Generic Name: Nelarabine (nel AY re been)
Brand Name: Arranon
Medically reviewed on Sep 5, 2018
- This medicine may cause very bad nervous system problems. Sometimes, nervous system problems have not gone away even after treatment with nelarabine was stopped. Call your doctor right away if you feel very sleepy or confused, or are not able to move. Call your doctor right away if you have a burning, numbness, or tingling feeling that is not normal; a change in balance; problems with daily living like buttoning clothes; seizures; tripping when walking; or weakness.
Uses of Nelarabine:
- It is used to treat a type of leukemia.
- It is used to treat a type of lymphoma.
What do I need to tell my doctor BEFORE I take Nelarabine?
- If you have an allergy to nelarabine or any other part of nelarabine.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you are taking pentostatin.
- If you are breast-feeding. Do not breast-feed while you take nelarabine.
This is not a list of all drugs or health problems that interact with nelarabine.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take nelarabine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Nelarabine?
- Tell all of your health care providers that you take nelarabine. This includes your doctors, nurses, pharmacists, and dentists.
- You may feel sleepy during treatment and for several days after treatment. Avoid driving and doing other tasks or actions that call for you to be alert until you do not feel sleepy anymore.
- The ability of your bone marrow to make blood cells may be lowered. This can lead to very bad bleeding problems or infections. Tell your doctor right away if you have signs of infection like fever, chills, or sore throat; any bruising or bleeding; or if you feel very tired or weak.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- If you have upset stomach, throwing up, loose stools (diarrhea), or are not hungry, talk with your doctor. There may be ways to lower these side effects.
- If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Talk with your doctor before getting any vaccines. Use with nelarabine may either raise the chance of an infection or make the vaccine not work as well.
- If you are 65 or older, use nelarabine with care. You could have more side effects.
- If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during care and for 3 months after care ends. Use a condom.
- If you are a man and your sex partner gets pregnant while you take nelarabine or within 3 months after your last dose, call your doctor right away.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting nelarabine. Talk with your doctor.
- Use birth control that you can trust to prevent pregnancy while taking nelarabine.
- If you are pregnant or you get pregnant while taking nelarabine, call your doctor right away.
How is this medicine (Nelarabine) best taken?
Use nelarabine as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as an infusion into a vein over a period of time.
- Other drugs will be given with nelarabine to help avoid side effects.
- Drink lots of noncaffeine liquids every day unless told to drink less liquid by your doctor.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of fluid and electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, very bad dizziness or passing out, fast heartbeat, more thirst, seizures, feeling very tired or weak, not hungry, unable to pass urine or change in the amount of urine produced, dry mouth, dry eyes, or very bad upset stomach or throwing up.
- Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
- Shortness of breath.
- Pale skin.
- Any unexplained bruising or bleeding.
- Feeling very tired or weak.
- Muscle pain or weakness.
- Chest pain or pressure or a fast heartbeat.
- Swelling in the arms or legs.
- Low mood (depression).
- Very bad dizziness or passing out.
- Patients with cancer who take nelarabine may be at a greater risk of getting a bad health problem called tumor lysis syndrome (TLS). Sometimes, this has been deadly. Call your doctor right away if you have a fast heartbeat or a heartbeat that does not feel normal; any passing out; trouble passing urine; muscle weakness or cramps; upset stomach, throwing up, loose stools, or not able to eat; or feel sluggish.
What are some other side effects of Nelarabine?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling sleepy.
- Feeling tired or weak.
- Upset stomach or throwing up.
- Hard stools (constipation).
- Loose stools (diarrhea).
- Joint pain.
- Back pain.
- Stomach pain.
- Mouth irritation or mouth sores.
- Swelling of belly.
- Not hungry.
- Not able to sleep.
- Pain in arms or legs.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Nelarabine?
- If you need to store nelarabine at home, talk with your doctor, nurse, or pharmacist about how to store it.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about nelarabine, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about nelarabine
- Nelarabine Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- Drug class: antimetabolites
Other brands: Arranon