Generic Name: Nilotinib (nye LOE ti nib)
Brand Name: Tasigna
- This medicine may cause a prolonged QT interval (a type of heartbeat that is not normal). If this happens, the chance of other unsafe and sometimes deadly abnormal heartbeats may be raised. Sudden deaths have happened in people taking Tasigna (nilotinib). Do not take this medicine if you have low potassium or magnesium levels or a history of long QT on ECG. Your heartbeat will be watched often with an ECG. Talk with your doctor.
- Do not take Tasigna if you are taking certain other drugs, including any drugs that can raise the chance of a prolonged QT interval (a type of heartbeat that is not normal). There are many drugs that interact with this medicine. Talk with your doctor and pharmacist to make sure it is safe to take Tasigna with all of your drugs.
- Take this medicine on an empty stomach. Take 1 hour before or 2 hours after meals.
Uses of Tasigna:
- It is used to treat leukemia.
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Tasigna?
- If you have an allergy to nilotinib or any other part of Tasigna.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you cannot have galactose or you have lactase deficiency, lactose intolerance, or glucose-galactose malabsorption.
- If you are taking any of these drugs: Carbamazepine, dexamethasone, dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, phenobarbital, phenytoin, rabeprazole, rifabutin, rifampin, rifapentine, or St John's wort.
- If you are breast-feeding. Do not breast-feed while you take this medicine.
This is not a list of all drugs or health problems that interact with Tasigna.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Tasigna?
- Tell all of your health care providers that you take Tasigna. This includes your doctors, nurses, pharmacists, and dentists.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- If you have upset stomach, throwing up, loose stools (diarrhea), or are not hungry, talk with your doctor. There may be ways to lower these side effects.
- Blood clots have happened with this medicine. Sometimes, blood clots like heart attack and stroke have happened. Talk with the doctor.
- Patients with cancer who take Tasigna may be at a greater risk of getting a bad health problem called tumor lysis syndrome (TLS). Sometimes, this has been deadly. Call your doctor right away if you have a fast heartbeat or a heartbeat that does not feel normal; any passing out; trouble passing urine; muscle weakness or cramps; upset stomach, throwing up, loose stools, or not able to eat; or feel sluggish.
- Liver problems have happened. Call your doctor right away if you get signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- If you have high blood sugar (diabetes), talk with your doctor. This medicine may raise blood sugar.
- Check your blood sugar as you have been told by your doctor.
- Tell your doctor if you have signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
- Talk with your doctor before getting any vaccines. Use with this medicine may either raise the chance of an infection or make the vaccine not work as well.
- If you need to take an antacid or a drug like famotidine or ranitidine, talk with your doctor about how to take it while taking Tasigna (nilotinib).
- Avoid grapefruit and grapefruit juice.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- Use birth control that you can trust to prevent pregnancy while taking this medicine.
- If you are pregnant or you get pregnant while taking Tasigna, call your doctor right away.
How is this medicine (Tasigna) best taken?
Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take on an empty stomach. Take 1 hour before or 2 hours after meals.
- Take with a full glass of water.
- Swallow whole. Do not chew, break, or crush.
- Capsule may be opened and contents sprinkled on 1 teaspoon of applesauce. Swallow right away.
- To gain the most benefit, do not miss doses.
- Keep taking Tasigna as you have been told by your doctor or other health care provider, even if you feel well.
What do I do if I miss a dose?
- Skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of a pancreas problem (pancreatitis) like very bad stomach pain, very bad back pain, or very bad upset stomach or throwing up.
- Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
- Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up.
- Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
- Chest pain or pressure, a fast heartbeat, or passing out.
- A heartbeat that does not feel normal.
- Shortness of breath, a big weight gain, or swelling in the arms or legs.
- Change in eyesight.
- Very bad headache.
- Feeling very tired or weak.
- Leg pain, leg feels cold, or change in skin color of the leg.
What are some other side effects of Tasigna?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Upset stomach or throwing up.
- Belly pain.
- Not hungry.
- Hard stools (constipation).
- Loose stools (diarrhea).
- Muscle or joint pain.
- Back pain.
- Hair loss.
- Not able to sleep.
- Runny nose.
- Stuffy nose.
- Nose and throat irritation.
- Feeling tired or weak.
- Night sweats.
- Dry skin.
- Muscle spasm.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Tasigna?
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Check with your pharmacist about how to throw out unused drugs.
Consumer Information Use and Disclaimer
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time this medicine is refilled. If you have any questions about Tasigna, please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Tasigna. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using Tasigna.
Review Date: December 6, 2017
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