Generic Name: panobinostat (pan-oh-BIN-oh-stat)
Brand Name: Farydak
Diarrhea is common with Farydak and can be severe. If diarrhea or stomach cramps happen, you will need to take care not to become dehydrated. Call your doctor to find out what to do. Do not try to treat diarrhea without first checking with your doctor.
Severe and sometimes fatal heart problems (eg, irregular heartbeat) have happened in people taking Farydak. Irregular heartbeat may occur because of electrolyte problems. Have your blood work checked as you have been told by your doctor. You will need an electrocardiogram (ECG) before starting Farydak. You may also need to have an ECG while using Farydak. Discuss any questions or concerns with your doctor.
Farydak is used for:
Treating multiple myeloma. It may also be used for other conditions as determined by your doctor.
Farydak is a histone deacetylase inhibitor. It works by blocking the growth of some cancer cells.
Do NOT use Farydak if:
- you are allergic to any ingredient in Farydak
- you have an infection or severe liver problems
- you have a history of recent heart attack or a certain type of chest pain (unstable angina)
- you are taking amiodarone, bepridil, chloroquine, clarithromycin, disopyramide, halofantrine, methadone, moxifloxacin, pimozide, procainamide, quinidine, sotalol, or any other medicine that can cause a certain type of irregular heartbeat (prolonged QT interval). There are many medicines that can do this. Ask your doctor or pharmacist if you are not sure.
Contact your doctor or health care provider right away if any of these apply to you.
Before using Farydak:
Some medical conditions may interact with Farydak. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you are dehydrated or have nausea, vomiting, or diarrhea
- if you have blood electrolyte problems (eg, low blood magnesium or potassium levels) or blood problems (eg, anemia, low white blood cell counts, low blood platelet levels)
- if you have heart problems (eg, long QT syndrome), kidney problems, or liver problems
- if you have a history of bleeding problems, heart attack, or chest pain (angina)
Some MEDICINES MAY INTERACT with Farydak. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Amiodarone, bepridil, chloroquine, clarithromycin, disopyramide, dolasetron, halofantrine, methadone, moxifloxacin, ondansetron, pimozide, procainamide, quinidine, sotalol, or tropisetron because the risk of a certain type of irregular heartbeat (prolonged QT interval) may be increased
- Boceprevir, clarithromycin, conivaptan, indinavir, itraconazole, ketoconazole, lopinavir/ritonavir, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telaprevir, telithromycin, or voriconazole because they may increase the risk of Farydak's side effects
- Atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, pimozide, thioridazine, tolterodine, or venlafaxine because the risk of their side effects may be increased by Farydak
This may not be a complete list of all interactions that may occur. Ask your health care provider if Farydak may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Farydak:
Use Farydak as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Farydak comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Farydak refilled.
- Take Farydak by mouth with food or without food.
- Swallow Farydak whole with a cup of water. Do not open, crush, or chew before swallowing.
- If the capsule is accidentally crushed or broken, do NOT touch the powder. If you get the powder on your skin, wash the area with soap and water. If you get the powder in your eyes, flush with water.
- Avoid star fruit, pomegranate or pomegranate juice, and grapefruit or grapefruit juice while you take Farydak.
- Take Farydak at the same time of day.
- Take as you have been told, even if you feel well.
- To gain the most benefit, do not miss doses.
- If you vomit after taking a dose, skip the dose and go back to your regular dosing schedule.
- If you miss a dose of Farydak, take it as soon as possible. If it has been 12 hours or more since the missed dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Farydak.
Important safety information:
- Tell your doctor or dentist that you take Farydak before you receive any medical or dental care, emergency care, or surgery.
- Farydak may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
- Serious and sometimes fatal infections have happened with Farydak. If you have any infection, are taking antibiotics now or have taken any in the recent past, or have had many infections, talk with your doctor.
- Farydak may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
- Serious and sometimes fatal bleeding has happened with Farydak. Call your doctor right away if you have symptoms of bleeding (eg, vomiting blood or vomit that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; unusual vaginal bleeding; bruises without a reason or bruises that get bigger; any bleeding that is severe or that you cannot stop).
- If you may become pregnant, you must use an effective form of birth control while you take Farydak and for at least 1 month after you stop taking it. If you have questions about effective birth control, talk with your doctor.
- Men who take Farydak should always use a condom when having sex with a woman who may become pregnant. Do this for as long as you take Farydak and for 3 months after you stop taking it.
- Lab tests may be performed while you use Farydak. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Farydak with caution in the ELDERLY; they may be more sensitive to its effects.
- PREGNANCY and BREAST-FEEDING: Farydak may cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Farydak while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking Farydak.
Possible side effects of Farydak:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Loss of appetite; nausea; tiredness; vomiting; weakness; weight loss.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in color of skin to a bluish color (eg, on the lips, nail beds, fingers, or toes); chest pain or pressure; confusion; diarrhea; dizziness or light-headedness; fainting; fast, slow, or irregular heartbeat; one-sided weakness; pale skin; severe or persistent headache; severe or persistent nausea or vomiting; shortness of breath; slurred speech; swelling of the hands, ankles, or feet; symptoms of fluid and electrolyte problems (eg, confusion, dry mouth or eyes, fainting, fast or irregular heartbeat, loss of appetite, mood changes, more thirst, muscle pain or weakness, not able to pass urine or change in how much urine is passed, seizures, severe dizziness, unusual tiredness or weakness); symptoms of infection (eg, fever, chills, sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, painful urination, mouth sores, wound that will not heal, anal itching or pain); symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, unusual nausea or stomach pain, unusual tiredness, yellowing of the skin or eyes); unusual weakness or tiredness; vision problems.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Farydak:
Store Farydak in the original carton at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Farydak out of the reach of children and away from pets.
- If you have any questions about Farydak, please talk with your doctor, pharmacist, or other health care provider.
- Farydak is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Farydak or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Farydak. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Farydak. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Farydak.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.