Ticarcillin Side Effects

It is possible that some side effects of ticarcillin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to ticarcillin: injectable powder for injection

Get emergency medical help if you have any of these signs of an allergic reaction while taking ticarcillin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • diarrhea that is watery or bloody;

  • easy bruising or bleeding, unusual weakness;

  • dry mouth, increased thirst, confusion, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting;

  • fever, chills, body aches, flu symptoms; or

  • skin rash, bruising, severe tingling, numbness, pain, muscle weakness.

Less serious side effects may be more likely to occur, such as:

  • mild diarrhea, gas, stomach pain;

  • nausea or vomiting;

  • headache;

  • skin rash or itching;

  • pain, swelling, or burning where the injection was given; or

  • vaginal yeast infection (itching or discharge).

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

For Healthcare Professionals

Applies to ticarcillin: injectable powder for injection

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, diarrhea, and pseudomembranous colitis.[Ref]

Local

Local side effects have included injection site pain and induration. Vein irritation and phlebitis may occur when undiluted ticarcillin is injected directly.[Ref]

Hypersensitivity

Hypersensitivity reactions have included skin rashes, pruritus, urticaria, drug fever, and anaphylaxis.[Ref]

Metabolic

Some studies show a positive correlation between the degree of hypokalemia, the dose of ticarcillin, and the serum BUN/creatinine ratio, suggesting dehydration and higher doses are risk factors for the development of ticarcillin-associated hypokalemia.[Ref]

Metabolic abnormalities have included hypernatremia and hypokalemia.[Ref]

Hematologic

Hematologic side effects have included anemia, thrombocytopenia, leukopenia, neutropenia, and eosinophilia.[Ref]

Hepatic

Hepatic side effects have included elevations of SGOT and SGPT.[Ref]

Nervous system

Nervous system side effects may include convulsion or neuromuscular excitability with high doses.[Ref]

References

1. Croydon EA, Hermoso C "An evaluation of the safety and tolerance to timentin." J Antimicrob Chemother 17 (1986): 233-40

2. Sanders CV, Marier RL, Aldridge KE, Derks FW, Martin DH "Safety and effectiveness of ticarcillin plus clavulanic acid in the treatment of community-acquired acute pyelonephritis in adult women." Am J Med 79 (1985): 96-100

3. "Product Information. Ticar (ticarcillin)." SmithKline Beecham, Philadelphia, PA.

4. Link AS, Jr "Efficacy and safety of ticarcillin plus clavulanic acid and piperacillin in patients with lower respiratory tract infections." Am J Med 79 (1985): 86-7

5. Shenep JL, Hughes WT, Roberson PK, et al "Vancomycin, ticarcillin, and amikacin compared with ticarcillin-clavulanate and amikacin in the empirical treatment of febrile, neutropenic children with cancer." N Engl J Med 319 (1988): 1053-8

6. Brown LA, Goldberg ND, Shearer WT "Long-term ticarcillin desensitization by the continuous oral administration of penicillin." J Allergy Clin Immunol 69 (1982): 51-4

7. Ramirez-Ronda CH, Gutierrez J, Bermudez RH "Comparative effectiveness, safety and tolerance of mezlocillin and ticarcillin: a prospective randomized trial." J Antimicrob Chemother 9 (1982): 125-9

8. Mostow SR, O'Brien RF "Safety and effectiveness of ticarcillin plus clavulanate potassium in treatment of lower respiratory tract infections." Am J Med 79 (1985): 78-80

9. Nanji AA, Lindsay J "Ticarcillin associated hypokalemia." Clin Biochem 15 (1982): 118-9

10. Finch RA "Hypernatremia during lithium and ticarcillin therapy." South Med J 74 (1981): 376-7

11. Welter J, Wittman DH, Freitag V "Ticarcillin therapy of risk patients with infections due to pseudomonas aeruginosa." J Int Med Res 9 (1981): 44-51

12. Stuart JJ "Ticarcillin-induced hemorrhage in a patient with thrombocytosis." South Med J 73 (1980): 1084-5

13. Fass RJ, Copelan EA, Brandt JT, Moeschberger ML, Ashton JJ "Platelet-mediated bleeding caused by broad-spectrum penicillins." J Infect Dis 155 (1987): 1242-8

14. Singh N, Yu VL, Mieles LA, Wagener MM "Beta-lactam antibiotic-induced leukopenia in severe hepatic dysfunction: risk factors and implications for dosing in patients with liver disease." Am J Med 94 (1993): 251-6

15. Gastineau D, Spector R, Philips D "Severe neutropenia associated with ticarcillin therapy." Ann Intern Med 94 (1981): 711-2

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