Nafarelin

Generic Name: nafarelin (NAF-a-REL-in)
Brand Name: Synarel

Nafarelin is used for:

Treating endometriosis, including relieving pain and reducing lesions. It is also used to treat early puberty (central precocious puberty [CPP]) in children of both sexes. It may also be used for other conditions as determined by your doctor.

Nafarelin is a gonadotropin-releasing hormone (GnRH) agonist. It works by decreasing production of certain steroids in the body, which decreases the symptoms of endometriosis or early puberty.

Do NOT use nafarelin if:

  • you are allergic to any ingredient in nafarelin, GnRH, or another GnRH agonist (eg, histrelin)
  • you are pregnant, may become pregnant, or are breast-feeding
  • you have undiagnosed abnormal vaginal bleeding

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: Does Your Child Have ADHD? Recognizing Signs & Treatment Options

Before using nafarelin:

Some medical conditions may interact with nafarelin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • you are planning to become pregnant
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a runny or stuffy nose, osteoporosis (weak bones), or a family history of osteoporosis
  • if you regularly use alcohol or tobacco
  • if the patient is a child with endometriosis
  • if you are taking medicines that can weaken the bones, such as anticonvulsants (eg, phenytoin) or corticosteroids (eg, prednisone)

Some MEDICINES MAY INTERACT with nafarelin. However, no specific interactions with nafarelin are known at this time.

Ask your health care provider if nafarelin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use nafarelin:

Use nafarelin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with nafarelin. Talk to your pharmacist if you have questions about this information.
  • The pump must be primed before the first use. To prime the pump, hold it upright, pointed away from yourself and others. Pump 7 to 10 times, until you see a fine spray. Do this only before the first use of a new bottle. Do not do this before each dose.
  • Gently blow your nose before using nafarelin.
  • This nasal spray is used differently in children than in adults. Be sure you know how to use nafarelin. Ask your doctor or pharmacist if you have any questions about how to use it.
  • When you insert the spray tip into the nose, be sure to point it toward the back and outer side of the nose.
  • If you are using more than 1 spray in the same nostril, wait at least 30 seconds between sprays.
  • Clean the spray tip before and after each use. To do this, rinse the tip of the spray unit in warm water for 15 seconds while wiping the tip with a finger or a soft cloth. Dry with a clean tissue or soft cloth. Do NOT try to clean it with a pointed object or take apart the pump.
  • If you are also using a decongestant nasal spray, do not use it within 2 hours after using nafarelin. Check with your doctor if you have questions about using nafarelin along with your other medicines.
  • It may take 4 to 8 weeks for nafarelin to work. Continue to use nafarelin even if you feel well. Do not miss any doses.
  • If you miss a dose of nafarelin, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
  • If you miss more than 1 dose of nafarelin, contact your doctor.

Ask your health care provider any questions you may have about how to use nafarelin.

Important safety information:

  • Avoid sneezing during or immediately after using nafarelin, if possible, because nafarelin's effectiveness may be decreased.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • If you are using nafarelin for CPP, you may experience some signs of puberty (eg, vaginal bleeding, breast enlargement, increased pubic hair) or temporary body odor during the first month of treatment. This is normal. If these side effects persist or are severe, contact your doctor.
  • If you are using nafarelin for endometriosis, you may experience irregular or unusual vaginal bleeding during the first 2 months you use nafarelin. This is normal. If you experience severe or persistent vaginal bleeding or if you have unusual vaginal bleeding that lasts longer than 2 months after you start nafarelin, contact your doctor.
  • Your menstrual period should stop while you use nafarelin. Contact your doctor if your regular menstrual period continues while you are using nafarelin.
  • Women who may become pregnant must have a negative pregnancy test before beginning treatment with nafarelin.
  • Women of childbearing age should avoid becoming pregnant while using nafarelin. To prevent pregnancy, use a nonhormonal form of birth control (eg, condoms) while using nafarelin. Do not use birth control pills while you use nafarelin.
  • Women who miss more than 1 dose of nafarelin in a row may experience breakthrough vaginal bleeding and ovulation, with the possibility of pregnancy. Contact your doctor if you miss more than 1 dose of nafarelin.
  • Nafarelin may cause your bones to weaken or become more prone to fractures, especially if you use nafarelin for long periods of time. Contact your doctor if you experience bone pain or if you have concerns regarding changes in bone density. Discuss any questions or concerns with your doctor.
  • Tell your doctor or dentist that you take nafarelin before you receive any medical or dental care, emergency care, or surgery.
  • Rarely, a serious pituitary gland problem (pituitary apoplexy) has been reported with the use of GnRH agonists. This serious problem usually occurs shortly after beginning treatment. Contact your doctor immediately if you experience a sudden headache, vomiting, fainting, eye weakness, inability to move your eyes, mental status changes, or vision changes.
  • Nafarelin may interfere with certain lab tests, including diagnostic tests of pituitary gonadotropic and gonadal function. Be sure your doctor and lab personnel know you are using nafarelin.
  • Lab tests, including gonadal sex steroid levels, bone density, and growth rate, may be performed while you use nafarelin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Nafarelin should be used with extreme caution in CHILDREN younger than 18 years old who have endometriosis; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use nafarelin if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if nafarelin is found in breast milk. Do not breast-feed while taking nafarelin.

Possible side effects of nafarelin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Acne; dandruff; decreased sexual desire; headache; hot flashes; mood swings; muscle pain; nasal irritation; runny nose; temporary increase or decrease in breast size; trouble sleeping; vaginal dryness; weight change.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; continued menstrual periods; depression; irregular heartbeat; mental or mood changes; seizures; severe, persistent, or unusual vaginal bleeding; shortness of breath; stomach pain; sudden headache or vomiting; swelling of the hands or feet; vision changes; whitish or brownish vaginal discharge; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of nafarelin:

Store nafarelin upright at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Do not freeze. Store away from heat, moisture, and light. Keep nafarelin out of the reach of children and away from pets.

General information:

  • If you have any questions about nafarelin, please talk with your doctor, pharmacist, or other health care provider.
  • Nafarelin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take nafarelin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about nafarelin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to nafarelin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using nafarelin.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

Hide
(web2)
Close