Generic Name: ziconotide (zye-KOE-noe-tide)
Brand Name: Prialt
Treatment with ziconotide may cause severe psychiatric and neurological problems. Patients with a history of psychosis should not receive ziconotide. You will be monitored often for evidence of thinking problems, hallucinations, or changes in mood or consciousness. If these symptoms occur, ziconotide can be stopped without causing withdrawal effects.
Ziconotide is used for:
Managing severe chronic pain in patients who cannot take medicine by mouth or do not respond well to other treatments.
Ziconotide is an N-type calcium channel blocker. It works by targeting and blocking N-type calcium channels on nerves that transmit pain signals.
Do NOT use ziconotide if:
- you are allergic to any ingredient in ziconotide
- you have a history of psychosis
- you have an infection at the injection site or a damaged spinal canal that interferes with circulation of cerebral spinal fluid
- you have a bleeding disorder
Contact your doctor or health care provider right away if any of these apply to you.
Before using ziconotide:
Some medical conditions may interact with ziconotide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, plan to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have or have a history of depression or have ever considered suicide
- if you have kidney problems
Some MEDICINES MAY INTERACT with ziconotide. However, no specific interactions with ziconotide are known at this time.
This may not be a complete list of all interactions that may occur. Ask your health care provider if ziconotide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use ziconotide:
Use ziconotide as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Ziconotide is usually administered as an injection at your doctor's office, hospital, or clinic. Ask your doctor if you have any questions about ziconotide.
- If you miss a dose of ziconotide, contact your doctor immediately.
Ask your health care provider any questions you may have about how to use ziconotide.
Important safety information:
- Ziconotide may cause drowsiness, dizziness, or decreased alertness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to ziconotide. Using ziconotide alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
- Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking ziconotide. Ziconotide will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
- Ziconotide is not an opiate and cannot prevent or reduce symptoms of opiate withdrawal. Talk with your doctor about withdrawal from opiate treatment.
- LAB TESTS, including kidney function tests, may be performed to monitor your progress. Be sure to keep all doctor and lab appointments.
- Ziconotide is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using ziconotide during pregnancy. It is unknown if ziconotide is excreted in breast milk. Do not breast-feed while using ziconotide.
Possible side effects of ziconotide:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Abnormal walking; back pain; bad taste in mouth; burning, aching, tingling sensation on the skin; constipation; diarrhea; dizziness; dry skin; feeling of a whirling motion; incoordination; increased cough; loss of appetite; muscle tension; pain; pain at insertion site; rapid, jerky eye movements; ringing in the ears; runny nose; skin irritation; sleepiness; sore throat; stomach pain; sweating; vision changes.
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal thinking; anxiety; change in mental state (eg, lack of energy, confusion, disorientation); change in mood or perception (eg, hallucinations; unusual sensations in the mouth; paranoia; hostility; delirium; manic reactions; psychosis); chest pain; dark urine; depression; fainting; fever; flu-like symptoms; headache; inability to empty the bladder; memory problems or memory loss; muscle cramps; muscle or joint pain; nausea; nervousness; pounding in the chest; seizures; speech problems; stiff neck; stupor; suicidal thoughts or behaviors; unresponsiveness; urination problems; vomiting; weakness.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; dizziness; drowsiness; garbled speech; loss of coordination; muscle twitching; nausea; rapid eye movement; stupor; unresponsiveness.Proper storage of ziconotide:
Store ziconotide as directed on the prescription label. Keep ziconotide out of the reach of children and away from pets.
- If you have any questions about ziconotide, please talk with your doctor, pharmacist, or other health care provider.
- Ziconotide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take ziconotide or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about ziconotide. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to ziconotide. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using ziconotide.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about ziconotide
- Other brands: Prialt