Denosumab for Hypercalcemia of Malignancy User Reviews

• AW ...
• December 17, 2016

Denosumab "I have lung cancer with mets to bone. Two hours after the injection, I experienced the worst pain ever in my life! I walked into the infusion area without any body pain, just a very slight backache which Advil was helping, and 2 hours later I was crippled. It's 2 weeks now, and I'm either in a wheelchair or walking around the house with a cane. Horrible, horrible medication. I now take oxycontin every 12 hours and oxycodone every 3 hours. Refuse this drug if you are smart. Even my oncologist is 'surprised' with the side effects I have. I refuse to have a second injection of Xgeva."

• jds...
• April 29, 2015

"I began a monthly regimen of Xgeva injections in January 2015. After the third month, I found out I needed dental work. My oral surgeon told me that the work I needed done was extremely risky while on this medicine because denosumab prevents the bone from rebuilding itself. If they had to pull my tooth, there was a chance that the hole left would never heal, and my doctor said that that situation would be 10 times worse than my cancer. The really shocking thing is that getting off this medicine for a month or two before a dental procedure is almost pointless because it stays in your system for up to 15 years! I don't know anyone who can go 15 years without ever needing dental work. Also, if I break a bone, it would never heal."

• mmc...
• June 20, 2016

"After breast cancer, I had to go on Prolia to counteract the possible fractures caused by my cancer meds. My PCP noticed my PTH levels were off the charts and sent me for a CT scan. My numbers went down after 5 months post-Prolia. They went up pre-2nd shot of Prolia. I went to the Mayo Clinic because I needed an answer. The endocrinologists there stated point-blank that the high PTH is common with Prolia, but that Prolia outweighs the possible fractures weak bones can cause. So I'm damned if I do, damned if I don't. He told me to up my calcium and take 1000 units of vitamin D daily."

• Ano...
• Taken for less than 1 month
• July 10, 2025

Denosumab "During routine monitoring by the oncologist, moderate hypercalcemia was noted (no known active bone mets). The doctor proposed a quick injection to correct it, failing to explain that it is a monoclonal antibody product (Xgeva), as I would never have consented to it. I strongly encourage everyone to read the composition of the medication and side effects list before accepting to be injected. Seventy-two hours after the injection, I was feeling as if I was going to die: general malaise, nausea, weakness to the point of inability to move. This prompted an ER visit. Strangely enough, apart from a sudden drop in phosphorus by 60% in 4 days, the blood test revealed no major issues. I still continue to feel dreadful, though getting a bit better 10 days after the injection. Doctors did not give me any answers…"