Skip to main content

Onexton and Dryness: What Users Say

Dryness: mentioned by 10 users (30.3%)

Based on user experiences from 33 Onexton reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

dryness 30.3%
peeling 15.2%
burning 12.1%
dry skin 12.1%
acne 9.1%

Reviews for Onexton

Commonly mentioned side effects
  • Anonymous
  • August 26, 2015

For Acne "I am 22 years old. I was given a sample of Onexton from my dermatologist so I could get started until I got mine mailed to me. Let me just say this stuff is AMAZING! My breakouts were significantly smaller and less noticeable with the first application. After a week, my face was close to completely clear, to where I just used it about twice a week. The reason I'm giving it a 9 and not a 10 is because it did dry me out a bit, but nothing you can't control with a good moisturizer. Overall, in LOVE with this stuff."

9 / 10
Was this helpful?YesNo
11 Report
  • esa...
  • Taken for 6 months to 1 year
  • February 14, 2019

For Acne "This stuff is the BEST! I have suffered with acne for years. Really painful under-the-skin cystic acne that has literally brought me to near tears, it hurt so bad. I tried everything, and nothing ever worked. This was the last option I had to try before my dermatologist went forward with cortisone shots and Accutane as a last resort. I have been using Onexton once a day for 6 months now, and I haven't had a cystic pimple in about 5 months! Or any pimple for that matter, besides the one occasional tiny pimple that you can't see, and hardly anything comes out. Gone by morning with Onexton! My skin is so clear and smooth, I love it. The only 2 downsides are the first month, it made me break out a little more than usual as it was trying to get rid of the acne rather than maintain a clear face like now. The other downside is it does make you dry, but as long as you exfoliate once or twice a month and use a good moisturizer, you should be square. I am so happy my dermatologist had me try this!"

10 / 10
Was this helpful?YesNo
7 Report
  • sun...
  • Taken for 2 to 5 years
  • February 7, 2020

For Acne "I've been using Onexton on my acne for 4 years with success. I use it before I go to bed at night and also wear it under my makeup during the day (it's better than generic because it doesn't cake). I used to get horrible, painful cystic acne before I started it. I'm 95% clear now with an occasional spot or two around my period. The overall texture of my face looks way smoother too. Despite some reviews, I do not find it drying at all. (I also apply prescription tretinoin every couple of days, which does dry me out). My confidence has gone way up since starting Onexton."

9 / 10
Was this helpful?YesNo
6 Report
  • Nik...
  • Taken for less than 1 month
  • August 16, 2019

For Acne "I have suffered from moderate acne after going off birth control, which messed up my hormonal balance. I have tried countless over-the-counter creams/masks, including retinoid treatments that cause severe dryness with eczema patches. This is the only medication that doesn’t cause any noticeable side effects with noticeable results within a week! The number one complaint I see is dryness, which can be completely solved by applying a generous amount of cream like CeraVe right after application."

9 / 10
Was this helpful?YesNo
7 Report
  • hay...
  • November 12, 2015

For Acne "I am 22 years old, and in the last couple of years, my skin has gone through some changes. I have oily/combo skin and acne-prone. I went to the dermatologist hoping for a simple fix product, as I was only trying to control small breakouts. I did not go in with terrible acne, maybe like 3 active pimples. He prescribed Onexton and Epiduo. Told me to use Epiduo at night and Onexton during the day. I had to stop using Epiduo after one week because it was so terribly drying, it was changing my skin color. I continued Onexton, and my skin got so much WORSE. I continued using for 3 weeks and decided to stop because my breakouts were out of control. I've never had skin this bad before. Switching to an all-natural routine. Fingers crossed."

1 / 10
Was this helpful?YesNo
13 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
  • JIL...
  • Taken for less than 1 month
  • July 18, 2015

For Acne "I have been dealing with adult acne for years. The product does work, but I had to give it a little time. It's been close to a month, and my skin is almost clear. I did have a few breakouts last week, but they were gone 2 days later. I also experienced some dryness and peeling after washing my face with Proactiv and applying Onexton right after. The other thing I noticed was unbearable stomach and leg cramps the first day of my period. I usually get cramps, but 1 Tylenol normally does the trick; not this time. My cheeks are a little rosier than normal, and my chin, which is where I apply most of the medicine, is turning a bit yellow (weird). I think it's worth a shot, but get in tune with your body in case there are any side effects."

9 / 10
Was this helpful?YesNo
11 Report
  • Chr...
  • Taken for less than 1 month
  • May 21, 2018

For Acne "I had been suddenly breaking out like crazy. Some huge cystic bumps and everything. I was using Aczone, and it worked pretty well in the past, but wasn't really helping with this. I was waking up with new bumps every day even with the Aczone on overnight. I started Onexton, and it's been about 2 weeks now. I have not had one new zit appear since starting this medication. All the pimples I had are gone. So, I'd say this has been a miracle for me. The only negative is it can be drying. That seems to be subsiding, and a good moisturizer helps."

9 / 10
Was this helpful?YesNo
6 Report
  • ED1...
  • August 9, 2017

For Acne "I have never had a problem with acne until I got into college. I am 20 years old, and my acne got so out of control I would never be seen leaving the house without tons of makeup covering my blemishes. I tried almost every over-the-counter acne treatment on the market and didn't notice any difference. Some of them would make a few pimples go away, and I would just get them back a couple of days later. I went to the dermatologist, and she prescribed me Onexton. This stuff is a miracle! After only using it for one night, I already noticed a significant difference in my face. I've been using it for a week now, and my face is almost 100% flawless. It will make your face dry, so make sure to keep moisturizing."

10 / 10
Was this helpful?YesNo
5 Report
  • She...
  • Taken for 1 to 6 months
  • June 7, 2019

For Acne "I love this product, Onexton. Disclaimer: it can cause dryness, so I apply a facial moisturizer first for sensitive skin. I’ve struggled with acne since puberty, and I am now 27 and have clear skin. I’ve tried so many products throughout the years, and this one works so well. I got a retail coupon with my derm, so it costs $65, but you only need to apply a small amount of gel, and it goes so far. I would definitely recommend this medication."

8 / 10
Was this helpful?YesNo
3 Report
  • kay...
  • August 3, 2019

For Acne "My skin has been bad for a few years ever since I started puberty. I went to the dermatologist and got prescribed this medication, and it worked wonders for my skin. After only a week of using it, I found that my forehead and chin became way smoother. It can cause some dryness, but it's definitely worth it. After insurance, I believe it was around $20. I definitely recommend this product for stubborn acne like mine."

9 / 10
Was this helpful?YesNo
0 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.