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Generic Name: carbetapentane/guaifenesin (kar-bay-ta-PEN-tane/gwye-FEN-e-sin)
Brand Name: Tusso-ZMR

Tusso-ZMR is used for:

Relieving unproductive cough and reducing mucus in the chest due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Tusso-ZMR is a cough suppressant and expectorant combination. The cough suppressant works in the brain to help decrease the cough reflex. The expectorant works by thinning mucus (phlegm) in the lungs, making it less sticky and easier to cough up. This makes coughs more productive.

Do NOT use Tusso-ZMR if:

  • you are allergic to any ingredient in Tusso-ZMR
  • you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days
  • you have severe high blood pressure, severe blood vessel problems, or an overactive thyroid

Contact your doctor or health care provider right away if any of these apply to you.

Before using Tusso-ZMR:

Some medical conditions may interact with Tusso-ZMR. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have chronic cough due to smoking, asthma, chronic bronchitis, or emphysema, or if your cough produces large amounts of mucus
  • if you have a history of heart problems, high blood pressure, prostate problems, an overactive thyroid, diabetes, or glaucoma

Some MEDICINES MAY INTERACT with Tusso-ZMR. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Beta blockers (eg, propranolol) or MAOIs (eg, phenelzine) because they may increase the risk of Tusso-ZMR's side effects
  • Mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Tusso-ZMR

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tusso-ZMR may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tusso-ZMR:

Use Tusso-ZMR as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Tusso-ZMR by mouth with food, water, or milk to reduce the risk of stomach irritation.
  • Drinking extra fluids while you are taking Tusso-ZMR is recommended. Check with your doctor for instructions.
  • If you miss a dose of Tusso-ZMR and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Tusso-ZMR.

Important safety information:

  • Tusso-ZMR may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Tusso-ZMR with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Tusso-ZMR; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • This product may contain tartrazine dye (FD&C Yellow No. 5). This may cause an allergic reaction in some patients. If you have ever had an allergic reaction to tartrazine, ask your pharmacist if your product has tartrazine in it.
  • Do not use Tusso-ZMR for a cough with a lot of mucus. Do not use it for a long-term cough (eg, caused by asthma, emphysema, smoking). However, you may use it for these conditions if your doctor tells you to.
  • If cough persists for more than 1 week or is accompanied by a fever, rash, or persistent headache, contact your health care provider. A persistent cough could be a sign of a more serious condition.
  • Do NOT take more than the recommended dose without checking with your doctor.
  • Tusso-ZMR may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Tusso-ZMR.
  • Tusso-ZMR should not be used in CHILDREN younger than 6 years of age; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tusso-ZMR while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking Tusso-ZMR.

Possible side effects of Tusso-ZMR:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Drowsiness; dry mouth, nose, or throat; headache; lightheadedness; nausea; upset stomach; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe or persistent headache or drowsiness; severe or persistent stomach pain or cramps.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include restlessness; seizures; severe agitation.

Proper storage of Tusso-ZMR:

Store Tusso-ZMR at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tusso-ZMR out of the reach of children and away from pets.

General information:

  • If you have any questions about Tusso-ZMR, please talk with your doctor, pharmacist, or other health care provider.
  • Tusso-ZMR is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Tusso-ZMR or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Tusso-ZMR. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Tusso-ZMR. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Tusso-ZMR.

Issue Date: June 3, 2015

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.