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Farydak Side Effects

Generic Name: panobinostat

Note: This document contains side effect information about panobinostat. Some of the dosage forms listed on this page may not apply to the brand name Farydak.

For the Consumer

Applies to panobinostat: oral capsule

Along with its needed effects, panobinostat (the active ingredient contained in Farydak) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking panobinostat:

More common
  • Abdominal or stomach pain or tenderness
  • black, tarry stools
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • clay colored stools
  • confusion
  • cough or sore throat
  • dark or bloody urine
  • decreased appetite
  • decreased frequency or amount of urine
  • dizziness, faintness, or lightheadedness especially when getting up suddenly from a lying or sitting position
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever, chills, or sweating
  • headache
  • increased thirst
  • itching or skin rash
  • loss of appetite
  • lower back or side pain
  • muscle spasms or twitching
  • nausea or vomiting
  • nervousness
  • painful or difficult urination
  • pinpoint red spots on the skin
  • pounding in the ears
  • rapid breathing
  • seizures
  • severe diarrhea
  • slow or fast heartbeat
  • swelling of the face, fingers, feet, or lower legs
  • tingling of the hands or feet
  • trouble breathing
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • yellow eyes or skin
Less common
  • Chest pain or discomfort
  • coughing up blood
  • difficulty with swallowing
  • increased menstrual flow or vaginal bleeding
  • nosebleeds
  • pain in the shoulders, arms, jaw, or neck
  • paralysis

Some side effects of panobinostat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Acid or sour stomach
  • belching or passing gas
  • change or loss in taste
  • depressed mood
  • dry mouth
  • hair loss
  • heartburn or indigestion
  • hoarseness or husky voice
  • fatigue or feeling lethargic
  • redness of the skin

For Healthcare Professionals

Applies to panobinostat: oral capsule

Gastrointestinal

Very common (10% or more): Diarrhea (68%), nausea (36%), vomiting (26%)
Common (1% to 10%): Abdominal pain, dyspepsia, gastritis, cheilitis, abdominal distension, dry mouth, flatulence, colitis, gastrointestinal pain

Cardiovascular

Very common (10% or more): T-wave abnormalities (40%), ST-segment depression (22%), arrhythmia (12%)
Common (1% to 10%): Palpitations, hypotension, hypertension, orthostatic hypotension
Uncommon (0.1% to 1%): Cardiac ischemic events[Ref]

Hematologic

Very common (10% or more): Thrombocytopenia (97%), lymphopenia (82%), leukopenia (81%), neutropenia (75%), anemia (62%)
Common (1% to 10%): Grade 3/4 hemorrhage

Immunologic

Very common (10% or more): Severe infections (31%)
Common (1% to 10%): Hepatitis B

Hepatic

Common (1% to 10%): Increased blood alkaline phosphatase
Frequency not reported: Hepatic dysfunction (primarily aminotransferase and total bilirubin elevations)

Metabolic

Very common (10% or more): Hypocalcemia (67%), hypoalbuminemia (63%), hypophosphatemia (63%), hypokalemia (52%), hyponatremia (49%), hyperphosphatemia (29%), decreased appetite (28%), hypermagnesemia (27%), hyperbilirubinemia (21%), decreased weight (12%)
Common (1% to 10%): Hyperglycemia, dehydration, fluid retention, hypomagnesemia

Dermatologic

Common (1% to 10%): Skin lesions, rash, erythema

Endocrine

Common (1% to 10%): Hypothyroidism

Genitourinary

Common (1% to 10%): Urinary incontinence, hyperuricemia

Musculoskeletal

Common (1% to 10%): Joint swelling

Nervous system

Common (1% to 10%): Dizziness, headache, syncope, tremor, dysgeusia

Other

Very common (10% or more): Fatigue (60%), peripheral edema (29%), pyrexia (26%)
Common (1% to 10%): Chills

Psychiatric

Common (1% to 10%): Insomnia

Renal

Very common (10% or more): Increased blood creatinine (41%)
Common (1% to 10%): Renal failure, increased blood urea, decreased glomerular filtration rate

Respiratory

Common (1% to 10%): Cough, dyspnea, respiratory failure, rales, wheezing

References

1. "Product Information. Farydak (panobinostat)." Novartis Pharmaceuticals, East Hanover, NJ.

Some side effects of Farydak may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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