Casodex

Generic Name: bicalutamide (bye ka LOO ta mide)
Brand Names: Casodex

What is Casodex?

Casodex is an anti-androgen. It works in the body by preventing the actions of androgens (male hormones).

Casodex is used together with another hormone to treat prostate cancer.

Casodex may also be used for purposes other than those listed in this medication guide.

Important information about Casodex

Before taking Casodex, tell your doctor if you have liver disease or if you use a blood thinner such as warfarin (Coumadin). Casodex is given as part of a combination prostate cancer treatment with another medication that prevents the testicles from producing testosterone. You should not start taking this medication until you have received the other medication prescribed as part of your treatment.

Your doctor may occasionally change your Casodex dose to make sure you get the best results from this medication. Do not stop taking Casodex without your doctor's advice. If you stop your treatment suddenly, your condition may become worse.

To be sure Casodex is helping your condition and is not causing harmful effects, your prostate and liver function will need to be checked with blood tests on a regular basis. Do not miss any scheduled appointments.

Call your doctor at once if you have a serious side effect such as chest pain, shortness of breath, swelling, blood in your urine, or stomach pain with loss of appetite, dark urine, and yellowing of your skin or eyes.

Casodex should never be taken by a woman or a child. Although Casodex is not for use by women, this medication can cause birth defects if a woman is exposed to it during pregnancy.

What should I discuss with my healthcare provider before taking Casodex?

You should not use Casodex if you are allergic to bicalutamide, or if you have liver disease.

Before taking Casodex, tell your doctor if you have liver disease or any other serious illness. You may not be able to take Casodex, or you may need a dose adjustment or special tests during treatment.

Casodex should never be taken by a woman or a child. Although Casodex is not for use by women, this medication can cause birth defects if a woman is exposed to it during pregnancy.

How should I take Casodex?

Take Casodex exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Casodex is given as part of a combination prostate cancer treatment with another medication called a luteinizing (LOO-tee-in-ize-ing) hormone-releasing hormone, or LHRH. This medication prevents the testicles from producing testosterone.

Casodex is usually taken once per day in the morning or evening. You may take the medicine with or without food. Try to take the medication at the same time each day.

LHRH is given as an injection or a tiny implant injected through a needle under the skin around your navel. LHRH injections are given at intervals such as once every 4 weeks longer. Follow your doctor's instructions.

You should not start taking Casodex until you have received the LHRH injection prescribed as part of your treatment.

Your doctor may occasionally change your Casodex dose to make sure you get the best results from this medication. Do not stop taking this medication without your doctor's advice. If you stop your treatment suddenly, your condition may become worse.

To be sure this medication is helping your condition and is not causing harmful effects, your prostate and liver function will need to be checked with blood tests on a regular basis. Do not miss any scheduled appointments.

Store this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

Call your doctor for instructions if you miss an appointment for your LHRH injection.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

An overdose of Casodex is not expected to produce life-threatening symptoms.

What should I avoid while taking Casodex?

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using Casodex.

Casodex side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

• chest pain;

• cough or trouble breathing;

• feeling short of breath, even with mild exertion;

• swelling in your hands or feet;

• blood in your urine; or

• nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

• hot flashes;

• breast pain or swelling;

• weakness;

• back pain, pelvic pain, joint or muscle pain;

• increased nighttime urination;

• stomach pain, nausea, vomiting, loss of appetite;

• diarrhea or constipation;

• weight changes;

• impotence, loss of interest in sex, or trouble having an orgasm;

• dizziness, headache; or

• sore throat, runny nose or other cold symptoms.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect Casodex?

Before taking Casodex, tell your doctor if you are taking a blood thinner such as warfarin (Coumadin).

There may be other medicines that can interact with Casodex. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about Casodex.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with other, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2008 Cerner Multum, Inc. Version: 1.07. Revision Date: 01/07/2008 10:41:18 AM.

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