10 mg of amitriptyline at night, and 37.5/25 mg triamterene/HCTZ in the morning. Under this program, I get the beginning of a migraine about once every 1-3 months, and these events have been 100% controlled by Migranal. Btw, the addition of triamterene/HCTZ was for Meniere's syndrome, and the effect on migraine was a positive, unexpected side effect (amitriptylene alone had reduced the migraines to about 1-2 per month).”

10 / 10
Was this helpful?YesNo
Mollie_T · February 1, 2009

For Migraine: “My neurologist gave me a sample of this spray during my last office visit. We're going the non-Triptan route trying to manage my migraines since I previously had a reaction to Triptans. This spray did nothing for my latest migraine at all. In it's defense my migraines are pretty severe and even hard core narcotics aren't much of a match for them. The search continues.”

1 / 10
Was this helpful?YesNo
PMM · July 31, 2009

For Migraine: “I get very frequent migraines, up to 15 per month. Have tried just about everything, including narcotics to control migraines. I am currently on Inderall daily as preventative (have tried many, many, other drugs as well). Am currently taking Maxalt and Treximet, but doctor suggested we try the nasal spray. I had a full blown migraine when I tried it, so results may be a little off. Migranal caused burning in the nose, and throat, nasal congestion. It also left a nasty taste in my mouth. Woke up the next day with the migraine still lingering.”

3 / 10
Was this helpful?YesNo
Laura · Taken for less than 1 month · February 12, 2022

For Migraine: “My daughter gets migraines that last 1-2 weeks. After years of misery and nothing working, I finally convinced her neurologist to let us try this. I read all reviews so had her take a zofran first. I gave her one pump in each nostril, waited an hour and did one more on each side. Within 30 mins the migraine was gone! We were on day 7 of misery. I am so happy this works and can be used at home. She had received this once before after being admitted to the hospital for a 3 week status migraine. It was previously an infusion. I had no idea we could get this drug for at home use. This drug is very expensive to buy but I did find a coupon. For 8 doses I was willing to do it just to end our misery. If you haven’t had luck with triptans give this a try. It’s a miracle drug!!! The only side effect was a bad taste in her mouth. No nausea but I did have her take the zofran 20 mins before I used the spray.”

10 / 10
Was this helpful?YesNo
Anonymous · Taken for less than 1 month · July 19, 2012

For Cluster Headaches: “I have suffered from cluster headaches for 7 years. My doctors have tried it all on me then one day I was administered this. A God send after so many years of pain and emotional turmoil.”

10 / 10
Was this helpful?YesNo
Migrainaloid · September 15, 2017

For Migraine: “Took the nasal spray version. It doesn't seem to do anything. My migraines continued at the same frequency and intensity.”

1 / 10
Was this helpful?YesNo

This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.