Amoxicillin and Clavulanate

Pronunciation

Generic Name: amoxicillin and clavulanate potassium (am OX ih sil in KLAV yoo la nayt po TASS ee um)
Brand Names: Augmentin, Augmentin ES-600, Augmentin XR

What is the most important information I should know about Amoxicillin and clavulanate?

If you have ever had an allergic reaction to penicillin or to a cephalosporin, you may also be allergic to Amoxicillin and clavulanate. Tell your doctor about any past drug allergies.

If you switch from one tablet form to another (regular, chewable, or extended-release tablet), take only the new tablet form and strength prescribed for you. The strength of clavulanate potassium is not the same among the different tablet forms, even though the amount of amoxicillin may be the same as in the tablet you were using before. This medicine may not be as effective or could be harmful if you do not use the exact tablet form your doctor has prescribed.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Amoxicillin and clavulanate will not treat a viral infection such as the common cold or flu. Amoxicillin and clavulanate can pass into breast milk and may cause a yeast infection, diarrhea, or allergic reaction in a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Amoxicillin and clavulanate can make birth control pills less effective. Use a second non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking Amoxicillin and clavulanate.

What is Amoxicillin and clavulanate?

Amoxicillin and clavulanate is an antibiotic in a group of drugs called penicillins. Amoxicillin and clavulanate fights bacteria in the body.

Amoxicillin and clavulanate is used to treat many different infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin.

Slideshow: The Shocking Truth About Antibiotic Resistance

Amoxicillin and clavulanate may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking Amoxicillin and clavulanate?

If you have ever had an allergic reaction to penicillin or to a cephalosporin, you may also be allergic to Amoxicillin and clavulanate. Tell your doctor about any past drug allergies.

Before taking Amoxicillin and clavulanate, tell your doctor if you have:

  • liver disease (or a history of hepatitis or jaundice);
  • kidney disease; or
  • mononucleosis.

If you have any of these conditions, you may not be able to use Amoxicillin and clavulanate, or you may need a dosage adjustment or special tests during treatment.

Some forms of this medication contain as much as 7 mg of phenylalanine per dose. Tell your doctor if you have phenylketonuria (PKU) or otherwise need to restrict your intake of phenylalanine.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Amoxicillin and clavulanate can pass into breast milk and may cause a yeast infection, diarrhea, or allergic reaction in a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Amoxicillin and clavulanate?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger or smaller amounts, or take it for longer than recommended by your doctor.

If you switch from one tablet form to another (regular, chewable, or extended-release tablet), take only the new tablet form and strength prescribed for you. The strength of clavulanate potassium is not the same among the different tablet forms, even though the amount of amoxicillin may be the same as in the tablet you were using before. This medicine may not be as effective or could be harmful if you do not use the exact tablet form your doctor has prescribed. Take each dose with a full glass of water. Take the medicine at the start of a meal to reduce stomach upset.

The Augmentin tablet should be swallowed whole.

The Augmentin Chewable tablet must be chewed before swallowing. Do not swallow a chewable tablet whole.

Do not crush or chew the Augmentin XR (extended-release) tablet. Swallow the pill whole, or break the pill in half and take both halves one at a time. If you have trouble swallowing a whole or half pill, talk with your doctor about using another form of Amoxicillin and clavulanate. Shake the liquid form of this medicine well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Amoxicillin and clavulanate should be taken at evenly spaced intervals as prescribed. It is important to take Amoxicillin and clavulanate regularly to get the most benefit.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Amoxicillin and clavulanate will not treat a viral infection such as the common cold or flu.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using Amoxicillin and clavulanate.

Store the tablets at room temperature away from moisture and heat. Store the liquid form of this medicine in the refrigerator. Throw away any unused liquid after 10 days.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of an Amoxicillin and clavulanate overdose may include nausea, vomiting, stomach pain, skin rash, drowsiness, or hyperactivity.

What should I avoid?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

What are the possible side effects of Amoxicillin and clavulanate?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have diarrhea that is severe or lasts longer than 3 days, or if you have nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

Keep taking the medication and talk with your doctor if you have any of these less serious side effects:

  • mild diarrhea, gas, stomach pain;

  • nausea or vomiting;

  • headache;

  • skin rash or itching;

  • white patches in your mouth or throat; or

  • vaginal yeast infection (itching or discharge).

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

See also: Side effects (in more detail)

What other drugs will affect Amoxicillin and clavulanate?

Before taking Amoxicillin and clavulanate, tell your doctor if you are using any of the following drugs:

  • allopurinol (Zyloprim);

  • probenecid (Benemid); or

  • another antibiotic (for the same or for a different infection).

If you are using any of these drugs, you may not be able to use Amoxicillin and clavulanate, or you may need dosage adjustments or special tests during treatment.

Amoxicillin and clavulanate can make birth control pills less effective. Use a second non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking Amoxicillin and clavulanate.

There may be other drugs not listed that can affect Amoxicillin and clavulanate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist has additional information about Amoxicillin and clavulanate written for health professionals that you may read.

What does my medication look like?

Amoxicillin and clavulanate is available with a prescription under the brand name Augmentin. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Augmentin chewable 125 mg- round, yellow, lemon-limeflavored tablets

  • Augmentin chewable 200 mg - round, pink, cherry-bananaflavored tablets

  • Augmentin chewable 250 mg - round, mottled-yellow, lemon-limeflavored tablets

  • Augmentin chewable 400 mg - round, mottled-pink, cherry-bananaflavored tablets

  • Augmentin 250 mg - oval, white, film-coated tablets

  • Augmentin 500 mg - oval, white, film-coated tablets

  • Augmentin 875 mg - capsule-shaped, white, scored tablets

  • Augmentin suspension 125 mg per 5 mL (1 teaspoon)banana-flavored liquid

  • Augmentin suspension 200 mg per 5 mL (1 teaspoon) orange-raspberryflavored liquid

  • Augmentin suspension 250 mg per 5 mL (1 tsp)orange-flavored liquid

  • Augmentin suspension 400 mg per 5 mL (1 teaspoon) orange-raspberryflavored liquid

  • Augmentin ES-600 suspension 600 mg per 5 mL (1 teaspoon)orange-raspberry-flavored suspension

  • Augmentin XR 1000mg - oval, white, film-coated tablets

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2014 Cerner Multum, Inc. Version: 6.02. Revision Date: 2/6/07 11:02:14 AM.
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