Generic Name: Ceritinib (se RI ti nib)
Brand Name: Zykadia
Medically reviewed on July 4, 2018
Uses of Ceritinib:
- It is used to treat lung cancer.
What do I need to tell my doctor BEFORE I take Ceritinib?
- If you have an allergy to ceritinib or any other part of ceritinib.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have a long QT on ECG.
- If you take any other drugs (prescription or OTC, natural products, vitamins). There are many drugs that interact with ceritinib, like certain drugs that are used for HIV, infections, or seizures.
- If you are taking any drugs that can cause a slow heartbeat. There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
- If you are taking St. John's wort. Do not take St. John's wort with ceritinib. This medicine may not work as well.
- If you are breast-feeding. Do not breast-feed while you take ceritinib and for 2 weeks after your last dose.
This is not a list of all drugs or health problems that interact with ceritinib.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take ceritinib with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Ceritinib?
- Tell all of your health care providers that you take ceritinib. This includes your doctors, nurses, pharmacists, and dentists.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- An unsafe heartbeat that is not normal (long QT on ECG) has happened with ceritinib. This may raise the chance of sudden death. Talk with the doctor.
- You may need to have an ECG checked before starting ceritinib and while taking it. Talk with your doctor.
- Check blood pressure and heart rate as the doctor has told you. Talk with the doctor.
- It is common to have diarrhea, upset stomach, throwing up, or stomach pain with ceritinib. Call your doctor if any of these side effects get very bad, bother you, or do not go away.
- If you have upset stomach, throwing up, loose stools (diarrhea), or are not hungry, talk with your doctor. There may be ways to lower these side effects.
- If you have high blood sugar (diabetes), talk with your doctor. This medicine may raise blood sugar.
- Check your blood sugar as you have been told by your doctor.
- Avoid grapefruit and grapefruit juice.
- This medicine may affect how much of some other drugs are in your body. If you are taking other drugs, talk with your doctor. You may need to have your blood work checked more closely while taking ceritinib with your other drugs.
- If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during care and for 3 months after care ends. Use a condom.
- If you are a man and your sex partner gets pregnant while you take ceritinib or within 3 months after your last dose, call your doctor right away.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- Use birth control that you can trust to prevent pregnancy while taking ceritinib and for 6 months after stopping ceritinib.
- If you get pregnant while taking ceritinib or within 6 months after your last dose, call your doctor right away.
How is this medicine (Ceritinib) best taken?
Use ceritinib as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take ceritinib with food.
- To gain the most benefit, do not miss doses.
- Keep taking ceritinib as you have been told by your doctor or other health care provider, even if you feel well.
- If you throw up after taking a dose, do not repeat the dose. Take your next dose at your normal time.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is less than 12 hours until the next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Any unexplained bruising or bleeding.
- Fast or slow heartbeat.
- A heartbeat that does not feel normal.
- Chest pain or pressure or passing out.
- A burning, numbness, or tingling feeling that is not normal.
- Change in balance.
- Muscle weakness.
- Change in eyesight.
- Fever or chills.
- Feeling very tired or weak.
- Very bad and sometimes deadly pancreas problems (pancreatitis) have happened with ceritinib. Call your doctor right away if you have very bad stomach pain, very bad back pain, or very upset stomach or throwing up.
- Very bad and sometimes deadly lung problems have happened with ceritinib. Call your doctor right away if you have lung or breathing problems like trouble breathing, shortness of breath, or a cough that is new or worse.
What are some other side effects of Ceritinib?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Hard stools (constipation).
- Not hungry.
- Weight loss.
- Feeling tired or weak.
- Back pain.
- Muscle pain.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Ceritinib?
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about ceritinib, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about ceritinib
- Ceritinib Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Español
- 1 Review
- Drug class: multikinase inhibitors
Other brands: Zykadia