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Duopa

Generic Name: Carbidopa and Levodopa Enteral Suspension (kar bi DOE pa & lee voe DOE pa)
Brand Name: Duopa

Uses of Duopa:

  • It is used to treat Parkinson's disease.
  • It is used to treat signs like Parkinson's disease caused by other health problems.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Duopa?

  • If you have an allergy to levodopa, carbidopa, or any other part of Duopa (carbidopa and levodopa enteral suspension).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Glaucoma, a skin lump or growth, or a history of skin cancer.
  • If you are taking any of these drugs: Reserpine or tetrabenazine.
  • If you have taken certain drugs used for low mood (depression) like isocarboxazid, phenelzine, or tranylcypromine or drugs used for Parkinson's disease like selegiline or rasagiline in the last 14 days. Taking this medicine within 14 days of those drugs can cause very bad high blood pressure.
  • If you are taking another drug that has the same drug in it.

This is not a list of all drugs or health problems that interact with Duopa.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Duopa?

  • Tell all of your health care providers that you take Duopa. This includes your doctors, nurses, pharmacists, and dentists.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how this medicine affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
  • This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take Duopa.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • If you have high blood sugar (diabetes), talk with your doctor about which glucose tests are best to use.
  • Have your eye pressure checked. Talk with your doctor.
  • This medicine may "wear off" as the time for your next dose gets closer. Tell your doctor if this happens and it bothers you.
  • Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.
  • The chance of a type of skin cancer called melanoma may be raised in people with Parkinson's disease. It is not known if this medicine may also raise the chance. Have skin exams while you take Duopa. Talk with your doctor.
  • A dark color (red, brown, or black) may show up in your saliva, urine, or sweat. This is not harmful but may discolor your clothes.
  • If you are 65 or older, use this medicine with care. You could have more side effects.
  • Some people have fallen asleep during activities like driving, eating, or talking. Some people did not feel sleepy and felt alert right before falling asleep. This has happened up to 1 year after Duopa was started. If you fall asleep during activities, do not drive or do other tasks or actions that call for you to be alert while you take this medicine. Call your doctor right away if this happens or you feel very sleepy.
  • Neuroleptic malignant syndrome (NMS) is a very bad and sometimes deadly health problem that has happened when Duopa was stopped all of a sudden. NMS has also happened when the dose of this medicine was lowered. Call your doctor right away if you have any fever, muscle cramps or stiffness, dizziness, very bad headache, confusion, change in thinking, fast heartbeat, heartbeat that does not feel normal, or are sweating a lot.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Duopa (carbidopa and levodopa enteral suspension) while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Duopa) best taken?

Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as an infusion through a tube connected to your bowels.
  • Your doctor will teach you how to take Duopa.
  • Follow how to use as you have been told by the doctor or read the package insert.
  • Take the oral form of this medicine as you have been told by your doctor.
  • This medicine needs to be at room temperature before use. Take a cassette out of the carton and out of the refrigerator 20 minutes before using.
  • Do not reuse casettes. Do not use a cassette for longer than 16 hours, even if some drug is left.
  • If you need to disconnect the pump for a short time (less than 2 hours), follow what your doctor has told to do or read the package insert. If you need to disconnect the pump for longer than 2 hours, call your doctor to find out what to do.
  • If you take an iron product or a multivitamin that has iron, ask your doctor or pharmacist how to take it with Duopa. Iron may lower how well your body is able to absorb this medicine.
  • Diets high in protein, fat, or calories may lower how well your body absorbs Duopa; tell your doctor if you have a diet like this or if you will be changing your diet. Talk with your doctor.
  • Do not stop taking this medicine all of a sudden or lower your dose without calling your doctor. Side effects may happen. Talk with your doctor.
  • Take even during sign-free periods.
  • Keep a diary of your signs.
  • Keep taking Duopa as you have been told by your doctor or other health care provider, even if you feel well.
  • Take this medicine at the same time of day.
  • To gain the most benefit, do not miss doses.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.
  • Change in the way you act.
  • Hallucinations (seeing or hearing things that are not there).
  • Feeling confused.
  • Strong urges that are hard to control (such as eating, gambling, sex, or spending money).
  • A skin lump or growth.
  • Change in color or size of a mole.
  • Trouble controlling body movements that is new or worse.
  • Throwing up blood or throw up that looks like coffee grounds.
  • Black, tarry, or bloody stools.
  • Belly pain.
  • Chest pain or pressure or a fast heartbeat.
  • A heartbeat that does not feel normal.
  • Fever or chills.
  • Sore throat.
  • Any unexplained bruising or bleeding.
  • Very bad dizziness or passing out.
  • Very bad headache.
  • Dark urine or yellow skin or eyes.
  • Change in eyesight, eye pain, or very bad eye irritation.
  • Shortness of breath.
  • Feeling very tired or weak.
  • A burning, numbness, or tingling feeling that is not normal.
  • Problem with the device or problem where the tube goes into your body.
  • Swelling in the arms or legs.
  • Stomach or bowel problems can happen with Duopa. Some of these problems may lead to the need for surgery or may be deadly. This includes problems like stomach or bowel bleeding, blockage, or ulcers; infection or other problems where the tube goes into your body; or pancreatitis. Call your doctor right away if you have dark, tarry, or bloody stools; fever; upset stomach or throwing up; constipation that does not go away; or stomach pain.

What are some other side effects of Duopa?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Bad dreams.
  • Hard stools (constipation).
  • Dizziness.
  • Feeling sleepy.
  • Dry mouth.
  • Headache.
  • Not able to sleep.
  • Throat pain.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Duopa?

  • Store in a refrigerator. Do not freeze.
  • Store in original container.
  • Protect from light.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time this medicine is refilled. If you have any questions about Duopa, please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Duopa (carbidopa and levodopa enteral suspension). It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using Duopa.

Review Date: November 1, 2017

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