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Generic Name: Bupropion Extended-Release Tablets (byoo PROE pee on)
Brand Name: Aplenzin, Budeprion XL, Forfivo XL, Wellbutrin XL

Medically reviewed by Last updated on Aug 29, 2020.


  • Drugs like this one have raised the chance of suicidal thoughts or actions in children and young adults. The risk may be greater in people who have had these thoughts or actions in the past. All people who take Aplenzin (bupropion extended-release tablets) need to be watched closely. Call the doctor right away if signs like low mood (depression), nervousness, restlessness, grouchiness, panic attacks, or changes in mood or actions are new or worse. Call the doctor right away if any thoughts or actions of suicide occur.

Uses of Aplenzin:

What do I need to tell my doctor BEFORE I take Aplenzin?

  • If you are allergic to Aplenzin (bupropion extended-release tablets); any part of Aplenzin (bupropion extended-release tablets); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you have ever had seizures.
  • If you drink a lot of alcohol and you stop drinking all of a sudden.
  • If you use certain other drugs like drugs for seizures or anxiety and you stop using them all of a sudden.
  • If you have ever had an eating problem like anorexia or bulimia.
  • If you have any of these health problems: Kidney disease or liver disease.
  • If you have taken certain drugs for depression or Parkinson's disease in the last 14 days. This includes isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. Very high blood pressure may happen.
  • If you are taking any of these drugs: Linezolid or methylene blue.
  • If you are taking another drug that has the same drug in it.

This is not a list of all drugs or health problems that interact with Aplenzin (bupropion extended-release tablets).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Aplenzin (bupropion extended-release tablets) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Aplenzin?

For all patients taking Aplenzin (bupropion extended-release tablets):

  • Tell all of your health care providers that you take Aplenzin (bupropion extended-release tablets). This includes your doctors, nurses, pharmacists, and dentists.
  • Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how Aplenzin (bupropion extended-release tablets) affects you.
  • This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take Aplenzin (bupropion extended-release tablets).
  • Do not stop taking Aplenzin (bupropion extended-release tablets) all of a sudden without calling your doctor. You may have a greater risk of side effects. If you need to stop Aplenzin (bupropion extended-release tablets), you will want to slowly stop it as ordered by your doctor.
  • High blood pressure has happened with Aplenzin (bupropion extended-release tablets). Have your blood pressure checked as you have been told by your doctor.
  • This medicine may raise the chance of seizures. The chance may be higher in people who have certain health problems, use certain other drugs, or drink a lot of alcohol. Talk to your doctor to see if you have a greater chance of seizures while taking Aplenzin (bupropion extended-release tablets).
  • Avoid drinking alcohol while taking Aplenzin (bupropion extended-release tablets).
  • Talk with your doctor before you use other drugs and natural products that slow your actions.
  • It may take several weeks to see the full effects.
  • This medicine is not approved for use in children. Talk with the doctor.
  • If you are 65 or older, use Aplenzin (bupropion extended-release tablets) with care. You could have more side effects.
  • Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

If you smoke:

  • Not all products are approved for use to help stop smoking. Talk with the doctor to make sure that you have the right product.
  • New or worse mental, mood, or behavior problems have happened when bupropion has been used to stop smoking. These problems include thoughts of suicide or murder, depression, forceful actions, fury, anxiety, and anger. These problems have happened in people with and without a history of mental or mood problems. Talk with the doctor.

How is this medicine (Aplenzin) best taken?

Use Aplenzin (bupropion extended-release tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Do not take Aplenzin (bupropion extended-release tablets) more often than you are told. This may raise the risk of seizures. Be sure you know how far apart to take your doses.
  • Take in the morning if taking once a day.
  • Take with or without food.
  • If you are not able to sleep, do not take Aplenzin (bupropion extended-release tablets) too close to bedtime. Talk with your doctor.
  • Swallow whole. Do not chew, break, or crush.
  • Keep taking Aplenzin (bupropion extended-release tablets) as you have been told by your doctor or other health care provider, even if you feel well.
  • If you have trouble swallowing, talk with your doctor.

What do I do if I miss a dose?

  • Skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Feeling confused, not able to focus, or change in behavior.
  • Hallucinations (seeing or hearing things that are not there).
  • If seizures are new or worse after starting Aplenzin (bupropion extended-release tablets).
  • Chest pain or pressure.
  • Fast or abnormal heartbeat.
  • Swelling.
  • Shortness of breath.
  • Change in hearing.
  • Ringing in ears.
  • Passing urine more often.
  • Swollen gland.
  • Trouble moving around.
  • Some people may have a higher chance of eye problems with Aplenzin (bupropion extended-release tablets). Your doctor may want you to have an eye exam to see if you have a higher chance of these eye problems. Call your doctor right away if you have eye pain, change in eyesight, or swelling or redness in or around the eye.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

What are some other side effects of Aplenzin?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Dizziness or headache.
  • Constipation, diarrhea, stomach pain, upset stomach, throwing up, or feeling less hungry.
  • Shakiness.
  • Feeling nervous and excitable.
  • Strange or odd dreams.
  • Gas.
  • Dry mouth.
  • Trouble sleeping.
  • Muscle or joint pain.
  • Nose or throat irritation.
  • Sweating a lot.
  • A change in weight without trying.
  • For some brands, you may see the tablet shell in your stool. For these brands, this is normal and not a cause for concern. If you have questions, talk with your doctor.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Aplenzin?

  • Store at room temperature protected from light. Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Aplenzin (bupropion extended-release tablets) is refilled. If you have any questions about Aplenzin (bupropion extended-release tablets), please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.