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Dapagliflozin and Saxagliptin

Generic Name: Dapagliflozin and Saxagliptin (dap a gli FLOE zin & sax a GLIP tin)
Brand Name: Qtern

Medically reviewed by Drugs.com. Last updated on Aug 3, 2019.

Uses of Dapagliflozin and Saxagliptin:

  • It is used to lower blood sugar in patients with high blood sugar (diabetes).

What do I need to tell my doctor BEFORE I take Dapagliflozin and Saxagliptin?

  • If you have an allergy to dapagliflozin and saxagliptin or any part of dapagliflozin and saxagliptin.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Acidic blood problem, bladder cancer, or type 1 diabetes.
  • If you have kidney problems.
  • If you have low blood volume.
  • If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with dapagliflozin and saxagliptin, like certain drugs that are used for HIV, infections, or depression. There are many drugs that must not be taken with dapagliflozin and saxagliptin. Your doctor or pharmacist can tell you if you are taking a drug that must not be taken with dapagliflozin and saxagliptin.
  • If you are pregnant or may be pregnant. Do not take dapagliflozin and saxagliptin if you are in the second or third trimester of pregnancy.
  • If you are breast-feeding. Do not breast-feed while you take dapagliflozin and saxagliptin.

This is not a list of all drugs or health problems that interact with dapagliflozin and saxagliptin.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take dapagliflozin and saxagliptin with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Dapagliflozin and Saxagliptin?

  • Tell all of your health care providers that you take dapagliflozin and saxagliptin. This includes your doctors, nurses, pharmacists, and dentists.
  • Low blood sugar can happen. The chance may be raised when dapagliflozin and saxagliptin is used with other drugs for diabetes. Signs may be dizziness, headache, feeling sleepy or weak, shaking, fast heartbeat, confusion, hunger, or sweating. Call your doctor right away if you have any of these signs. Follow what you have been told to do for low blood sugar. This may include taking glucose tablets, liquid glucose, or some fruit juices.
  • Do not drive if your blood sugar has been low. There is a greater chance of you having a crash.
  • To lower the chance of feeling dizzy or passing out, have your child rise slowly if your child has been sitting or lying down. Have your child be careful going up and down stairs.
  • High cholesterol has happened with dapagliflozin and saxagliptin. If you have questions, talk with the doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take dapagliflozin and saxagliptin.
  • Talk with your doctor before you drink alcohol.
  • Check your blood sugar as you have been told by your doctor.
  • Bladder cancer has happened in a few more people taking dapagliflozin and saxagliptin than in those taking other drugs for diabetes. It is not known if this drug led to these cases of bladder cancer. Talk with your doctor.
  • Kidney problems have happened. Sometimes, these may need to be treated in the hospital or with dialysis.
  • A very bad and sometimes deadly pancreas problem (pancreatitis) has happened with other drugs like this one. Talk with your doctor.
  • Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.
  • Drugs like this one may cause joint pain that can be very bad and disabling. Call your doctor right away if you have very bad joint pain or any joint pain that does not go away.
  • A rare but very bad infection has happened with drugs like this one. This infection may be deadly. Get medical help right away if your genitals or the area between your genitals and rectum becomes tender, red, or swollen, and you have a fever or do not feel well.
  • Too much acid in the blood or urine (ketoacidosis) and severe urinary tract infections (UTIs) have happened. Ketoacidosis can be deadly. Both of these may need to be treated in a hospital.
  • A skin reaction called bullous pemphigoid has happened with drugs like this one. Sometimes, people have had to go to the hospital. Call your doctor right away if you have blisters or if your skin starts to break down.
  • If you are 65 or older, use dapagliflozin and saxagliptin with care. You could have more side effects.

How is this medicine (Dapagliflozin and Saxagliptin) best taken?

Use dapagliflozin and saxagliptin as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take in the morning.
  • Take with or without food.
  • Swallow whole. Do not chew, break, or crush.
  • Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
  • To gain the most benefit, do not miss doses.
  • Keep taking dapagliflozin and saxagliptin as you have been told by your doctor or other health care provider, even if you feel well.
  • Follow the diet and workout plan that your doctor told you about.
  • It may be harder to control blood sugar during times of stress such as fever, infection, injury, or surgery. A change in physical activity, exercise, or diet may also affect blood sugar.
  • If you cannot drink liquids by mouth or if you have upset stomach, throwing up, or diarrhea that does not go away; you need to avoid getting dehydrated. Contact your doctor to find out what to do. Dehydration may lead to new or worse kidney problems.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses unless told to do so by your doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of fluid and electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, very bad dizziness or passing out, fast heartbeat, more thirst, seizures, feeling very tired or weak, not hungry, unable to pass urine or change in the amount of urine produced, dry mouth, dry eyes, or very bad upset stomach or throwing up.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Signs of too much acid in the blood (acidosis) like confusion; fast breathing; fast heartbeat; a heartbeat that does not feel normal; very bad stomach pain, upset stomach, or throwing up; feeling very sleepy; shortness of breath; or feeling very tired or weak.
  • Signs of a pancreas problem (pancreatitis) like very bad stomach pain, very bad back pain, or very bad upset stomach or throwing up.
  • Signs of a urinary tract infection (UTI) like blood in the urine, burning or pain when passing urine, feeling the need to pass urine often or right away, fever, lower stomach pain, or pelvic pain.
  • Strong odor to urine.
  • For females, vaginal yeast infection. Report itching or discharge.
  • For men, yeast infection of the penis. Report pain, swelling, rash, or discharge.
  • Heart failure has happened in people taking dapagliflozin and saxagliptin. Tell your doctor if you have ever had heart failure or kidney problems. Call your doctor right away if you feel very tired or you have shortness of breath, a big weight gain, or swelling in the arms or legs.

What are some other side effects of Dapagliflozin and Saxagliptin?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Dapagliflozin and Saxagliptin?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time dapagliflozin and saxagliptin is refilled. If you have any questions about dapagliflozin and saxagliptin, please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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