Lupron Depot User Reviews & Ratings

• TZAK
• January 3, 2012

For Uterine Fibroids "I just received my 2nd shot of 3.75 Lupron and so far so good! I have heard horror stories not only on line, but from my friends who have been on it for various reasons and I was more than worried to start it. I have one large fibroid and I was put on Lupron injections to shrink it to make it easier for my husband and I to have a baby after I have a robotic myomectomy in June. I was so afraid of mood swings, but surprisingly, after 5 weeks I am still very happy. My bloating has gone away for the most part and I am really looking forward to not bleeding the way I did due to this fibroid! All in all, I am posting on here so that woman like myself, a 35 year old wanting a baby will know that not all Lupron horror stories will happen to you!"

• fibro...
• Taken for 1 to 6 months
• January 22, 2015

For Uterine Fibroids "Awesome stuff! I went on Lupron so I could be a candidate for focused ultrasound treatment. Don't let all the negative reviews scare you! I used to look about 4 months pregnant. I am otherwise healthy, thin and exercise regularly. Had minor hot flashes; not a big deal considering the overall benefits. My mass of fibroids shrank dramatically in 3 months. Previously hard, round abdominal area shrank considerably! I couldn't believe how successful Lupron was for me, and how good I felt on it. I went off the pill (which I was on for years for constant bleeding/spotting). Didn't have memory loss, hair loss or bad moods like many other women's experiences. I took vitamins while on it to help counteract things like possible bone loss."

• Anonymous
• August 6, 2010

For Uterine Fibroids "I can't say enough about how glad I am that I was given Lupron injections! I was being treated for heavy non-stop bleeding caused by the several large fibroids I had. I was told by 3 different Doctor's that I would definitely need to have a hysterectomy. I really had no other option. My OBGYN and the surgeon, started me on the Lupron injections 4 months ago to stop the bleeding (I had become extremely anemic and couldn't have the surgery until my blood counts came back up which would take 3 months) and to try and shrink the fibroids. After my 4th and final shot 2 weeks ago, my MRI showed that the fibroids had shrunk 75% and my surgeon discharged me today saying that I will NOT be having a hysterectomy, nor any surgery! Thank you Lupron."

• Joya
• Taken for 1 to 6 months
• February 7, 2019

For Uterine Fibroids "I believe having this injection and educating yourself on the side effects goes hand in hand. I knew it could cause depletion of bones, I doubled up on calcium. I knew it would throw me into menopause, I immediately and consistently took black cohash. I had a hemoglobin of 6.5. It stopped my heavy periods which allowed it to rise to 12 in order to not have to have a transfusion during or after my hysterectomy. Educate yourself and prepare your body for the injection. The injection can not do all of the work, nor should you expect to."

• mrm
• August 2, 2016

For Uterine Fibroids "I had a fibroid that had grown into my uterine cavity and it caused heavy bleeding, large blood clots, and discomfort. I had surgery scheduled in June of 2016 and was given a Lupron injection in March of 2016 to shrink the fibroid to make surgery easier. I had read terrible reviews and was scared of the side effects. Overall my experience was very positive, I had minor side effects such as hot flashes and migraines. I am in my mid-twenties and very active, which I believe helped. No weight gain or hair loss. I felt great throughout the 3 months and actually felt more mentally and hormonally balanced then ever before...I'm actually kind of upset it has worn off! Don't be afraid of this drug, it worked wonders for me!"

• Sarah
• January 2, 2016

For Endometriosis "Don't let the online reviews cheat you out of a better life! I actually delayed getting Lupron by a year because I was so scared by the online reviews and reports of adverse reactions/symptoms. However, my experience was wonderful. My doctor put me on the ad-back and I did have a FEW hot flashes initially, but I would take those 1,000x over the pain my endometriosis caused me. I also took calcium to offset any bone density loss. Please, Please, Please work with your doctor to decide if Lupron is right for YOU. I did it and now I am on my way to restoring my quality of life."

• geezer
• Taken for 1 to 2 years
• March 6, 2021

For Prostate Cancer "I completely agree with Rob, if i had have known the consequences of taking this drug, I would probably done the same as him. It takes away everything that being a man is. He does not however mention the sex word, from my first injection 5 years ago there has not been any, plenty of everything else that he states but no kind of love making. Probably he did not take enough to cause e/d, if not good on him. Not enough information is given to us about the FULL effects of this drug, men are not made to live a good QOL without testosterone, because after you have been castrated that is it. As far as I can tell very few men have good sex and real happiness after having the drug."

• stres...
• August 18, 2018

For Prostate Cancer "My husband was diagnosed with prostate cancer stage 4 in 2014. His prostate was removed and later started on Lupron depot every 3 months. His PSA went down to almost nil. Over the next four years he has been on Lupron according to his PSA levels. Though Lupron does keep his PSA levels down, his mood swings/anger and his irrational thinking has stressed our relationship. He is mean with comments to me and his actions. He needs Lupron to live but it has killed our relationship. The Oncologist who gave him his first Lupron injection, did tell us, that one of the side effects of Lupron was that it could increase moods and anger. I am stressing to you, wives, that Lupron is one ugly drug. It makes people who are receiving Lupron depots very miserable people and their partners/spouses very stressed out, scared at times, lonely and sad for what is happening in their relationship. Lupron gives the patient, quantity of life but not quality of life!"

• Dr C
• June 20, 2013

For Uterine Fibroids "I took this medication for 6 months due to extreme monthly bleeding caused by fibroids. I didn't have a period or spotting the entire 6 months or for 3 months after my last injection. I did not have even 1 side effect. It was a great experience. Hopefully I will have the same success with the Depo Shot!"

• Lupron...
• Taken for 1 to 6 months
• February 19, 2019

For Uterine Fibroids "I wanted to write a review for other women who are thinking about getting this injection. I read a lot of horror stories online so I was pretty nervous. I got the 3 month injection to try and shrink my large fibroids. Upshot is, it wasn't that bad but my fibroids didn't shrink; however, it stopped my periods. Preventing the excessive bleeding is good for health prior to hysterectomy. But it's expensive and insurance will make you jump through bureaucratic hoops to get it. After getting the shot, I felt kind of weird. Then I had one last awful period blowout a few days later. Since then, no periods. Menopause symptoms included hot flashes, brain fog, mild acne, some moodiness and irritability. However I think a lot of this can be worked around with good nutrition, exercise, breathable clothing, meditation."

• Krizia
• May 15, 2015

For Uterine Fibroids "I've been on Lupron since March 2015. Just had my 2nd shot. I have to tell you it's taken 100% of my nagging back pain and cramps away. I even lost 12 pounds the first shot. It started to wear out towards the end so I took the shot 2 weeks early. I had surgery May 12th to remove a huge polyp and 2 fibroid tumors - all benign. I'm having hot flashes and some headaches, some joint pain and that's about it. These symptoms are worth the trade from previous symptoms. I only hope my doctor gives me a hysterectomy soon. She feels Lupron will shrink the fibroids outside my uterus. I'm almost 50 so she says I should hold off on the hysterectomy. I want all this done with. Good luck to all of you."

• Oace
• February 3, 2014

For Prostate Cancer "Started treatment 12/2011 ended 12/2013. The PSA went down as expected for is the purpose of treatment, now waiting for side effects to end, which have been: loss of libido, hot flashes specially at night or after a meal, some sweating, loss of body hair, loss of muscle mass, joint and bone pain, tiredness, difficulty to start almost any quest, weight gain, chest/man breast augmentation. Have been taking vitamin D plus calcium, glucosamine, started an exercise program that has helped with muscle buildup, and also helps with better mood, by prescription have taken 3 applications of calcium to the vein. Have had excellent support from wife, have trust my Doctors and first of all God my father."

• 65...
• Taken for 6 months to 1 year
• November 22, 2015

For Prostate Cancer "I am experiencing the following side-effects: Breast enlargement, reduction of size of testicles, complete ED, multiple hot flashes hourly, and a mental fog that prevents clear thinking. These were all expected side effects and came as no surprise. Additional unexpected side effects include: rapid pulse rate, elevated BP, breathlessness, short term memory loss, extreme and uncontrollable emotional outbursts (uncontrollable crying over minimally emotional issues), and sleep deprivation (1-2 hours total sleep which could account for the emotional issues). Of additional concern are anecdotal statements by others claiming no reduction of any side effects even after years of removal from follow-up injections of Lupron. My concern is great enough to request suspension of this drug, even at the cost of an elevated PSA with a corresponding resurgence of the cancer. I know there are additional drugs I can take to counteract some of these side-effects, but I would rather not complicate the situation with even more medication. My PSA stands at .3 as of this writing, and I would withdraw my request were it to increase to 4.0, however continued living with this nightmare drug is not my idea of life."

• Ber...
• Taken for less than 1 month
• May 7, 2014

For Uterine Fibroids "I must admit, after reading the commens I was real scared, but I told my self everyone's body reacts differently. May, 6/2014 I took my first shot so far I am feeling great. I was a bit drained before I took the shot, woke up feeling energetic."

• mike
• September 17, 2009

For Prostate Cancer "I've been on Lupron (after prostae surgery) for a period of 7-1/2 years. I am also on 50mg Casosex. The side effects are minor (hot sweats, decreased energy) Injection site(s) were moved after 6 yrs. from buttox to shoulder(s) due to lower back pain. I hope this gives hope to patients about to begin this regimen."

• Jensey
• Taken for 1 to 6 months
• February 13, 2020

For Endometriosis "I feel like I’m one of the few people who has had a POSITIVE experience on the medicine Lupron . I’ve been pain-free from my endometriosis for 3 months, now on my third dose. After my first dose, I had some joint pain and severe hot flashes for a couple weeks, but those symptoms lessened as time went on. My mood has changed for the better while on this medicine, I no longer have pain from the endometriosis, and my only symptom from this medicine are minor hot flashes!! I can’t believe it. This medicine has been a blessing."

• Lindz
• Taken for less than 1 month
• September 30, 2018

For Endometriosis "I’m a 24-year-old female who’s suffered from terrible endometriosis pain; my periods left me crumpled up on the ground, moaning in pain, to the point that I seriously wished I were dead. I am not exaggerating in the slightest. Sometimes I’d get really dizzy and hear an intense buzzing in my ears, right before I almost passed out. The pain was unbearable; I often had to miss school and work because of my period. I recently underwent surgery and was recommended Lupron. I read horrible reviews about it for weeks leading up to my doctor appointment and was terrified to try it, but so far I haven’t had any problems other than hot flashes (and that’s MUCH preferable to the agonizing pain I used to be in). Of course, it’s only been a few months since I got the injection, so we’ll see...but so far it’s been great! Don’t let the reviews scare you; if you’re in good health like I am, you probably won’t experience serious complications or side effects. Hope this helps!"

• lupron...
• Taken for 1 to 6 months
• August 25, 2018

For Prostate Cancer "I had prostrate cancer 10 yrs ago so they say. 43 treatments of radiation and the PSA is gone. Now 67 years old and my PSA went up to 8.5 10 years later and my doctor wants to do the lupron shot. First one 2 years a big one 45 mg. It almost killed me - I had never been so sick. Now 2 and half years later my PSA was 13 so I told the doc I would try a smaller dose so I did 7.5 a year ago and another 7.5 last week my PSA is 3.2 but still said I should take it. Let me tell you men I WILL NEVER TAKE ANOTHER LUPRON SHOT AS LONG AS I LIVE. The side effects you read about are true, blood pressure problems diabetes. I'm never having lupron shot ever again."

• Working...
• Taken for 1 to 6 months
• March 19, 2018

For Uterine Fibroids "I am 52 (5'8", 155 lbs) w/ large (13 cm) intramural fibroid (fibroid w/in the muscle wall of the uterus). In case I had any adverse reaction to Lupron, decided to take the low dose injection (1 x a month) instead of the single high dose that lasts three months. Felt pretty okay w/ Lupron, other than a dull headache that lingered on for two months (I only had two injections). The actual fibroid did not shrink much after two months (from 13 to 11 cm) but the surgeon said it made the fibroid softer. Had a laparoscopic hysterectomy w/ success. 90% recovered after five days."

• K Sta...
• Taken for 1 to 6 months
• September 27, 2019

For Prostate Cancer "I was given this poison, for the first time , May 2nd, 2019. The Doctors/nurses would NOT tell me the name of it. Only referred to it as: Hormone Therapy. 60 seconds AFTER the nurse shoved a 22.5mg 3-month dose of it, into my butt....the 'Doctor's assistant, walked up to me , handed me a booklet: 'Understanding Lupron Therapy", said: You better TAKE THIS HOME AND READ IT", she 'laughed, turned around and said: "see ya". When I got home, I turned to the 1st page. It said: "side-effects': "heart attacks, strokes, bone damage, diabetes, AND, "SUDDEN DEATH......" I was so angry. She injected me with a POISON. For 10 weeks, I was l was so angry, mad it was indescribable bad. The "worst 3 months of my life" !"

• WWII...
• Taken for less than 1 month
• August 7, 2014

For Prostate Cancer "Had my first injection of Lupron 7.5 mg in July; second injection at the same dosage is set for August 21. So far no hot flashes or side effects. Have been taking Casodex simultaneously (30-day supply) which will end shortly. Only side effect from that initially was fatigue, which resolved after 5 days. Decided to insist on 1-month Lupron injections instead of a 3-6 month extended dose as PC support group participants on the once-a-month dose had far fewer side effects. I'm sticking to my guns on this one; MD tried to give me a 6-month dose right off the bat. I'm switching MDs and glad I did it this way. Hope this helps others."

• Ambear
• November 2, 2015

For Endometriosis "I have been taking this for 6 months now, about to start my 7th and I love it! I will say the first month or so, I was really wondering what had I gotten myself into. But now, I am so glad I did it. I take the 1 a month not the 3 months shot. I haven't had a period in 5 months, I haven't cramped in 5 months. I was having hot flashes before I started taking this and I will say that at times they are way worse but I would much rather deal with hot flashes then be huddled over in my bed bc the cramps are so bad that I can't even function. I do understand that some people have bad experiences with things and some people don't It is all up to your body. Everyone's body is different. I hope seeing a good review like this will help."

• I...
• August 19, 2016

For Uterine Fibroids "I have been on lupron for 3 years. I began the shot in 2013 with a 11 cm fibroid too large for surgery at time. I am now in my late 50's and still testing positive on hormon tests. another words if I go off lupron I a assuming the fibroid will grow again and I will begin again to menstruated and have heavy bleed and large clots. my headaches became much less and only have hotflashes towards the end of my 3 month shot. I get shots quarterly. my bone density was just shy from normal with no concerns for many years. I take calcium, D3 and K2 (MK7-helps make calcium go to bone not soft tissue like calcification and bone spurs ). for me is has been the best thing in my life. I can't imagine why people have bad results. oh and no weight gain."

• Anonymous
• Taken for 1 to 6 months
• August 26, 2019

For Uterine Fibroids "I got my first Lupron shot on 07/22/2019 for fibroids. My obgyn decided to put me on Lupron to attempt to shrink my fibroids/Uterus so I can have a safe hysterectomy. I haven't had a menstrual cycle since 07/22/2019 that's awesome. So far I am experiencing: first week my buttock was very sore/tender from the injection site. I am experiencing a lot hot flashes through out the day and at night they last a few minutes. No night sweats. My body, but mainly my legs ache and feel tingly/numb. Restless nights, having trouble staying asleep. My hair is now very dry and brittle and hair loss. (It was healthy before). Vaginal dryness. Memory problems, trouble focusing. I am forgetting a lot of things. Major mood swings, from very angry to crying. Increased appetite (carb craving). I hope all this is worth it at the end. None of these side effects are unbearable but I definitely do not feel myself. Round 2 coming up 10/22/2019."

• amaya
• Taken for 1 to 6 months
• November 19, 2012

For Endometriosis "I started Lupron about a month ago. I started taking it after the doctor told me I had stage 1 endometriosis. About a year before I found out I had PCOS which caused me to gain a lot of weight, about 23lbs. Since I've been on Lupron I've been feeling so much better and I've LOST 7LBS!! The only thing I have been struggling with is the hot flashes. other than that I've been doing very well on the shot."