Ticarcillin Dosage

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Usual Adult Dose for Febrile Neutropenia

3 g IV every 4 hours. Therapy should be continued for approximately 14 days, or until more specific therapy may be substituted for a proven infection, or until the patient has been afebrile for 24 hours after the absolute neutrophil count has been greater than 500 cells/mm3.

Ticarcillin should be used in combination with another anti-infective agent, usually an aminoglycoside, for the empiric treatment of febrile patients.

Usual Adult Dose for Intraabdominal Infection

3 g IV every 4 hours, for 7 to 14 days depending on the nature and severity of the infection.

Usual Adult Dose for Joint Infection

3 g IV every 4 hours for up to 3 or 4 weeks, depending on the nature and severity of the infection. Longer therapy, sometimes up to 6 weeks, may be necessary for prosthetic joint infections.

Usual Adult Dose for Osteomyelitis

3 g IV every 4 hours. Therapy should be continued for 4 to 6 weeks. Chronic osteomyelitis may require additional oral antimicrobial therapy, possibly up to 6 months.

Usual Adult Dose for Pelvic Inflammatory Disease

3 g IV every 4 to 6 hours. Parenteral therapy should continue for 48 hours after clinical improvement is observed, at which time oral therapy may be initiated and continued for a total of 14 days of treatment.

If the patient is not pregnant, appropriate treatment for possible chlamydia infection should be initiated and any sexual partner(s) should be evaluated.

The Centers for Disease Control and Prevention currently recommend cefotetan or cefoxitin plus doxycycline, or clindamycin plus gentamicin for the treatment of pelvic inflammatory disease.

Usual Adult Dose for Peritonitis

3 g IV every 4 hours. Ticarcillin is generally used as part of combination therapy when treating peritonitis. Therapy should be continued for approximately 10 to 14 days.

Intraperitoneal cefazolin plus ceftazidime are recommended for treatment of peritoneal dialysis-associated peritonitis.

Usual Adult Dose for Pneumonia

3 g IV every 4 hours for 21 to 28 days, depending on the nature and severity of the infection.

Usual Adult Dose for Pyelonephritis

3 g IV every 4 to 6 hours for 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Septicemia

3 g IV every 4 hours for 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Skin or Soft Tissue Infection

3 g IV every 4 hours for 7 to 10 days, or for 3 days after acute inflammation resolves, depending on the nature and severity of the infection.

Usual Adult Dose for Urinary Tract Infection

Complicated: 3 g IV every 4 to 6 hours for 14 days, depending on the nature and severity of the infection.
Uncomplicated: 1 g IM or IV every 6 hours

Usual Pediatric Dose for Intraabdominal Infection

Neonates:
< 7 days, birthweight < 2000 g: 75 mg/kg IV every 12 hours
< 7 days, birthweight > 2000 g: 75 mg/kg IV every 8 hours

> 7 days, birthweight < 1200 g: 75 mg/kg every 12 hours
> 7 days, birthweight < 2000 g: 75 mg/kg IV every 8 hours
> 7 days, birthweight > 2000 g: 75 mg/kg every 6 hours or 100 mg/kg IV every 8 hours

1 month to 12 years:
< 40 kg: 100 to 300 mg/kg/day IV in equally divided doses every 4 to 6 hours
> 40 kg: Adult dose

Usual Pediatric Dose for Pneumonia

Neonates:
< 7 days, birthweight < 2000 g: 75 mg/kg IV every 12 hours
< 7 days, birthweight > 2000 g: 75 mg/kg IV every 8 hours

> 7 days, birthweight < 1200 g: 75 mg/kg every 12 hours
> 7 days, birthweight < 2000 g: 75 mg/kg IV every 8 hours
> 7 days, birthweight > 2000 g: 75 mg/kg every 6 hours or 100 mg/kg IV every 8 hours

1 month to 12 years:
< 40 kg: 100 to 300 mg/kg/day IV in equally divided doses every 4 to 6 hours
> 40 kg: Adult dose

Usual Pediatric Dose for Skin or Soft Tissue Infection

Neonates:
< 7 days, birthweight < 2000 g: 75 mg/kg IV every 12 hours
< 7 days, birthweight > 2000 g: 75 mg/kg IV every 8 hours

> 7 days, birthweight < 1200 g: 75 mg/kg every 12 hours
> 7 days, birthweight < 2000 g: 75 mg/kg IV every 8 hours
> 7 days, birthweight > 2000 g: 75 mg/kg every 6 hours or 100 mg/kg IV every 8 hours

1 month to 12 years:
< 40 kg: 100 to 300 mg/kg/day IV in equally divided doses every 4 to 6 hours
> 40 kg: Adult dose

Usual Pediatric Dose for Septicemia

Neonates:
< 7 days, birthweight < 2000 g: 75 mg/kg IV every 12 hours
< 7 days, birthweight > 2000 g: 75 mg/kg IV every 8 hours

> 7 days, birthweight < 1200 g: 75 mg/kg every 12 hours
> 7 days, birthweight < 2000 g: 75 mg/kg IV every 8 hours
> 7 days, birthweight > 2000 g: 75 mg/kg every 6 hours or 100 mg/kg IV every 8 hours

1 month to 12 years:
< 40 kg: 200 to 300 mg/kg/day IV in equally divided doses every 4 to 6 hours
> 40 kg: Adult dose

Usual Pediatric Dose for Urinary Tract Infection

Uncomplicated infections:
1 month to 12 years:
< 40 kg: 50 to 100 mg/kg/day IV or IM in equally divided doses every 6 to 8 hours.
> 40 kg: Adult dose.

Complicated infections:
1 month to 12 years:
< 40 kg: 150 to 200 mg/kg/day IV in equally divided doses every 4 to 6 hours.
> 40 kg: Adult dose.

Renal Dose Adjustments

Adults:
CrCl < 10 mL/min: Initial loading dose of 3 g followed by 2 g IV every 12 hours or 1 g IM every 6 hours.

CrCl 10 to 30 mL/min: Initial loading dose of 3 g followed by 2 g IV every 8 hours.

CrCl 30 to 60 mL/min: Initial loading dose of 3 g followed by 2 g IV every 4 hours.

Liver Dose Adjustments

Adults:
Hepatic dysfunction and CrCl < 10 mL/min: 3 g IV once as a loading dose, followed by 2 g IV every 24 hours.

Dose Adjustments

Doses as high as 400 mg/kg/day IV equally divided every 4 to 6 hours have been used to treat acute pulmonary exacerbations of cystic fibrosis.

Dialysis

Adults:
Hemodialysis: 3 g IV once as a loading dose, followed by 2 g IV every 12 hours supplemented with 3 g after each dialysis.

Peritoneal dialysis: 3 g IV every 12 hours

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