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Colchicine and Probenecid

Generic Name: Colchicine and Probenecid (KOL chi seen & proe BEN e sid)

Medically reviewed on September 5, 2018

Uses of Colchicine and Probenecid:

What do I need to tell my doctor BEFORE I take Colchicine and Probenecid?

For all patients taking colchicine and probenecid:

  • If you have an allergy to colchicine, probenecid, or any other part of colchicine and probenecid.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Blood problems or kidney stones.
  • If you have any of these health problems: Kidney disease or liver disease.
  • If you are pregnant or may be pregnant. Do not take colchicine and probenecid if you are pregnant.
  • If you are taking a salicylate drug like aspirin.
  • If you have liver or kidney problems and you take certain other drugs. Very bad and sometimes deadly side effects have happened in these people. There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.

Children:

  • If your child is younger than 2 years of age. Do not give colchicine and probenecid to a child younger than 2 years of age.

This is not a list of all drugs or health problems that interact with colchicine and probenecid.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take colchicine and probenecid with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Colchicine and Probenecid?

  • Tell all of your health care providers that you take colchicine and probenecid. This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Talk with your doctor before you drink alcohol.
  • Avoid grapefruit and grapefruit juice.
  • This medicine may have unsafe effects on the bone marrow. The bone marrow may not be able to make cells found in the blood as well as it used to for a few weeks. This may raise the chance of bleeding or infection. Talk with the doctor.
  • Deadly overdoses have happened with colchicine and probenecid in adults and children. Keep away from children. Do not take more than you were told. If this drug is taken by accident, call your poison control center or get medical care right away.
  • This medicine may affect certain lab tests. Be sure your doctor and lab workers know you use colchicine and probenecid.
  • If you are 65 or older, use colchicine and probenecid with care. You could have more side effects.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Colchicine and Probenecid) best taken?

Use colchicine and probenecid as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Follow how to take colchicine and probenecid as you have been told by your doctor. Do not use more than you were told to use.
  • Take with or without food.
  • Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
  • Follow the diet plan that your doctor told you about.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • A burning, numbness, or tingling feeling that is not normal.
  • Very upset stomach or throwing up.
  • Very loose stools (diarrhea).
  • Back pain, belly pain, or blood in the urine. May be signs of a kidney stone.
  • Not able to pass urine or change in how much urine is passed.
  • Any unexplained bruising or bleeding.
  • Feeling very tired or weak.
  • Pale skin.
  • Very bad muscle problems have happened with colchicine and probenecid. This can also lead to kidney problems. Tell your doctor if you have muscle pain or weakness, especially if you feel very tired or weak or have a fever. Tell your doctor if you are not able to pass urine or you have a change in how much urine is passed.

What are some other side effects of Colchicine and Probenecid?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Colchicine and Probenecid?

  • Store at room temperature.
  • Protect from light.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about colchicine and probenecid, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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